ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.

APOBEC-3G Deaminase / metabolism CD4-Positive T-Lymphocytes / virology Cells, Cultured Cullin Proteins / metabolism HIV Infections / pathology Host-Pathogen Interactions Humans Immune Evasion Models, Theoretical Proteolysis Proteome / analysis Ubiquitin-Protein Ligases / metabolism Virus Replication vif Gene Products, Human Immunodeficiency Virus / metabolism
AP-MS APOBEC3 ARIH2 CUL5 HIV Vif host-virus interactions

Journal

Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316

Informations de publication

Date de publication:
10 07 2019
Historique:
received: 15 05 2018
revised: 24 12 2018
accepted: 26 04 2019
pubmed: 30 6 2019
medline: 22 11 2019
entrez: 30 6 2019
Statut: ppublish

Résumé

The Cullin-RING E3 ligase (CRL) family is commonly hijacked by pathogens to redirect the host ubiquitin proteasome machinery to specific targets. During HIV infection, CRL5 is hijacked by HIV Vif to target viral restriction factors of the APOBEC3 family for ubiquitination and degradation. Here, using a quantitative proteomics approach, we identify the E3 ligase ARIH2 as a regulator of CRL5-mediated APOBEC3 degradation. The CUL5

Identifiants

DOI: 10.1016/j.chom.2019.05.008 PMID: 31253590 PMC: PMC7153695
pubmed: 31253590
pii: S1931-3128(19)30253-7
doi: 10.1016/j.chom.2019.05.008
pmc: PMC7153695
mid: NIHMS1533232
pii:
doi:

Substances chimiques

CUL5 protein, human 0
Cullin Proteins 0
Proteome 0
vif Gene Products, Human Immunodeficiency Virus 0
vif protein, Human immunodeficiency virus 1 0
ARIH2 protein, human EC 2.3.2.27
Ubiquitin-Protein Ligases EC 2.3.2.27
APOBEC-3G Deaminase EC 3.5.4.5

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

86-99.e7

Subventions

Organisme : NHLBI NIH HHS
ID : P01 HL089707
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI120694
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135990
Pays : United States
Organisme : NIAID NIH HHS
ID : K22 AI136691
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA177322
Pays : United States
Organisme : NIGMS NIH HHS
ID : R37 GM069530
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG011085
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM082250
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI106754
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI063302
Pays : United States
Organisme : NIDA NIH HHS
ID : DP2 DA042423
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM078360
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI118610
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI027763
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Références

