Stabilization of microtubules by cevipabulin.

Animals Hydrocarbons, Halogenated / chemistry Microscopy, Fluorescence Microtubules / metabolism Molecular Docking Simulation Molecular Structure Nanotechnology Paclitaxel / chemistry Protein Stability / drug effects Swine Time-Lapse Imaging / methods Triazoles / chemistry Tubulin / metabolism
Cevipabulin Kinesin Microtubule Motility assay Persistence length

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
27 08 2019
Historique:
received: 12 06 2019
accepted: 17 06 2019
pubmed: 30 6 2019
medline: 7 7 2020
entrez: 30 6 2019
Statut: ppublish

Résumé

We report the utility of cevipabulin as a stabilizing agent for microtubules. Cevipabulin-stabilized microtubules were more flexible compared to the microtubules stabilized by paclitaxel, the most commonly used microtubule stabilizing agent. Similar to the paclitaxel-stabilized microtubules, cevipabulin-stabilized microtubules were driven by kinesins in an in vitro gliding assay. The velocity of cevipabulin-stabilized microtubules was significantly higher than that of paclitaxel-stabilized microtubules. These findings will enrich the variety of microtubules with difference in mechanical and dynamic properties and widen their applications in nanotechnology.

Identifiants

DOI: 10.1016/j.bbrc.2019.06.095 PMID: 31253401
pubmed: 31253401
pii: S0006-291X(19)31231-8
doi: 10.1016/j.bbrc.2019.06.095
pii:
doi:

Substances chimiques

Hydrocarbons, Halogenated 0
Triazoles 0
Tubulin 0
cevipabulin P14M0DWS2J
Paclitaxel P88XT4IS4D

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

760-764

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Syeda Rubaiya Nasrin (SR)

Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, 060-0810, Hokkaido, Japan.

Arif Md Rashedul Kabir (AM)

Faculty of Science, Hokkaido University, Sapporo, 060-0810, Hokkaido, Japan.

Akihiko Konagaya (A)

Department of Computational Intelligence and Systems Science, Tokyo Institute of Technology, Yokohama, 226-8502, Japan.

Tsukasa Ishihara (T)

Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, 305-8566, Japan.

Kazuki Sada (K)

Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, 060-0810, Hokkaido, Japan; Faculty of Science, Hokkaido University, Sapporo, 060-0810, Hokkaido, Japan.

Akira Kakugo (A)

Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, 060-0810, Hokkaido, Japan; Faculty of Science, Hokkaido University, Sapporo, 060-0810, Hokkaido, Japan. Electronic address: kakugo@sci.hokudai.ac.jp.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Stabilization of microtubules by cevipabulin.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Stabilization of microtubules by cevipabulin.
questionsmedicales.fr › Techniques d'investigation › Microscopie de fluorescence › Stabilization of microtubules by cevipabulin.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Microtubules › Stabilization of microtubules by cevipabulin.
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Stabilization of microtubules by cevipabulin.
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Stabilization of microtubules by cevipabulin.
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Miniaturisation › Nanotechnologie › Stabilization of microtubules by cevipabulin.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Taxoïdes › Paclitaxel › Stabilization of microtubules by cevipabulin.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Stabilité protéique › Stabilization of microtubules by cevipabulin.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Stabilization of microtubules by cevipabulin.
questionsmedicales.fr › Sciences de l'information › Processus de copie › Enregistrement sur magnétoscope › Imagerie accélérée › Stabilization of microtubules by cevipabulin.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Stabilization of microtubules by cevipabulin.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Tubuline › Stabilization of microtubules by cevipabulin.