Interference of Monoclonal Gammopathy with Fibrinogen Assay Producing Spurious Dysfibrinogenemia.
coagulation factors
fibrin
fibrinogen
inhibitor
Journal
TH open : companion journal to thrombosis and haemostasis
ISSN: 2512-9465
Titre abrégé: TH Open
Pays: Germany
ID NLM: 101715740
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
04
12
2018
accepted:
08
02
2019
entrez:
29
6
2019
pubmed:
30
6
2019
medline:
30
6
2019
Statut:
epublish
Résumé
Abnormal coagulation properties indicative of a dysfibrinogenemia were found in the plasma of an asymptomatic 65-year-old male. An immunoglobulin k light chain was found to interfere with Fg functional assay and coagulation tests (activated partial thromboplastin time, prothrombin time, and thrombin time). Steroid therapy reduced the inhibitory effect (after dexamethasone treatment coagulation test and functional Fg value normalized). Spurious dysfibrinogenemia associated with light chain monoclonal gammopathy of undetermined significance was diagnosed.
Identifiants
pubmed: 31249984
doi: 10.1055/s-0039-1683969
pii: 180066
pmc: PMC6524915
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e64-e66Références
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