A 17-marker panel for global genomic instability in breast cancer.
Breast cancer signature
Genomic instability
Outcome prediction
Prognostic biomarkers
Journal
Genomics
ISSN: 1089-8646
Titre abrégé: Genomics
Pays: United States
ID NLM: 8800135
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
23
04
2019
revised:
19
06
2019
accepted:
27
06
2019
pubmed:
2
7
2019
medline:
5
1
2021
entrez:
2
7
2019
Statut:
ppublish
Résumé
Genomic instability is a hallmark of cancer that plays a pivotal role in breast cancer development and evolution. A number of existing prognostic gene expression signatures for breast cancer are based on proliferation-related genes. Here, we identified a 17-marker panel associated with genome stability. A total of 136 primary breast carcinomas were stratified by genome stability. Matched gene expression profiles showed an innate segregation based on genome stability. We identified a 17-marker panel stratifying the training and validation cohorts into high- and low-risk patients. The 17 genes associated with genomic instability strongly impacted clinical outcome in breast cancer. Pathway analyses determined chromosome organisation, cell cycle regulation, and RNA processing as the underlying biological processes, thereby offering options for drug development and treatment tailoring. Our work supports the applicability of the 17-marker panel to improve clinical outcome prediction for breast cancer patients based on a signature accounting for genomic instability.
Identifiants
pubmed: 31260745
pii: S0888-7543(19)30225-3
doi: 10.1016/j.ygeno.2019.06.029
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1151-1161Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.