Chromatin organization in the female mouse brain fluctuates across the oestrous cycle.
Animals
Behavior, Animal
Brain
/ cytology
Chromatin
/ physiology
Early Growth Response Protein 1
/ metabolism
Epigenomics
Estradiol
/ metabolism
Estrous Cycle
/ physiology
Female
Gene Expression Regulation
/ physiology
Male
Mice
Mice, Inbred C57BL
Neurons
/ cytology
Progesterone
/ metabolism
Protein Binding
RNA
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
28 06 2019
28 06 2019
Historique:
received:
03
07
2018
accepted:
23
05
2019
entrez:
30
6
2019
pubmed:
30
6
2019
medline:
20
8
2019
Statut:
epublish
Résumé
Male and female brains differ significantly in both health and disease, and yet the female brain has been understudied. Sex-hormone fluctuations make the female brain particularly dynamic and are likely to confer female-specific risks for neuropsychiatric disorders. The molecular mechanisms underlying the dynamic nature of the female brain structure and function are unknown. Here we show that neuronal chromatin organization in the female ventral hippocampus of mouse fluctuates with the oestrous cycle. We find chromatin organizational changes associated with the transcriptional activity of genes important for neuronal function and behaviour. We link these chromatin dynamics to variation in anxiety-related behaviour and brain structure. Our findings implicate an immediate-early gene product, Egr1, as part of the mechanism mediating oestrous cycle-dependent chromatin and transcriptional changes. This study reveals extreme, sex-specific dynamism of the neuronal epigenome, and establishes a foundation for the development of sex-specific treatments for disorders such as anxiety and depression.
Identifiants
pubmed: 31253786
doi: 10.1038/s41467-019-10704-0
pii: 10.1038/s41467-019-10704-0
pmc: PMC6598989
doi:
Substances chimiques
Chromatin
0
Early Growth Response Protein 1
0
Egr1 protein, mouse
0
Progesterone
4G7DS2Q64Y
Estradiol
4TI98Z838E
RNA
63231-63-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
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