Relationship between Structural Characteristics and Plant Sources along with Pharmacology Research of Quassinoids.
anti-cancer mechanism
plant source
quassinoid
structural characteristic
structure–activity relationship (SAR)
Journal
Chemical & pharmaceutical bulletin
ISSN: 1347-5223
Titre abrégé: Chem Pharm Bull (Tokyo)
Pays: Japan
ID NLM: 0377775
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
2
7
2019
pubmed:
2
7
2019
medline:
4
7
2019
Statut:
ppublish
Résumé
Quassinoids, one kind of triterpenoids with multiple bioactivities such as anti-cancer, anti-malarial, anti-oxidative, anti-microbial, anti-diabetic, anti-viral, and anti-inflammatory effects, have drawn much attention in recent years. Between 2004 and 2018, the structural characteristics and plant sources of 190 quassinoids were reported. Herein, the structure-activity relationships (SARs) of quassinoids along with the anti-cancer mechanisms of four representative quassinoids, eurycomanone, bruceine D, dehydrobruceine B, and brusatol are discussed. This review might be useful for further research and development of quassinoids.
Identifiants
pubmed: 31257321
doi: 10.1248/cpb.c18-00958
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Antiprotozoal Agents
0
Antiviral Agents
0
Quassins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM