Genome-wide association analysis uncovers variants for reproductive variation across dog breeds and links to domestication.
artificial selection
life history
pregnancy
prematurity
preterm birth
tradeoff
Journal
Evolution, medicine, and public health
ISSN: 2050-6201
Titre abrégé: Evol Med Public Health
Pays: England
ID NLM: 101616698
Informations de publication
Date de publication:
2019
2019
Historique:
received:
16
12
2018
accepted:
09
05
2019
entrez:
3
7
2019
pubmed:
3
7
2019
medline:
3
7
2019
Statut:
epublish
Résumé
The diversity of eutherian reproductive strategies has led to variation in many traits, such as number of offspring, age of reproductive maturity and gestation length. While reproductive trait variation has been extensively investigated and is well established in mammals, the genetic loci contributing to this variation remain largely unknown. The domestic dog, By matching our phenotypic data to genomic data from the Cornell Veterinary Biobank, we performed genome-wide association analyses for these four reproductive traits, using body mass and kinship among breeds as covariates. We identified 12 genome-wide significant associations between these traits and genetic loci, including variants near We hypothesize that the artificial selection that gave rise to dog breeds also influenced the observed variation in their reproductive traits. Overall, our work establishes the domestic dog as a system for studying the genetics of reproductive biology and disease. The genetic contributors to variation in mammalian reproductive traits remain largely unknown. We took advantage of the domestic dog, a powerful model system, to test for associations between genome-wide variants and four reproductive traits (cesarean section rate, litter size, stillbirth rate and gestation length) that vary extensively across breeds. We identified associations at a dozen loci, including ones previously associated with domestication-related traits, suggesting that selection on dog breeds also influenced their reproductive traits.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
The diversity of eutherian reproductive strategies has led to variation in many traits, such as number of offspring, age of reproductive maturity and gestation length. While reproductive trait variation has been extensively investigated and is well established in mammals, the genetic loci contributing to this variation remain largely unknown. The domestic dog,
METHODOLOGY
METHODS
By matching our phenotypic data to genomic data from the Cornell Veterinary Biobank, we performed genome-wide association analyses for these four reproductive traits, using body mass and kinship among breeds as covariates.
RESULTS
RESULTS
We identified 12 genome-wide significant associations between these traits and genetic loci, including variants near
CONCLUSIONS AND IMPLICATIONS
CONCLUSIONS
We hypothesize that the artificial selection that gave rise to dog breeds also influenced the observed variation in their reproductive traits. Overall, our work establishes the domestic dog as a system for studying the genetics of reproductive biology and disease.
LAY SUMMARY
BACKGROUND
The genetic contributors to variation in mammalian reproductive traits remain largely unknown. We took advantage of the domestic dog, a powerful model system, to test for associations between genome-wide variants and four reproductive traits (cesarean section rate, litter size, stillbirth rate and gestation length) that vary extensively across breeds. We identified associations at a dozen loci, including ones previously associated with domestication-related traits, suggesting that selection on dog breeds also influenced their reproductive traits.
Identifiants
pubmed: 31263560
doi: 10.1093/emph/eoz015
pii: eoz015
pmc: PMC6592264
doi:
Banques de données
Dryad
['10.5061/dryad.266k4']
Types de publication
Journal Article
Langues
eng
Pagination
93-103Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM127087
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM128596
Pays : United States
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