The sooner, the later - Delayed diagnosis in Parkinson's disease due to Parkin mutations.

Adult Age of Onset Delayed Diagnosis Female Humans Male Middle Aged Parkinson Disease / diagnosis Ubiquitin-Protein Ligases / genetics
Diagnostic delay EO-PD Genetic testing Parkin Parkinson's disease

Journal

Parkinsonism & related disorders
ISSN: 1873-5126
Titre abrégé: Parkinsonism Relat Disord
Pays: England
ID NLM: 9513583

Informations de publication

Date de publication:
08 2019
Historique:
received: 20 03 2019
revised: 15 06 2019
accepted: 22 06 2019
pubmed: 1 7 2019
medline: 1 7 2020
entrez: 1 7 2019
Statut: ppublish

Résumé

The diagnosis of Parkinson's disease (PD) in patients carrying mutations in the Parkin gene is frequently delayed. We confirmed this finding in a sample of nine biallelic Parkin-PD patients with a mean delay of nine years and found an inverse relationship between diagnostic delay and age at onset.

Identifiants

DOI: 10.1016/j.parkreldis.2019.06.020 PMID: 31255538
pubmed: 31255538
pii: S1353-8020(19)30283-4
doi: 10.1016/j.parkreldis.2019.06.020
pii:
doi:

Substances chimiques

Ubiquitin-Protein Ligases EC 2.3.2.27
parkin protein EC 2.3.2.27

Types de publication

Letter Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

284-285

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Max Borsche (M)

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany; Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck, Germany. Electronic address: max.borsche@neuro.uni-luebeck.de.

Alexander Balck (A)

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany; Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck, Germany. Electronic address: alexander.balck@neuro.uni-luebeck.de.

Meike Kasten (M)

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address: meike.kasten@neuro.uni-luebeck.de.

Katja Lohmann (K)

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

Christine Klein (C)

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. Electronic address: christine.klein@neuro.uni-luebeck.de.

Norbert Brüggemann (N)

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany; Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck, Germany. Electronic address: norbert.brueggemann@neuro.uni-luebeck.de.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › The sooner, the later - Delayed diagnosis in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Âge de début › The sooner, the later - Delayed diagnosis in...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Retard de diagnostic › The sooner, the later - Delayed diagnosis in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The sooner, the later - Delayed diagnosis in...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The sooner, the later - Delayed diagnosis in...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › The sooner, the later - Delayed diagnosis in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › The sooner, the later - Delayed diagnosis in...