Reparative T lymphocytes in organ injury.
Journal
The Journal of clinical investigation
ISSN: 1558-8238
Titre abrégé: J Clin Invest
Pays: United States
ID NLM: 7802877
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
entrez:
2
7
2019
pubmed:
2
7
2019
medline:
20
5
2020
Statut:
ppublish
Résumé
Acute organ injuries such as acute cerebrovascular accidents, myocardial infarction, acute kidney injury, acute lung injury, and others are among the leading causes of death worldwide. Dysregulated or insufficient organ repair mechanisms limit restoration of homeostasis and contribute to chronic organ failure. Studies reveal that both humans and mice harness potent non-stem cells that are capable of directly or indirectly promoting tissue repair. Specific populations of T lymphocytes have emerged as important reparative cells with context-specific actions. These T cells can resolve inflammation and secrete reparative cytokines and growth factors as well as interact with other immune and stromal cells to promote the complex and active process of tissue repair. This Review focuses on the major populations of T lymphocytes known to mediate tissue repair, their reparative mechanisms, and the diseases in which they have been implicated. Elucidating and harnessing the mechanisms that promote the reparative functions of these T cells could greatly improve organ dysfunction after acute injury.
Identifiants
pubmed: 31259743
pii: 124614
doi: 10.1172/JCI124614
pmc: PMC6597230
doi:
pii:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2608-2618Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK104662
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK111209
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131812
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL131812
Pays : United States
Références
J Immunol. 1999 Mar 1;162(5):2546-54
pubmed: 10072494
J Exp Med. 1999 Oct 4;190(7):995-1004
pubmed: 10510089
Eur J Immunol. 2000 Jun;30(6):1538-43
pubmed: 10898488
J Exp Med. 2001 Jun 4;193(11):1285-94
pubmed: 11390435
Curr Opin Pediatr. 2001 Dec;13(6):533-8
pubmed: 11753102
J Exp Med. 2002 Mar 4;195(5):603-16
pubmed: 11877483
Eur J Immunol. 2002 May;32(5):1282-91
pubmed: 11981815
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14338-43
pubmed: 12376619
Curr Opin Immunol. 2002 Dec;14(6):771-8
pubmed: 12413528
J Immunol. 2003 Feb 15;170(4):1659-66
pubmed: 12574328
Nat Rev Immunol. 2003 Mar;3(3):199-210
pubmed: 12658268
J Biol Chem. 2003 Dec 5;278(49):49495-504
pubmed: 14506240
Nat Immunol. 2003 Dec;4(12):1206-12
pubmed: 14578884
Immunol Rev. 2003 Dec;196:109-24
pubmed: 14617201
Cancer Res. 2003 Nov 15;63(22):8014-21
pubmed: 14633734
Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4192-7
pubmed: 15014176
Hepatology. 2004 May;39(5):1332-42
pubmed: 15122762
J Clin Invest. 2004 Jul;114(1):28-38
pubmed: 15232609
Immunity. 2004 Aug;21(2):241-54
pubmed: 15308104
Immunity. 2004 Oct;21(4):503-13
pubmed: 15485628
Nat Immunol. 2005 Jan;6(1):73-9
pubmed: 15592472
J Immunol. 2005 Mar 15;174(6):3695-702
pubmed: 15749908
J Exp Med. 2005 Apr 18;201(8):1269-79
pubmed: 15837812
J Virol. 2005 Jun;79(12):7860-7
pubmed: 15919940
Cell Mol Immunol. 2004 Oct;1(5):328-35
pubmed: 16285891
J Immunol. 2005 Dec 1;175(11):7093-7
pubmed: 16301610
J Exp Med. 2005 Dec 5;202(11):1539-47
pubmed: 16314435
J Exp Med. 2006 Mar 20;203(3):505-11
pubmed: 16533880
Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G827-38
pubmed: 16537974
J Clin Invest. 2006 Apr;116(4):996-1004
pubmed: 16543950
Eur J Immunol. 2006 May;36(5):1309-23
pubmed: 16619290
Clin Exp Immunol. 2006 May;144(2):188-96
pubmed: 16634790
Immunology. 2006 Jun;118(2):240-9
pubmed: 16771859
J Immunol. 2006 Nov 15;177(10):6780-6
pubmed: 17082591
Hepatology. 2006 Dec;44(6):1607-16
pubmed: 17133491
FASEB J. 2007 Feb;21(2):325-32
pubmed: 17267386
J Immunol. 2007 Feb 15;178(4):2229-40
pubmed: 17277128
PLoS Biol. 2007 Feb;5(2):e38
pubmed: 17298177
Biochem Biophys Res Commun. 2007 Jun 15;357(4):1046-52
pubmed: 17462597
J Exp Med. 2007 Jun 11;204(6):1257-65
pubmed: 17502665
Immunol Res. 2007;38(1-3):112-21
pubmed: 17917016
Nat Immunol. 2007 Dec;8(12):1353-62
pubmed: 17982458
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19446-51
pubmed: 18042719
Arthritis Rheum. 2007 Dec;56(12):4104-12
pubmed: 18050211
Nat Immunol. 2008 Feb;9(2):194-202
pubmed: 18157133
J Clin Invest. 2008 Feb;118(2):534-44
pubmed: 18172556
Nat Med. 2008 Mar;14(3):282-9
pubmed: 18264109
Nat Med. 2008 Mar;14(3):275-81
pubmed: 18264110
Annu Rev Immunol. 1991;9:679-705
pubmed: 1832874
Immunity. 2008 Apr;28(4):546-58
pubmed: 18387831
Nat Rev Immunol. 2008 Jul;8(7):523-32
pubmed: 18566595
J Leukoc Biol. 2008 Dec;84(6):1400-9
pubmed: 18765477
Cancer Immunol Immunother. 2009 May;58(5):709-18
pubmed: 18836718
Immunity. 2008 Dec 19;29(6):947-57
pubmed: 19100701
Immunol Lett. 2009 Feb 21;122(2):198-207
pubmed: 19200442
J Exp Med. 2009 Apr 13;206(4):743-50
pubmed: 19307328
J Mol Med (Berl). 2009 May;87(5):523-36
pubmed: 19330474
Immunity. 2009 Jun 19;30(6):899-911
pubmed: 19464196
Immunity. 2009 May;30(5):636-45
pubmed: 19464986
J Am Soc Nephrol. 2009 Aug;20(8):1744-53
pubmed: 19497969
Int Immunopharmacol. 2009 May;9(5):549-52
pubmed: 19539564
J Immunol. 2009 Oct 1;183(7):4675-81
pubmed: 19734235
J Clin Invest. 2009 Oct;119(10):2898-913
pubmed: 19770521
Eur J Immunol. 2009 Dec;39(12):3570-81
pubmed: 19830738
Diabetes. 2010 Feb;59(2):433-9
pubmed: 19934002
Nature. 2010 Feb 11;463(7282):808-12
pubmed: 20072126
Am J Pathol. 2010 May;176(5):2177-87
pubmed: 20382703
Autoimmun Rev. 2010 Jun;9(8):560-8
pubmed: 20385256
J Immunol. 2010 May 15;184(10):5791-801
pubmed: 20393138
Blood. 2010 Aug 12;116(6):935-44
pubmed: 20448110
Kidney Int. 2010 Dec;78(11):1100-9
pubmed: 20463654
PLoS One. 2010 Jul 02;5(7):e11427
pubmed: 20625402
J Exp Med. 2010 Sep 27;207(10):2239-53
pubmed: 20855496
Nat Immunol. 2010 Dec;11(12):1093-101
pubmed: 20953201
Eur J Immunol. 2011 Jun;41(6):1652-62
pubmed: 21469116
Nat Immunol. 2011 May;12(5):383-90
pubmed: 21502992
Gastroenterology. 2011 Nov;141(5):1897-906
pubmed: 21708106
Semin Immunol. 2011 Jun;23(3):202-8
pubmed: 21840222
Nat Med. 2011 Nov 20;17(12):1594-601
pubmed: 22101767
N Engl J Med. 2011 Dec 1;365(22):2055-66
pubmed: 22129252
Kidney Int. 2012 May;81(10):983-992
pubmed: 22189844
Mucosal Immunol. 2012 Mar;5(2):161-72
pubmed: 22236998
Cancer Immunol Immunother. 2012 Nov;61(11):1965-75
pubmed: 22527243
Front Immunol. 2012 Feb 29;3:30
pubmed: 22566914
PLoS One. 2012;7(6):e39072
pubmed: 22720031
J Am Soc Nephrol. 2012 Sep;23(9):1528-37
pubmed: 22835488
Science. 2012 Jul 27;337(6093):431-5
pubmed: 22837519
Gastroenterology. 2012 Nov;143(5):1207-1217.e2
pubmed: 22885333
Cytokine Growth Factor Rev. 2013 Feb;24(1):51-7
pubmed: 22906768
J Immunol. 2012 Oct 1;189(7):3669-80
pubmed: 22933625
J Exp Med. 2012 Sep 24;209(10):1713-22, S1-19
pubmed: 22966003
Am J Respir Cell Mol Biol. 2013 Jan;48(1):35-43
pubmed: 23002097
Gastroenterology. 2012 Dec;143(6):1670-80
pubmed: 23022954
Cell Mol Immunol. 2013 Jan;10(1):50-7
pubmed: 23064104
Arthritis. 2012;2012:805875
pubmed: 23133752
J Invest Dermatol. 2013 May;133(5):1321-9
pubmed: 23223145
Immunity. 2013 Feb 21;38(2):275-84
pubmed: 23333074
Front Immunol. 2013 Jan 24;4:6
pubmed: 23355840
J Immunol. 2013 Mar 1;190(5):2001-8
pubmed: 23359504
Immunol Rev. 2013 Mar;252(1):116-32
pubmed: 23405899
FASEB J. 2013 Jun;27(6):2207-19
pubmed: 23413361
Nat Immunol. 2013 Apr;14(4):307-8
pubmed: 23507634
Nat Med. 2013 Jun;19(6):739-46
pubmed: 23624599
Mucosal Immunol. 2014 Jan;7(1):134-42
pubmed: 23695512
Front Immunol. 2013 Jun 19;4:152
pubmed: 23801990
PLoS One. 2013 Jun 21;8(6):e66613
pubmed: 23805247
World J Gastroenterol. 2013 Jul 7;19(25):3931-41
pubmed: 23840137
J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:56-60
pubmed: 23855297
Hepatology. 2014 Feb;59(2):630-42
pubmed: 23959575
J Clin Invest. 2013 Oct;123(10):4364-74
pubmed: 24051381
Eur J Immunol. 2014 Jan;44(1):103-14
pubmed: 24114149
Cell. 2013 Dec 5;155(6):1282-95
pubmed: 24315098
Front Immunol. 2014 Feb 11;5:46
pubmed: 24575095
Clin Exp Immunol. 2014 Aug;177(2):531-43
pubmed: 24749746
Circ Res. 2014 Jun 20;115(1):55-67
pubmed: 24786398
Mucosal Immunol. 2014 Nov;7(6):1440-51
pubmed: 24850425
Nature. 2014 Sep 25;513(7519):564-568
pubmed: 25043027
J Leukoc Biol. 2014 Nov;96(5):809-20
pubmed: 25082151
Tissue Eng Part A. 2015 Feb;21(3-4):498-509
pubmed: 25159486
Adv Exp Med Biol. 2014;841:209-30
pubmed: 25261209
Am J Respir Cell Mol Biol. 2015 May;52(5):603-10
pubmed: 25275926
Am J Respir Cell Mol Biol. 2015 May;52(5):641-52
pubmed: 25295995
