A neurotoxin that specifically targets Anopheles mosquitoes.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
28 06 2019
28 06 2019
Historique:
received:
29
11
2018
accepted:
23
05
2019
entrez:
30
6
2019
pubmed:
30
6
2019
medline:
28
8
2019
Statut:
epublish
Résumé
Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets anopheline mosquitoes. Isolation of PMP1 from Paraclostridium bifermentans strains collected in anopheline endemic areas on two continents indicates it is widely distributed. The toxin likely evolved from an ancestral form that targets the nervous system of similar organisms, using a common mechanism that disrupts SNARE-mediated exocytosis. It cleaves the mosquito syntaxin and employs a unique receptor recognition strategy. Our research has an important impact on the study of the evolution of clostridial neurotoxins and provides the basis for the use of P. bifermentans strains and PMP1 as innovative, environmentally friendly approaches to reduce malaria through anopheline control.
Identifiants
pubmed: 31253776
doi: 10.1038/s41467-019-10732-w
pii: 10.1038/s41467-019-10732-w
pmc: PMC6599013
doi:
Substances chimiques
Bacterial Toxins
0
Neurotoxins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2869Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : 1R21AI070873
Pays : International
Organisme : NIAID NIH HHS
ID : R01 AI123390
Pays : United States
Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 2014-5667
Pays : International
Organisme : UC | University of California, Riverside (UC Riverside)
ID : AESMF
Pays : International
Organisme : NIAID NIH HHS
ID : R21 AI070873
Pays : United States
Organisme : NIH HHS
ID : S10 OD010669
Pays : United States
Organisme : ODCDC CDC HHS
ID : S10 OD010669
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : 1 R01AI123390
Pays : International
Références
Appl Environ Microbiol. 2014 Sep;80(18):5689-97
pubmed: 25002432
FEBS J. 2011 Dec;278(23):4506-15
pubmed: 21624052
J Cell Biol. 2010 May 17;189(4):691-700
pubmed: 20457762
Nature. 1992 Oct 29;359(6398):832-5
pubmed: 1331807
Nature. 1991 Oct 31;353(6347):815-21
pubmed: 1658659
Cell Rep. 2014 Sep 25;8(6):1870-1878
pubmed: 25220457
Proteins. 2005 Nov 1;61(2):288-95
pubmed: 16104015
Mol Microbiol. 2004 Feb;51(3):631-43
pubmed: 14731268
PLoS Pathog. 2013;9(10):e1003690
pubmed: 24130488
Nat Commun. 2017 Aug 03;8:14130
pubmed: 28770820
Appl Environ Microbiol. 2015 Jan;81(2):481-91
pubmed: 25362065
J Bacteriol. 1996 Jun;178(11):3099-105
pubmed: 8655486
Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):355-67
pubmed: 21460454
Acta Crystallogr D Biol Crystallogr. 2006 Jan;62(Pt 1):72-82
pubmed: 16369096
C R Acad Sci III. 1990;310(9):383-7
pubmed: 1972899
J Biol Chem. 1994 Apr 29;269(17):12764-72
pubmed: 8175689
FEBS Lett. 2018 Feb;592(3):310-317
pubmed: 29323697
Sci Rep. 2016 Jul 07;6:29538
pubmed: 27383378
Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):12-21
pubmed: 20057044
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5630-5
pubmed: 23509303
Cell Host Microbe. 2018 Feb 14;23(2):169-176.e6
pubmed: 29396040
Gene. 1991 Dec 1;108(1):115-9
pubmed: 1662180
Biochemistry. 1996 Feb 27;35(8):2630-6
pubmed: 8611567
J Biol Chem. 2000 Mar 24;275(12):8889-94
pubmed: 10722735
Science. 2012 Feb 24;335(6071):977-81
pubmed: 22363010
Sci Rep. 2016 Jul 22;6:30257
pubmed: 27443638
Mol Biol Evol. 2004 Feb;21(2):255-65
pubmed: 14660700
Toxicon. 2018 Jun 1;147:19-26
pubmed: 29042313
Science. 2014 Jun 20;344(6190):1405-10
pubmed: 24948737
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
J Biol Chem. 1994 Aug 12;269(32):20213-6
pubmed: 8051110
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
PLoS Pathog. 2018 May 2;14(5):e1007048
pubmed: 29718991
J Am Mosq Control Assoc. 1997 Dec;13(4):395-7
pubmed: 9474569
FEBS Lett. 2017 Nov;591(22):3781-3792
pubmed: 29067689
Nature. 2004 Dec 16;432(7019):925-9
pubmed: 15592454
Tropenmed Parasitol. 1982 Jun;33(2):97-101
pubmed: 7112688
Mol Microbiol. 2011 Jul;81(1):143-56
pubmed: 21542861
J Am Mosq Control Assoc. 1992 Sep;8(3):272-7
pubmed: 1357087
Appl Environ Microbiol. 2012 May;78(9):3120-7
pubmed: 22344654
J Biol Chem. 1994 Jan 21;269(3):1617-20
pubmed: 8294407
Nat Rev Microbiol. 2014 Aug;12(8):535-49
pubmed: 24975322
FEBS Lett. 2015 Jan 30;589(3):342-8
pubmed: 25541486
FEBS J. 2011 Dec;278(23):4467-85
pubmed: 21592305