Gambierol Potently Increases Evoked Quantal Transmitter Release and Reverses Pre- and Post-Synaptic Blockade at Vertebrate Neuromuscular Junctions.

Action Potentials Animals Ciguatoxins Neuromuscular Junction Synaptic Transmission Vertebrates
Ca(2+) transients botulinum type A neurotoxin marine biotoxin nerve terminal potassium current quantal transmitter release

Journal

Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074

Informations de publication

Date de publication:
15 07 2020
Historique:
received: 14 04 2019
revised: 15 06 2019
accepted: 18 06 2019
pubmed: 1 7 2019
medline: 15 5 2021
entrez: 1 7 2019
Statut: ppublish

Résumé

Gambierol is a marine polycyclic ether toxin, first isolated from cultured Gambierdiscus toxicus dinoflagellates collected in French Polynesia. The chemical synthesis of gambierol permitted the analyses of its mode of action which includes the selective inhibition of voltage-gated K

Identifiants

DOI: 10.1016/j.neuroscience.2019.06.024 PMID: 31255710
pubmed: 31255710
pii: S0306-4522(19)30441-5
doi: 10.1016/j.neuroscience.2019.06.024
pii:
doi:

Substances chimiques

gambierol 0
Ciguatoxins 11050-21-8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106-116

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Jordi Molgó (J)

CEA, Institut des sciences du vivant Frédéric Joliot, Service d'Ingénierie Moléculaire des Protéines, Université Paris-Saclay, bâtiment 152, 91191 Gif sur Yvette, France; Institut des Neurosciences Paris-Saclay, UMR 9197 CNRS / Université Paris-Sud, CNRS, Gif sur Yvette, France. Electronic address: jordi.molgo@cea.fr.

Sébastien Schlumberger (S)

Institut des Neurosciences Paris-Saclay, UMR 9197 CNRS / Université Paris-Sud, CNRS, Gif sur Yvette, France.

Makoto Sasaki (M)

Graduate School of Life Sciences, Tohoku University, Sendai, Japan.

Haruhiko Fuwa (H)

Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University 1-13-27 Kasuga, Bunkyo, Tokyo 112-8551, Japan.

M Carmen Louzao (MC)

Departamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo, Spain.

Luis M Botana (LM)

Departamento de Farmacología, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo, Spain.

Denis Servent (D)

CEA, Institut des sciences du vivant Frédéric Joliot, Service d'Ingénierie Moléculaire des Protéines, Université Paris-Saclay, bâtiment 152, 91191 Gif sur Yvette, France.

Evelyne Benoit (E)

CEA, Institut des sciences du vivant Frédéric Joliot, Service d'Ingénierie Moléculaire des Protéines, Université Paris-Saclay, bâtiment 152, 91191 Gif sur Yvette, France; Institut des Neurosciences Paris-Saclay, UMR 9197 CNRS / Université Paris-Sud, CNRS, Gif sur Yvette, France.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › Gambierol Potently Increases Evoked Quantal...
questionsmedicales.fr › Eucaryotes › Animaux › Gambierol Potently Increases Evoked Quantal...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines de la flore et de la faune marines › Ciguatoxines › Gambierol Potently Increases Evoked Quantal...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Synapse neuro-effectrice › Jonction neuromusculaire › Gambierol Potently Increases Evoked Quantal...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Gambierol Potently Increases Evoked Quantal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Gambierol Potently Increases Evoked Quantal...