Mol Immunol. 2015 Feb;63(2):420-7
pubmed: 25315497
J Immunol. 2015 Jan 1;194(1):325-33
pubmed: 25404361
Metab Brain Dis. 2015 Aug;30(4):911-924
pubmed: 25537181
Clin Sci (Lond). 2015 May 1;128(10):679-93
pubmed: 25558978
Neuron. 2015 Feb 18;85(4):703-9
pubmed: 25661185
Immunity. 2015 Feb 17;42(2):216-226
pubmed: 25692699
PLoS One. 2015 Apr 30;10(4):e0124927
pubmed: 25928296
Cell Immunol. 2015 Jul;296(1):57-61
pubmed: 25958272
J Am Soc Nephrol. 2016 Apr;27(4):1113-23
pubmed: 26315532
Cell. 2015 Aug 27;162(5):1078-89
pubmed: 26317471
J Leukoc Biol. 2016 Feb;99(2):373-86
pubmed: 26428678
Methods Mol Biol. 2016;1371:29-41
pubmed: 26530793
Front Immunol. 2015 Oct 19;6:494
pubmed: 26539191
J Immunol. 2016 Mar 1;196(5):2010-4
pubmed: 26826250
Immunity. 2016 Feb 16;44(2):355-67
pubmed: 26872699
J Mol Med (Berl). 2016 May;94(5):523-34
pubmed: 26923718
Trends Immunol. 2016 May;37(5):321-333
pubmed: 27055914
Oncoimmunology. 2015 Sep 02;5(8):e1082704
pubmed: 27622053
Trends Immunol. 2016 Nov;37(11):803-811
pubmed: 27623114
Nat Rev Immunol. 2016 Nov;16(11):676-689
pubmed: 27640624
Nat Rev Immunol. 2017 Mar;17(3):165-178
pubmed: 28163303
Front Immunol. 2017 Jan 23;8:31
pubmed: 28167946
Nat Neurosci. 2017 May;20(5):674-680
pubmed: 28288125
Am J Respir Cell Mol Biol. 2017 Aug;57(2):162-173
pubmed: 28296468
Kidney Int. 2017 Aug;92(2):415-431
pubmed: 28396117
Nat Immunol. 2017 Jul;18(7):771-779
pubmed: 28530714
J Am Soc Nephrol. 2017 Sep;28(9):2681-2693
pubmed: 28539382
Cell. 2017 Jun 1;169(6):1119-1129.e11
pubmed: 28552347
J Clin Invest. 2017 Sep 1;127(9):3510-3520
pubmed: 28783045
Nat Rev Immunol. 2018 Jan;18(1):62-76
pubmed: 28853443
Am J Physiol Renal Physiol. 2018 May 1;314(5):F679-F698
pubmed: 28877881
Nat Rev Immunol. 2017 Dec;17(12):733-745
pubmed: 28920588
Clin Cancer Res. 2018 Jan 15;24(2):370-382
pubmed: 29074605
JCI Insight. 2017 Nov 2;2(21):
pubmed: 29093262
J Transl Med. 2018 Jan 10;16(1):3
pubmed: 29316940
Immunity. 2018 Feb 20;48(2):202-213
pubmed: 29466753
Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2585-E2593
pubmed: 29476012
Oncol Lett. 2018 Jun;15(6):8187-8194
pubmed: 29805553
Cell Rep. 2018 Aug 7;24(6):1610-1626
pubmed: 30089270
Cell Physiol Biochem. 2018;49(1):349-358
pubmed: 30138941
Cell. 2018 Aug 23;174(5):1054-1066
pubmed: 30142344
Science. 2018 Oct 12;362(6411):154-155
pubmed: 30309932
Stem Cells Dev. 2019 Jan 15;28(2):129-140
pubmed: 30381994
J Am Soc Nephrol. 2019 Feb;30(2):277-292
pubmed: 30622155
JCI Insight. 2019 Mar 21;4(6):null
pubmed: 30779711
Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5558-5563
pubmed: 30819895
Immunology. 2019 Jun;157(2):151-162
pubmed: 30919408
Science. 1994 Nov 18;266(5188):1253-5
pubmed: 7973709
Eur J Immunol. 1996 Jun;26(6):1273-7
pubmed: 8647204
J Immunol. 1996 Aug 1;157(3):985-92
pubmed: 8757601
Nature. 1997 Oct 16;389(6652):737-42
pubmed: 9338786