Photosensitive Melanopsin-Containing Retinal Ganglion Cells in Health and Disease: Implications for Circadian Rhythms.
P23H
Parkinson disease
aging
circadian rhythms
ipRGCs
retinitis pigmentosa
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Jun 2019
28 Jun 2019
Historique:
received:
16
05
2019
revised:
26
06
2019
accepted:
26
06
2019
entrez:
3
7
2019
pubmed:
3
7
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Melanopsin-containing retinal ganglion cells (mRGCs) represent a third class of retinal photoreceptors involved in regulating the pupillary light reflex and circadian photoentrainment, among other things. The functional integrity of the circadian system and melanopsin cells is an essential component of well-being and health, being both impaired in aging and disease. Here we review evidence of melanopsin-expressing cell alterations in aging and neurodegenerative diseases and their correlation with the development of circadian rhythm disorders. In healthy humans, the average density of melanopsin-positive cells falls after age 70, accompanied by age-dependent atrophy of dendritic arborization. In addition to aging, inner and outer retinal diseases also involve progressive deterioration and loss of mRGCs that positively correlates with progressive alterations in circadian rhythms. Among others, mRGC number and plexus complexity are impaired in Parkinson's disease patients; changes that may explain sleep and circadian rhythm disorders in this pathology. The key role of mRGCs in circadian photoentrainment and their loss in age and disease endorse the importance of eye care, even if vision is lost, to preserve melanopsin ganglion cells and their essential functions in the maintenance of an adequate quality of life.
Identifiants
pubmed: 31261700
pii: ijms20133164
doi: 10.3390/ijms20133164
pmc: PMC6651433
pii:
doi:
Substances chimiques
Rod Opsins
0
melanopsin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerio de Economia y Competitividad
ID : MINECO-FEDER-BFU2015-67139-R
Organisme : Ministerio de Educación, Cultura y Deporte
ID : FPU14/03166
Organisme : Instituto de Salud Carlos III
ID : RETICS-FEDER RD16/0008/0016
Organisme : Instituto de Salud Carlos III
ID : RD16/0008/0026
Organisme : Generalitat Valenciana
ID : PROMETEO/2016/158
Références
J Neurosci. 2000 Jan 15;20(2):600-5
pubmed: 10632589
Chronobiol Int. 2000 May;17(3):233-43
pubmed: 10841205
Chronobiol Int. 2000 May;17(3):369-90
pubmed: 10841211
Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3200-9
pubmed: 10967084
Life Sci. 2000 Aug 18;67(13):1549-58
pubmed: 10983850
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11020-5
pubmed: 10995468
Arch Gen Psychiatry. 2001 Apr;58(4):353-60
pubmed: 11296096
J Sleep Res. 2001 Jun;10(2):159-64
pubmed: 11422730
Neurophysiol Clin. 2001 Jun;31(3):161-70
pubmed: 11488227
J Hum Hypertens. 2001 Aug;15(8):577-81
pubmed: 11494098
J Neurosci. 2002 Jan 1;22(1):RC191
pubmed: 11756521
Nature. 2002 Jan 31;415(6871):493
pubmed: 11823848
Science. 2002 Feb 8;295(5557):1065-70
pubmed: 11834834
Science. 2002 Feb 8;295(5557):1070-3
pubmed: 11834835
J Sleep Res. 2001 Dec;10(4):329-35
pubmed: 11903863
Ann Med. 2002;34(5):401-7
pubmed: 12452484
Science. 2002 Dec 13;298(5601):2213-6
pubmed: 12481141
Ann N Y Acad Sci. 2003 Jun;991:1-14
pubmed: 12846969
Prog Retin Eye Res. 2003 Sep;22(5):607-55
pubmed: 12892644
Neuroscience. 2004;127(2):301-17
pubmed: 15262321
Vision Res. 2004 Oct;44(23):2667-74
pubmed: 15358062
Nature. 2005 Feb 17;433(7027):749-54
pubmed: 15716953
Eur J Neurosci. 2005 Dec;22(12):3129-36
pubmed: 16367779
Invest Ophthalmol Vis Sci. 2006 Jul;47(7):2951-8
pubmed: 16799038
Prog Brain Res. 2006;153:253-69
pubmed: 16876580
J Biosci. 2007 Mar;32(2):293-8
pubmed: 17435321
Curr Biol. 2007 Jun 5;17(11):981-8
pubmed: 17524644
Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2824-30
pubmed: 17525218
Dialogues Clin Neurosci. 2007;9(3):301-14
pubmed: 17969867
Eur J Neurosci. 2007 Nov;26(10):2906-21
pubmed: 18001286
J Circadian Rhythms. 2008 Jan 10;6:1
pubmed: 18186932
Eur J Neurosci. 2008 Apr;27(7):1763-70
pubmed: 18371076
Cell Mol Neurobiol. 2008 Dec;28(8):1095-107
pubmed: 18512147
Exp Gerontol. 2009 Jan-Feb;44(1-2):51-6
pubmed: 18579326
Hum Psychopharmacol. 2008 Oct;23(7):571-85
pubmed: 18680211
Nat Rev Genet. 2008 Oct;9(10):764-75
pubmed: 18802415
Parkinsonism Relat Disord. 2009 Jul;15(6):471-4
pubmed: 19041273
PLoS One. 2008;3(12):e3931
pubmed: 19079596
Gerontology. 2010;56(2):181-9
pubmed: 19738366
Neurobiol Dis. 2010 Apr;38(1):47-58
pubmed: 20060471
Mov Disord. 2010;25 Suppl 1:S117-22
pubmed: 20187236
Adv Exp Med Biol. 2010;664:525-32
pubmed: 20238055
J Comp Neurol. 2010 Jun 1;518(11):2071-89
pubmed: 20394059
Neurobiol Aging. 2012 Feb;33(2):383-92
pubmed: 20409612
J Comp Neurol. 2010 Jul 1;518(13):2405-22
pubmed: 20503419
Neuron. 2010 Jul 15;67(1):49-60
pubmed: 20624591
Nat Rev Neurosci. 2010 Aug;11(8):589-99
pubmed: 20631712
Exp Eye Res. 2010 Nov;91(5):578-83
pubmed: 20692255
Exp Eye Res. 2010 Dec;91(6):800-10
pubmed: 20955700
Int J Neurosci. 2011 Jan;121(1):37-43
pubmed: 21034369
J Pineal Res. 2011 Mar;50(2):183-91
pubmed: 21062354
PLoS Biol. 2010 Dec 07;8(12):e1000558
pubmed: 21151887
J Physiol. 2011 Mar 1;589(Pt 5):1173-94
pubmed: 21224225
Nature. 1990 Jan 25;343(6256):364-6
pubmed: 2137202
J Neurochem. 2011 Jun;117(5):904-14
pubmed: 21446997
J Comp Neurol. 2011 Jun 1;519(8):1492-504
pubmed: 21452206
Neurobiol Dis. 2011 Oct;44(1):102-15
pubmed: 21742033
Nature. 2011 Jul 17;476(7358):92-5
pubmed: 21765429
Trends Neurosci. 2011 Nov;34(11):572-80
pubmed: 21816493
Exp Neurol. 2011 Nov;232(1):66-75
pubmed: 21864527
J Neurosci. 2011 Nov 2;31(44):16033-44
pubmed: 22049445
J Neurosci. 2011 Nov 9;31(45):16094-101
pubmed: 22072661
Eur J Neurosci. 2012 Feb;35(4):507-18
pubmed: 22304466
Chronobiol Int. 2012 Mar;29(2):147-56
pubmed: 22324553
BMC Ophthalmol. 2012 Apr 03;12:4
pubmed: 22471313
Prog Brain Res. 2012;199:19-40
pubmed: 22877657
Exp Neurol. 2013 May;243:45-56
pubmed: 22935723
J Neurosci. 2012 Sep 26;32(39):13608-20
pubmed: 23015450
Nature. 2012 Nov 22;491(7425):537-8
pubmed: 23151474
Nature. 2012 Nov 22;491(7425):594-8
pubmed: 23151476
Exp Eye Res. 2013 Mar;108:84-93
pubmed: 23295345
J Neurophysiol. 2013 Apr;109(7):1876-89
pubmed: 23343892
Chronobiol Int. 2013 May;30(4):583-97
pubmed: 23445511
Invest Ophthalmol Vis Sci. 2013 Jul 10;54(7):4605-18
pubmed: 23766478
J Clin Sleep Med. 2013 Nov 15;9(11):1119-29
pubmed: 24235892
J Physiol. 2014 Apr 1;592(7):1619-36
pubmed: 24396062
J Parkinsons Dis. 2014;4(2):197-204
pubmed: 24518436
PLoS One. 2014 Mar 26;9(3):e93274
pubmed: 24671191
Neurosci Lett. 2014 Jun 13;571:34-8
pubmed: 24785101
Neuron. 2014 May 21;82(4):781-8
pubmed: 24853938
J Biol Rhythms. 2014 Jun 10;29(3):215-224
pubmed: 24916394
PLoS One. 2014 Jul 09;9(7):e101584
pubmed: 25006976
Prog Retin Eye Res. 2014 Nov;43:17-75
pubmed: 25038518
Chronobiol Int. 2015 Mar;32(2):152-63
pubmed: 25238585
Front Neuroanat. 2014 Oct 06;8:99
pubmed: 25339868
Nat Rev Neurol. 2014 Dec;10(12):683-93
pubmed: 25385339
Neuroscience. 2015 Feb 12;286:60-78
pubmed: 25433236
Neuroscience. 2015 Jan 22;284:845-53
pubmed: 25446359
Exp Eye Res. 2015 Jan;130:17-28
pubmed: 25450063
Front Neuroanat. 2014 Nov 20;8:131
pubmed: 25477787
Invest Ophthalmol Vis Sci. 2015 Feb 26;56(3):1924-36
pubmed: 25722208
Exp Mol Med. 2015 Mar 13;47:e148
pubmed: 25766617
Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4592-604
pubmed: 26200499
Mov Disord. 2015 Oct;30(12):1591-601
pubmed: 26474316
Prog Brain Res. 2015;220:1-35
pubmed: 26497783
Ann Neurol. 2016 Jan;79(1):90-109
pubmed: 26505992
J Neurosci. 2015 Dec 2;35(48):15955-70
pubmed: 26631476
Neuropsychologia. 2016 Jan 8;80:176-184
pubmed: 26631540
Eye (Lond). 2016 Feb;30(2):247-54
pubmed: 26768919
Mol Med Rep. 2016 Apr;13(4):3397-400
pubmed: 26935586
J Comp Neurol. 2016 Oct 1;524(14):2845-72
pubmed: 26972791
Chronobiol Int. 2016;33(4):374-91
pubmed: 27003747
Exp Eye Res. 2016 Sep;150:149-65
pubmed: 27020758
Acta Neurol Scand. 2017 Mar;135(3):273-284
pubmed: 27273099
Brain. 2016 Nov 1;139(11):2827-2843
pubmed: 27412389
Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):4661-7
pubmed: 27583827
PLoS One. 2016 Sep 16;11(9):e0162476
pubmed: 27636197
Science. 2016 Nov 25;354(6315):1004-1008
pubmed: 27885006
Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6652-6661
pubmed: 27930778
J Comp Neurol. 2019 Jan 1;527(1):312-327
pubmed: 28097654
J Clin Invest. 2017 Feb 1;127(2):437-446
pubmed: 28145903
J Comp Neurol. 2017 Jun 1;525(8):1934-1961
pubmed: 28160289
Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2187-2192
pubmed: 28399269
Mitochondrion. 2017 Sep;36:77-84
pubmed: 28412540
Front Aging Neurosci. 2017 Apr 04;9:79
pubmed: 28420980
Front Neurosci. 2017 Apr 26;11:235
pubmed: 28491019
Front Neurol. 2017 May 04;8:162
pubmed: 28522986
Annu Rev Neurosci. 2017 Jul 25;40:539-556
pubmed: 28525301
Neurobiol Aging. 2018 Jan;61:146-168
pubmed: 29080498
Curr Sleep Med Rep. 2017 Sep;3(3):222-234
pubmed: 29177129
Neuron. 2018 Jan 3;97(1):251
pubmed: 29301102
Sleep Med Rev. 2018 Oct;41:101-112
pubmed: 29449121
Mov Disord. 2018 Aug;33(8):1315-1324
pubmed: 29737566
Sci Rep. 2018 May 17;8(1):7796
pubmed: 29773814
Exp Eye Res. 2018 Sep;174:93-97
pubmed: 29856984
J Biol Rhythms. 2018 Aug;33(4):441-445
pubmed: 29940798
Mov Disord. 2018 Oct;33(10):1601-1608
pubmed: 30145797
Acta Neuropathol Commun. 2018 Sep 10;6(1):90
pubmed: 30201049
J Comp Neurol. 2019 Jan 1;527(1):297-311
pubmed: 30311650
Mov Disord. 2018 Sep;33(9):1390-1406
pubmed: 30311977
Aging (Albany NY). 2018 Nov 13;10(11):3065-3066
pubmed: 30425185
Front Neurol. 2018 Nov 29;9:1019
pubmed: 30555403
Aging (Albany NY). 2018 Dec 26;11(1):15-17
pubmed: 30591618
Exp Eye Res. 2019 Mar;180:192-199
pubmed: 30605663
Front Cell Neurosci. 2019 Feb 27;13:59
pubmed: 30873007
Exp Eye Res. 1986 Apr;42(4):293-304
pubmed: 3709700
Neurosci Biobehav Rev. 1995 Spring;19(1):53-8
pubmed: 7770197
Vision Res. 1993 Dec;33(18):2589-609
pubmed: 8296455
Ophthalmic Res. 1995;27 Suppl 1:154-63
pubmed: 8577455
Neuroscience. 1996 Feb;70(4):951-61
pubmed: 8848176
Pharmacol Ther. 1996;71(3):253-312
pubmed: 8940745
J Comp Neurol. 1998 Jun 15;395(4):417-39
pubmed: 9619497
Neurosci Lett. 1998 Dec 24;258(3):167-70
pubmed: 9885957