Erythropoietin and caffeine exert similar protective impact against neonatal intermittent hypoxia: Apnea of prematurity and sex dimorphism.
Brainstem
Neuronal maturation
Oxidative stress
ROS
Sex dimorphism
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
02
03
2019
revised:
21
05
2019
accepted:
25
06
2019
pubmed:
30
6
2019
medline:
4
3
2020
entrez:
30
6
2019
Statut:
ppublish
Résumé
Apnea of prematurity (AoP) is associated with severe and repeated episodes of arterial oxygen desaturation (intermittent hypoxia - IH), which in turn increases the number of apneas. So far, there is no data addressing whether IH leads to sex-specific respiratory consequences, neither if drugs targeting AoP are more effective in males or females. We used rat pups for investigating whether IH-mediated increase of apneas is sex-specific. We also tested whether caffeine (treatment of choice of AoP), erythropoietin (Epo - a neuroprotective factor and potent respiratory stimulant), and combination of both (caffeine+Epo) prevent the IH-mediated formation of apneas in a sex-dependent manner. Newborn rats exposed to IH (21% - 10% FIO
Identifiants
pubmed: 31254520
pii: S0014-4886(19)30137-2
doi: 10.1016/j.expneurol.2019.112985
pii:
doi:
Substances chimiques
Neuroprotective Agents
0
Erythropoietin
11096-26-7
Caffeine
3G6A5W338E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112985Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.