Nomegestrol acetate/17beta-estradiol does not negatively alter the vascular resistance of clitoral arteries: a prospective, exploratory study.
Adult
Clitoris
/ blood supply
Contraceptives, Oral, Hormonal
/ therapeutic use
Estradiol
/ therapeutic use
Female
Humans
Italy
Linear Models
Megestrol
/ therapeutic use
Norpregnadienes
/ therapeutic use
Pilot Projects
Prospective Studies
Ultrasonography, Doppler, Color
Uterine Artery
/ diagnostic imaging
Vascular Resistance
Young Adult
Journal
International journal of impotence research
ISSN: 1476-5489
Titre abrégé: Int J Impot Res
Pays: England
ID NLM: 9007383
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
06
03
2019
accepted:
14
05
2019
revised:
18
04
2019
pubmed:
3
7
2019
medline:
1
12
2020
entrez:
3
7
2019
Statut:
ppublish
Résumé
The effect of nomegestrol acetate/estradiol (NOMAC/E2) on clitoral and uterine vascularization has never been evaluated. We aimed to investigate, in women consulting for contraceptive needs, the possible changes in clitoral and uterine arteries hemodynamic parameters after 6 months treatment with NOMAC/E2 as compared with other hormonal contraceptives (HCs). In this observational, prospective pilot study, ten women were enrolled. Color Doppler ultrasound was performed on the clitoral and uterine arteries at baseline and after 6 months treatment with NOMAC/E2 (n = 5) or other HCs (n = 5). NOMAC/E2 did not exert any significant effect on clitoral vascular resistance expressed by the pulsatility index (PI); conversely, treatment with other HCs significantly increased this parameter (p = 0.04). The change in clitoral PI between the two groups retained a statistically significant difference even after adjusting for age. In the NOMAC/E2 group, at follow-up, uterine artery PI and acceleration were significantly reduced (p = 0.04), whereas no significant differences were observed in the HCs group; however, the change in uterine artery parameters did not differ significantly between the two groups. NOMAC/E2, differently from other COCs, does not negatively alter the vascular resistance of clitoral arteries and appears as a good contraceptive choice to protect both cardiovascular and sexual health.
Identifiants
pubmed: 31263248
doi: 10.1038/s41443-019-0162-7
pii: 10.1038/s41443-019-0162-7
doi:
Substances chimiques
Contraceptives, Oral, Hormonal
0
Norpregnadienes
0
Estradiol
4TI98Z838E
nomegestrol acetate
83J78V5W05
Megestrol
EA6LD1M70M
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
239-247Références
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