Association of Symptoms of Obstructive Lung Disease and All-Cause Mortality in Older Adult Smokers.
Aged
Case-Control Studies
Comorbidity
Cough
/ epidemiology
Dyspnea
/ epidemiology
Ex-Smokers
/ statistics & numerical data
Female
Humans
Longitudinal Studies
Male
Prospective Studies
Pulmonary Disease, Chronic Obstructive
/ classification
Severity of Illness Index
Smokers
/ statistics & numerical data
Smoking
/ epidemiology
FEV1
aging
obstructive lung disease
smoking
survival
Journal
Journal of the American Geriatrics Society
ISSN: 1532-5415
Titre abrégé: J Am Geriatr Soc
Pays: United States
ID NLM: 7503062
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
20
02
2019
revised:
17
05
2019
accepted:
28
05
2019
pubmed:
30
6
2019
medline:
26
5
2020
entrez:
29
6
2019
Statut:
ppublish
Résumé
This study aims to investigate the impact of respiratory symptoms in current and former smokers with and without obstructive lung disease (OLD) on all-cause mortality. Secondary analysis in a prospective cohort (the Health, Aging and Body Composition study). Memphis, Tennessee, and Pittsburgh, Pennsylvania. Black and white men and women with a history of current and former smoking (N = 596; 63% male and 37% female) aged 70-79 years followed for 13 years. Participants were categorized into 4 mutually exclusive groups based on symptom profile and forced expiratory volume in the 1st second to forced vital capacity ratio. The groups were Less Dyspnea-No OLD (N = 196), More Dyspnea-No OLD (N = 104), Less Dyspnea-With OLD (N = 162), and More Dyspnea-With OLD (N = 134). All-cause mortality. Overall, 53% in Less Dyspnea-No OLD, 63% in More Dyspnea-No OLD, 67% in Less Dyspnea-With OLD, and 84% in More Dyspnea-With OLD died within the 13- year follow up period (log-rank χ OLD is associated with high risk of death with different risk profiles based on symptom group. Patients with symptoms of shortness of breath without OLD should be considered an at-risk group given their similar mortality to those with OLD with minimal symptoms. J Am Geriatr Soc 67:2116-2122, 2019.
Identifiants
pubmed: 31250432
doi: 10.1111/jgs.16052
pmc: PMC6800777
mid: NIHMS1042473
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2116-2122Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR066262
Pays : United States
Organisme : NIA NIH HHS
ID : N01 AG062101
Pays : United States
Organisme : NIA NIH HHS
ID : R01-AG051624
Pays : United States
Organisme : NIA NIH HHS
ID : N01-AG-6-2103
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR012459
Pays : United States
Organisme : NIA NIH HHS
ID : N01 AG062103
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG028050
Pays : United States
Organisme : NIA NIH HHS
ID : N01-AG-6-2106
Pays : United States
Organisme : NIA NIH HHS
ID : N01-AG-6-2101
Pays : United States
Organisme : NIA NIH HHS
ID : R01-AG028050
Pays : United States
Organisme : Wake Forest CTSI Program
ID : UL1TR001420
Pays : International
Organisme : NINR NIH HHS
ID : R01-NR012459
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG051624
Pays : United States
Organisme : NIA NIH HHS
ID : N01 AG062106
Pays : United States
Informations de copyright
© 2019 The American Geriatrics Society.
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