Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
received:
31
01
2019
accepted:
01
06
2019
entrez:
3
7
2019
pubmed:
3
7
2019
medline:
26
9
2019
Statut:
epublish
Résumé
Multiple areas within the reticular activating system (RAS) can hasten awakening from sleep or light planes of anesthesia. However, stimulation in individual sites has shown limited recovery from deep global suppression of brain activity, such as coma. Here we identify a subset of RAS neurons within the anterior portion of nucleus gigantocellularis (aNGC) capable of producing a high degree of awakening represented by a broad high frequency cortical reactivation associated with organized movements and behavioral reactivity to the environment from two different models of deep pharmacologically-induced coma (PIC): isoflurane (1.25%-1.5%) and induced hypoglycemic coma. Activating aNGC neurons triggered awakening by recruiting cholinergic, noradrenergic, and glutamatergic arousal pathways. In summary, we identify an evolutionarily conserved population of RAS neurons, which broadly restore cerebral cortical activation and motor behavior in rodents through the coordinated activation of multiple arousal-promoting circuits.
Identifiants
pubmed: 31263107
doi: 10.1038/s41467-019-10797-7
pii: 10.1038/s41467-019-10797-7
pmc: PMC6603023
doi:
Substances chimiques
Anesthetics, Inhalation
0
Isoflurane
CYS9AKD70P
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2897Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM124023
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS094655
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : NS094655
Pays : International
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