Mechanism of Inactivation of Ornithine Aminotransferase by (1
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
10 07 2019
10 07 2019
Historique:
pubmed:
30
6
2019
medline:
23
9
2020
entrez:
29
6
2019
Statut:
ppublish
Résumé
The inhibition of ornithine aminotransferase (OAT), a pyridoxal 5'-phosphate-dependent enzyme, has been implicated as a treatment for hepatocellular carcinoma (HCC), the most common form of liver cancer, for which there is no effective treatment. From a previous evaluation of our aminotransferase inhibitors, (1
Identifiants
pubmed: 31251613
doi: 10.1021/jacs.9b03254
pmc: PMC6754100
mid: NIHMS1048343
doi:
Substances chimiques
Carboxylic Acids
0
Cyclopentanes
0
Enzyme Inhibitors
0
Ornithine-Oxo-Acid Transaminase
EC 2.6.1.13
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
10711-10721Subventions
Organisme : NIDA NIH HHS
ID : P30 DA018310
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA030604
Pays : United States
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