Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats.

Animals Area Under Curve Brain / metabolism Cholinesterase Inhibitors / administration & dosage Male Rats Rats, Wistar Tacrine / administration & dosage Time Factors Tissue Distribution
7-methoxytacrine Alzheimer’s disease Tacrine acetylcholinesterase inhibitors blood biochemistry blood-brain barrier organ toxicity

Journal

Drug and chemical toxicology
ISSN: 1525-6014
Titre abrégé: Drug Chem Toxicol
Pays: United States
ID NLM: 7801723

Informations de publication

Date de publication:
Mar 2021
Historique:
pubmed: 2 7 2019
medline: 2 10 2021
entrez: 2 7 2019
Statut: ppublish

Résumé

The search for tacrine derivatives, as potential Alzheimer´s disease treatment, is still being at the forefront of scientific efforts. 7-MEOTA was found to be a potent, centrally active acetylcholinesterase inhibitor free of the serious side effects observed for tacrine. Unfortunately, a relevant argumentation about pharmacokinetics and potential toxicity is incomplete; information about tacrine derivatives absorption and especially CNS penetration are still rare as well as detailed toxicological profile

Identifiants

DOI: 10.1080/01480545.2019.1566350 PMID: 31257938
pubmed: 31257938
doi: 10.1080/01480545.2019.1566350
doi:

Substances chimiques

Cholinesterase Inhibitors 0
Tacrine 4VX7YNB537
7-methoxytacrine 5778-80-3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

207-214

Auteurs

Jana Zdarova Karasova (J)

Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.
Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.

Ondrej Soukup (O)

Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.
Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.
ORCID: 0000-0001-6376-8701

Jan Korabecny (J)

Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.
Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.

Milos Hroch (M)

Faculty of Medicine, Department of Medicinal Biochemistry, Charles University in Prague, Hradec Kralove, Czech Republic.

Marketa Krejciova (M)

Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.

Martina Hrabinova (M)

Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.
Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.

Jan Misik (J)

Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.
Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.

Ladislav Novotny (L)

Finn Pathologists, One Eyed Lane, Weybread, UK.

Vendula Hepnarova (V)

Faculty of Military Health Sciences, Department of Toxicology and Military Pharmacy, University of Defence, Hradec Kralove, Czech Republic.
Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.

Kamil Kuca (K)

Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic.
Faculty of Science, Department of Chemistry, University of Hradec Kralove, Hradec Kralove, Czech Republic.
Department of Cellular Biology and Pharmacology, Florida International University, Miami, FL, USA.
ORCID: 0000-0001-9664-1109

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Tacrine and its 7-methoxy derivate;...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Aire sous la courbe › Tacrine and its 7-methoxy derivate;...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tacrine and its 7-methoxy derivate;...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Tacrine and its 7-methoxy derivate;...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Tacrine and its 7-methoxy derivate;...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Tacrine and its 7-methoxy derivate;...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Acridines › Aminoacridines › Tacrine › Tacrine and its 7-methoxy derivate;...
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Tacrine and its 7-methoxy derivate;...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Tacrine and its 7-methoxy derivate;...