Nuclear DNA from two early Neandertals reveals 80,000 years of genetic continuity in Europe.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
07
01
2019
accepted:
22
05
2019
entrez:
29
6
2019
pubmed:
30
6
2019
medline:
1
5
2020
Statut:
epublish
Résumé
Little is known about the population history of Neandertals over the hundreds of thousands of years of their existence. We retrieved nuclear genomic sequences from two Neandertals, one from Hohlenstein-Stadel Cave in Germany and the other from Scladina Cave in Belgium, who lived around 120,000 years ago. Despite the deeply divergent mitochondrial lineage present in the former individual, both Neandertals are genetically closer to later Neandertals from Europe than to a roughly contemporaneous individual from Siberia. That the Hohlenstein-Stadel and Scladina individuals lived around the time of their most recent common ancestor with later Neandertals suggests that all later Neandertals trace at least part of their ancestry back to these early European Neandertals.
Identifiants
pubmed: 31249872
doi: 10.1126/sciadv.aaw5873
pii: aaw5873
pmc: PMC6594762
doi:
Substances chimiques
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaaw5873Subventions
Organisme : European Research Council
ID : 694707
Pays : International
Références
Nat Rev Genet. 2012 Oct;13(10):745-53
pubmed: 22965354
Am J Phys Anthropol. 1995 Mar;96(3):215-34
pubmed: 7785722
BMC Biol. 2018 Oct 25;16(1):121
pubmed: 30359256
PLoS Comput Biol. 2014 Apr 10;10(4):e1003537
pubmed: 24722319
Science. 2017 Nov 3;358(6363):655-658
pubmed: 28982794
Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14616-21
pubmed: 17715061
Nature. 2011 Jul 13;475(7357):493-6
pubmed: 21753753
Z Morphol Anthropol. 1977 Jul;68(2):129-49
pubmed: 930235
Cell. 2018 Mar 22;173(1):53-61.e9
pubmed: 29551270
Curr Biol. 2008 Nov 11;18(21):1687-93
pubmed: 18976917
J Dent Res. 1991 Jul;70(7):1057-60
pubmed: 2066487
Nat Commun. 2017 Jul 04;8:16046
pubmed: 28675384
Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15758-63
pubmed: 24019490
Genome Res. 2014 Sep;24(9):1543-9
pubmed: 25081630
Theor Popul Biol. 2012 Mar;81(2):179-95
pubmed: 22155588
Nature. 2014 Jan 16;505(7483):403-6
pubmed: 24305051
Sci Rep. 2016 Mar 29;6:23559
pubmed: 27020421
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20220-5
pubmed: 18077342
Adv Dent Res. 2001 Aug;15:42-5
pubmed: 12640738
Nucleic Acids Res. 1995 Nov 25;23(22):4742-3
pubmed: 8524672
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
Genome Res. 2011 Oct;21(10):1705-19
pubmed: 21803858
Science. 2014 Jun 20;344(6190):1358-63
pubmed: 24948730
Science. 2008 Jun 27;320(5884):1787-9
pubmed: 18511654
Am J Phys Anthropol. 1987 Jun;73(2):227-31
pubmed: 3113264
Bioinformatics. 2010 Mar 1;26(5):589-95
pubmed: 20080505
Science. 2017 May 12;356(6338):605-608
pubmed: 28450384
Nature. 2016 Mar 24;531(7595):504-7
pubmed: 26976447
Nucleic Acids Res. 2017 Jun 2;45(10):e79
pubmed: 28119419
Science. 2012 Oct 12;338(6104):222-6
pubmed: 22936568
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5836-40
pubmed: 9576971
Nature. 2012 Mar 07;483(7388):169-75
pubmed: 22398555
Genetics. 1989 Aug;122(4):957-66
pubmed: 2759432
Cell. 2008 Aug 8;134(3):416-26
pubmed: 18692465
Biotechniques. 2012 Feb;52(2):87-94
pubmed: 22313406
Curr Biol. 2013 Apr 8;23(7):553-559
pubmed: 23523248
Nature. 2014 Jan 2;505(7481):43-9
pubmed: 24352235
Cold Spring Harb Protoc. 2010 Jun;2010(6):pdb.prot5448
pubmed: 20516186
PLoS One. 2012;7(8):e43949
pubmed: 22937134
Proc Natl Acad Sci U S A. 2014 May 6;111(18):6666-71
pubmed: 24753607
Nature. 2005 Sep 1;437(7055):69-87
pubmed: 16136131
Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15696-700
pubmed: 26630009
J Dent Res. 1978 Feb;57(2):270
pubmed: 277521
PLoS One. 2012;7(3):e34131
pubmed: 22479540
Nucleic Acids Res. 2012 Jan;40(1):e3
pubmed: 22021376
PLoS One. 2010 Nov 16;5(11):e14004
pubmed: 21103372
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2229-34
pubmed: 24469802
Sci Rep. 2015 Jun 17;5:11184
pubmed: 26081994
Evolution. 1983 Jan;37(1):203-217
pubmed: 28568026
Nature. 2014 Oct 23;514(7523):445-9
pubmed: 25341783
Curr Biol. 2006 Jun 6;16(11):R400-2
pubmed: 16753548
Nat Protoc. 2013 Apr;8(4):737-48
pubmed: 23493070
Nature. 2011 Jan 27;469(7331):529-33
pubmed: 21270892
Am J Phys Anthropol. 2007 Apr;132(4):489-500
pubmed: 17243124
Theor Popul Biol. 1984 Oct;26(2):119-64
pubmed: 6505980
Bioinformatics. 2015 May 15;31(10):1680-2
pubmed: 25596205
Nature. 2010 Dec 23;468(7327):1053-60
pubmed: 21179161
Bioinformatics. 2011 Nov 1;27(21):2987-93
pubmed: 21903627
Am J Phys Anthropol. 1978 Jan;50(1):115-8
pubmed: 736108
Mol Biol Evol. 2013 Dec;30(12):2725-9
pubmed: 24132122
Scand J Dent Res. 1973;81(4):335-8
pubmed: 4518605
Curr Biol. 2010 Feb 9;20(3):231-6
pubmed: 20045327
Arch Oral Biol. 2007 Sep;52(9):822-7
pubmed: 17368559
Nature. 2008 Nov 6;456(7218):53-9
pubmed: 18987734
BMC Genomics. 2012 May 10;13:178
pubmed: 22574660
Nucleic Acids Res. 2014 Oct;42(18):e141
pubmed: 25100869
Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2223-7
pubmed: 23341637
Nature. 2018 Sep;561(7721):113-116
pubmed: 30135579
Cold Spring Harb Perspect Biol. 2013 Jul 01;5(7):
pubmed: 23729639
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Nature. 2014 Aug 21;512(7514):306-9
pubmed: 25143113
Science. 2010 May 7;328(5979):710-722
pubmed: 20448178
Nature. 2018 Mar 29;555(7698):652-656
pubmed: 29562232
Bioinformatics. 2002 Feb;18(2):337-8
pubmed: 11847089
Nature. 2012 Jun 28;486(7404):527-31
pubmed: 22722832
Genome Biol. 2013 May 29;14(5):R51
pubmed: 23718773
Nature. 2010 Apr 8;464(7290):894-7
pubmed: 20336068
Genome Res. 2017 Jul;27(7):1230-1237
pubmed: 28408382
Mol Ecol Resour. 2011 Sep;11(5):759-69
pubmed: 21592312
Mol Biol Evol. 2011 Apr;28(4):1505-17
pubmed: 21177316
Nucleic Acids Res. 2016 Jan 4;44(D1):D717-25
pubmed: 26590259
J Mol Evol. 1996 Feb;42(2):145-52
pubmed: 8919866
Mol Biol Evol. 1993 May;10(3):512-26
pubmed: 8336541
J Hum Evol. 2013 Mar;64(3):169-93
pubmed: 23266488
Biotechniques. 2015 Aug 01;59(2):87-93
pubmed: 26260087
Am J Phys Anthropol. 2005 Oct;128(2):312-7
pubmed: 15861426
Genome Res. 2011 Jun;21(6):936-9
pubmed: 20980556
Science. 2009 Jul 17;325(5938):318-21
pubmed: 19608918
Sci Adv. 2017 Jul 07;3(7):e1700186
pubmed: 28695206
Nat Genet. 1999 Oct;23(2):147
pubmed: 10508508
Theor Popul Biol. 2002 Mar;61(2):225-47
pubmed: 11969392
Bioinformatics. 2014 May 1;30(9):1310-1
pubmed: 24451621
Sci Rep. 2016 Jul 06;6:29005
pubmed: 27381450
Nature. 2016 Feb 25;530(7591):429-33
pubmed: 26886800