Pharmacokinetics and tolerability of inhaled levodopa from a new dry-powder inhaler in patients with Parkinson's disease.

Parkinson’s disease inhaled levodopa levodopa dry-powder inhalation off periods

Journal

Therapeutic advances in chronic disease
ISSN: 2040-6223
Titre abrégé: Ther Adv Chronic Dis
Pays: United States
ID NLM: 101532140

Informations de publication

Date de publication:
2019
Historique:
received: 28 03 2019
accepted: 23 05 2019
entrez: 2 7 2019
pubmed: 2 7 2019
medline: 2 7 2019
Statut: epublish

Résumé

Inhaled levodopa may quickly resolve off periods in Parkinson's disease. Our aim was to determine the pharmacokinetics and tolerability of a new levodopa dry-powder inhaler. A single-centre, single-ascending, single-dose-response study was performed. Over three visits, eight Parkinson's disease patients (not in the 'off state') received by inhalation 30 mg or 60 mg levodopa, or their regular oral levodopa. Maximum levodopa plasma concentration ( After inhalation, levodopa Inhaled levodopa is well tolerated, absorbed faster than oral levodopa, and can be robustly administered over a range of inhalation flow profiles. It therefore appears suitable for the treatment of off periods in Parkinson's disease.

Sections du résumé

BACKGROUND BACKGROUND
Inhaled levodopa may quickly resolve off periods in Parkinson's disease. Our aim was to determine the pharmacokinetics and tolerability of a new levodopa dry-powder inhaler.
METHODS METHODS
A single-centre, single-ascending, single-dose-response study was performed. Over three visits, eight Parkinson's disease patients (not in the 'off state') received by inhalation 30 mg or 60 mg levodopa, or their regular oral levodopa. Maximum levodopa plasma concentration (
RESULTS RESULTS
After inhalation, levodopa
CONCLUSION CONCLUSIONS
Inhaled levodopa is well tolerated, absorbed faster than oral levodopa, and can be robustly administered over a range of inhalation flow profiles. It therefore appears suitable for the treatment of off periods in Parkinson's disease.

Identifiants

pubmed: 31258882
doi: 10.1177/2040622319857617
pii: 10.1177_2040622319857617
pmc: PMC6589987
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2040622319857617

Déclaration de conflit d'intérêts

Conflict of interest statement: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The employer of PH, AB and HWF receives royalties from the sales of the Cyclops DPI. FG is currently partly employed by PureIMS BV, the manufacturer of the Cyclops DPI.

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Auteurs

Marianne Luinstra (M)

Department of Clinical Pharmacy, Martini Hospital Groningen, Groningen, The Netherlands.

Wijnand Rutgers (W)

Department of Neurology and Clinical Neurophysiology, Martini Hospital Groningen, Groningen, The Netherlands.

Teus van Laar (T)

Department of Neurology, University Medical Centre Groningen, Groningen, The Netherlands.

Floris Grasmeijer (F)

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands.

Anja Begeman (A)

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands.

Valmira Isufi (V)

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands.

Luc Steenhuis (L)

Department of Pulmonary Diseases, Martini Hospital Groningen, Groningen, The Netherlands.

Paul Hagedoorn (P)

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands.

Anne de Boer (A)

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands.

Henderik W Frijlink (HW)

Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands.

Classifications MeSH