Enhanced Inhibition of Influenza A Virus Adhesion by Di- and Trivalent Hemagglutinin Inhibitors.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
11 07 2019
11 07 2019
Historique:
pubmed:
30
6
2019
medline:
23
6
2020
entrez:
29
6
2019
Statut:
ppublish
Résumé
Multivalent carbohydrate-based ligands were synthesized and evaluated as inhibitors of the adhesion protein HA of the influenza A virus (IAV). HA relies on multivalency for strong viral adhesion. While viral adhesion inhibition by large polymeric molecules has proven viable, limited success was reached for smaller multivalent compounds. By linking of sialylated LAcNAc units to di- and trivalent scaffolds, inhibitors were obtained with an up to 428-fold enhanced inhibition in various assays.
Identifiants
pubmed: 31251606
doi: 10.1021/acs.jmedchem.9b00303
pmc: PMC6627469
doi:
Substances chimiques
Antiviral Agents
0
Glycoconjugates
0
Hemagglutinin Glycoproteins, Influenza Virus
0
Ligands
0
Sialic Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6398-6404Références
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