Nat Med. 2003 Nov;9(11):1404-7
pubmed: 14528300
Cell Host Microbe. 2014 Dec 10;16(6):795-805
pubmed: 25464832
J Biol Chem. 2015 Apr 17;290(16):10504-17
pubmed: 25724652
Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4653-8
pubmed: 9114046
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6576-E6584
pubmed: 28739890
Cell Cycle. 2016 Aug 2;15(15):1986-96
pubmed: 27254819
J Mol Biol. 2013 Apr 12;425(7):1172-82
pubmed: 23318957
Methods Enzymol. 2014;546:1-20
pubmed: 25398333
Cell. 2018 Dec 13;175(7):1931-1945.e18
pubmed: 30550790
Cell. 2013 Mar 28;153(1):206-15
pubmed: 23453757
Mol Cell. 2003 Sep;12(3):591-601
pubmed: 14527406
Cell Host Microbe. 2015 Jul 8;18(1):109-21
pubmed: 26118995
EMBO J. 2018 Sep 14;37(18):
pubmed: 30166453
Nucleic Acids Res. 2014 Dec 16;42(22):e168
pubmed: 25300484
Cell. 2011 Nov 23;147(5):1024-39
pubmed: 22118460
PLoS Pathog. 2012;8(7):e1002772
pubmed: 22807672
Nat Methods. 2013 Aug;10(8):715-21
pubmed: 23900254
Nat Biotechnol. 2014 Mar;32(3):223-6
pubmed: 24727771
Biomolecules. 2014 Oct 13;4(4):897-930
pubmed: 25314029
Nature. 2011 Dec 21;481(7381):365-70
pubmed: 22190034
Science. 2014 Jan 3;343(6166):84-87
pubmed: 24336571
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Mol Cell. 2009 Feb 27;33(4):483-95
pubmed: 19250909
Curr Gene Ther. 2005 Aug;5(4):387-98
pubmed: 16101513
Nat Commun. 2013;4:1642
pubmed: 23535663
Curr Opin Microbiol. 2015 Oct;27:62-8
pubmed: 26275922
Bioinformatics. 2014 Sep 1;30(17):2524-6
pubmed: 24794931
Nat Rev Microbiol. 2007 Apr;5(4):253-63
pubmed: 17325726
Cell. 2009 Jul 23;138(2):389-403
pubmed: 19615732
Cell Rep. 2016 Oct 25;17(5):1438-1452
pubmed: 27783955
Science. 2015 Nov 27;350(6264):1096-101
pubmed: 26472758
PLoS Pathog. 2018 Jan 5;14(1):e1006830
pubmed: 29304101
J Biol Chem. 2012 Aug 24;287(35):29679-89
pubmed: 22767593
J Virol. 2010 Sep;84(18):9613-7
pubmed: 20592068
Cell Rep. 2012 Sep 27;2(3):616-27
pubmed: 22959436
Nat Microbiol. 2016 Jul;1(7):16068
pubmed: 27375898
Nature. 2003 Mar 20;422(6929):330-4
pubmed: 12646924
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
Mol Cell. 2018 Aug 16;71(4):637-648.e5
pubmed: 30118682
J Proteome Res. 2014 Sep 5;13(9):4205-10
pubmed: 25102069
EMBO J. 2013 Oct 30;32(21):2848-60
pubmed: 24076655
Cell. 2016 Aug 25;166(5):1198-1214.e24
pubmed: 27565346
Nature. 2011 Dec 21;481(7381):371-5
pubmed: 22190037
Life Sci. 2018 Aug 15;207:350-354
pubmed: 29913185
Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10437-42
pubmed: 26216948
Mol Cell. 2015 Jan 22;57(2):329-340
pubmed: 25616068
Cell. 2014 Jun 19;157(7):1671-84
pubmed: 24949976
Cell Rep. 2015 May 26;11(8):1236-50
pubmed: 25981045
Cell. 2017 Nov 30;171(6):1326-1339.e14
pubmed: 29103612
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Structure. 2013 Jun 4;21(6):1030-41
pubmed: 23707686
Curr Protoc Bioinformatics. 2012 Sep;Chapter 8:Unit8.15
pubmed: 22948729
Nat Protoc. 2019 Jan;14(1):1-27
pubmed: 30559373
J Virol. 2003 Oct;77(19):10548-56
pubmed: 12970439
Annu Rev Biochem. 2009;78:399-434
pubmed: 19489725
Genes Dev. 2004 Dec 1;18(23):2861-6
pubmed: 15574592
Nat Commun. 2013;4:1641
pubmed: 23535662
Nat Methods. 2014 Aug;11(8):783-784
pubmed: 25075903
Mol Cell. 2010 Mar 26;37(6):784-96
pubmed: 20347421
J Biol Chem. 2007 Feb 16;282(7):4728-37
pubmed: 17148442
Nucleic Acids Res. 2009 Jan;37(1):1-13
pubmed: 19033363
Mol Cell. 2015 Jan 22;57(2):349-60
pubmed: 25544563
Mol Cell. 2013 Feb 21;49(4):632-44
pubmed: 23333304
Bioinformatics. 2010 Apr 1;26(7):966-8
pubmed: 20147306
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D659-63
pubmed: 16381953
Mol Cell Proteomics. 2012 Dec;11(12):1541-50
pubmed: 22962057
Cell Host Microbe. 2013 Sep 11;14(3):232-41
pubmed: 24034610
J Virol. 2007 Sep;81(18):9737-47
pubmed: 17609271
J Virol. 2011 Nov;85(21):11220-34
pubmed: 21835787
Science. 2003 Nov 7;302(5647):1056-60
pubmed: 14564014
Sci Transl Med. 2012 Jul 11;4(142):142ra94
pubmed: 22786679
Mol Cell. 2016 May 19;62(4):627-35
pubmed: 27203182
Cancer Discov. 2018 Nov;8(11):1474-1489
pubmed: 30209081
Virology. 2009 Sep 1;391(2):284-92
pubmed: 19596386
Cell. 2018 Dec 13;175(7):1917-1930.e13
pubmed: 30550789
Elife. 2018 Sep 20;7:
pubmed: 30234487
Mol Aspects Med. 2010 Oct;31(5):383-97
pubmed: 20538015
Nature. 2011 Dec 21;481(7381):376-9
pubmed: 22190036
PLoS Pathog. 2009 Jul;5(7):e1000530
pubmed: 19649319
Mol Cell. 2013 Mar 7;49(5):884-96
pubmed: 23416107
PLoS Pathog. 2012 Dec;8(12):e1003085
pubmed: 23300442
Curr Opin Virol. 2016 Apr;17:1-10
pubmed: 26426962
Mol Syst Biol. 2017 Mar 27;13(3):922
pubmed: 28348067
Methods Enzymol. 2005;398:9-20
pubmed: 16275315
Nat Methods. 2011 Jan;8(1):70-3
pubmed: 21131968
Mol Cell. 2003 Dec;12(6):1427-37
pubmed: 14690597
Science. 1995 Sep 8;269(5229):1439-43
pubmed: 7660129
Cell Host Microbe. 2011 Mar 17;9(3):235-242
pubmed: 21396898
Immunology. 2011 Feb;132(2):157-64
pubmed: 21091910

Auteurs

Ruth Hüttenhain (R)

Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institutes, San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), San Francisco, CA 94158, USA. Electronic address: ruth.huttenhain@ucsf.edu.

Jiewei Xu (J)

Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institutes, San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), San Francisco, CA 94158, USA.

Lily A Burton (LA)

Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143, USA.

David E Gordon (DE)

Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institutes, San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), San Francisco, CA 94158, USA.

Judd F Hultquist (JF)

Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institutes, San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), San Francisco, CA 94158, USA; Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Jeffrey R Johnson (JR)

Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institutes, San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), San Francisco, CA 94158, USA.

Laura Satkamp (L)

Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institutes, San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), San Francisco, CA 94158, USA.

Joseph Hiatt (J)

Gladstone Institutes, San Francisco, CA 94158, USA; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.

David Y Rhee (DY)

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Kheewoong Baek (K)

Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

David C Crosby (DC)

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.

Alan D Frankel (AD)

Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.

Alexander Marson (A)

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

J Wade Harper (JW)

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Arno F Alpi (AF)

Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

Brenda A Schulman (BA)

Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

John D Gross (JD)

Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143, USA.

Nevan J Krogan (NJ)

Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA; Gladstone Institutes, San Francisco, CA 94158, USA; Quantitative Biosciences Institute (QBI), San Francisco, CA 94158, USA. Electronic address: nevan.krogan@ucsf.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de restriction antiviraux › APOBEC-3G Deaminase › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Cellules › Cellules cultivées › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Cullines › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › Échappement immunitaire › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Métabolisme › Protéolyse › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › ARIH2 Is a Vif-Dependent Regulator of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Produits du gène vif › Produits du gène vif du virus de l'immunodéficience humaine › ARIH2 Is a Vif-Dependent Regulator of...