Fluorescence-labeled neopeltolide derivatives for subcellular localization imaging.

A549 Cells Cell Proliferation / drug effects Cell Survival / drug effects Dose-Response Relationship, Drug Endoplasmic Reticulum / chemistry Fluorescence Fluorescent Dyes / chemical synthesis Humans Macrolides / chemical synthesis Mitochondria / chemistry Molecular Conformation Optical Imaging Tissue Distribution

Journal

Organic & biomolecular chemistry
ISSN: 1477-0539
Titre abrégé: Org Biomol Chem
Pays: England
ID NLM: 101154995

Informations de publication

Date de publication:
17 07 2019
Historique:
pubmed: 2 7 2019
medline: 23 1 2020
entrez: 2 7 2019
Statut: ppublish

Résumé

Design, synthesis and functional analysis of fluorescent derivatives of neopeltolide, an antiproliferative marine macrolide, are reported herein. Live cell imaging using the fluorescent derivatives showed rapid cellular uptake and localization within the endoplasmic reticulum as well as the mitochondria.

Identifiants

DOI: 10.1039/c9ob01276a PMID: 31259993
pubmed: 31259993
doi: 10.1039/c9ob01276a
doi:

Substances chimiques

Fluorescent Dyes 0
Macrolides 0
neopeltolide 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6771-6776

Auteurs

Shota Yanagi (S)

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.

Tomoya Sugai (T)

Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. hfuwa.50m@g.chuo-u.ac.jp.

Takuma Noguchi (T)

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.

Masato Kawakami (M)

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.

Makoto Sasaki (M)

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.

Shinsuke Niwa (S)

Frontier Research Institute for Interdisciplinary Sciences (FRIS), Tohoku University, 6-3 Aramaki Aoba, Aoba-ku, Sendai, Miyagi 980-0845, Japan.

Asako Sugimoto (A)

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.

Haruhiko Fuwa (H)

Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan. hfuwa.50m@g.chuo-u.ac.jp.
ORCID: 0000-0001-5343-9023

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules A549 › Fluorescence-labeled neopeltolide derivatives...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Fluorescence-labeled neopeltolide derivatives...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Fluorescence-labeled neopeltolide derivatives...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Fluorescence-labeled neopeltolide derivatives...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › Fluorescence-labeled neopeltolide derivatives...
questionsmedicales.fr › Phénomènes physiques › Phénomènes optiques › Fluorescence › Fluorescence-labeled neopeltolide derivatives...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Fluorescence-labeled neopeltolide derivatives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fluorescence-labeled neopeltolide derivatives...
questionsmedicales.fr › Composés polycycliques › Composés macrocycliques › Polycétides › Macrolides › Fluorescence-labeled neopeltolide derivatives...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Fluorescence-labeled neopeltolide derivatives...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Fluorescence-labeled neopeltolide derivatives...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Fluorescence-labeled neopeltolide derivatives...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Fluorescence-labeled neopeltolide derivatives...