Serum biomarkers of delirium in the elderly: a narrative review.
Journal
Annals of intensive care
ISSN: 2110-5820
Titre abrégé: Ann Intensive Care
Pays: Germany
ID NLM: 101562873
Informations de publication
Date de publication:
01 Jul 2019
01 Jul 2019
Historique:
received:
06
06
2019
accepted:
20
06
2019
entrez:
3
7
2019
pubmed:
3
7
2019
medline:
3
7
2019
Statut:
epublish
Résumé
Delirium after surgery and in the intensive care unit (ICU) remains a challenge for patients, families, and caregivers. Over the years, many promising biomarkers have been investigated as potential instruments for risk stratification of delirium. This review aimed to identify and assess the clinical usefulness of candidate serum biomarkers associated with hospital delirium in patients aged 60 years and older. We performed a time-unlimited review of publications indexed in PubMed, Cochrane, Embase, and MEDLINE databases until June 2019 that evaluated baseline and/or longitudinal biomarker measurements in patients suffering from delirium at some point during their hospital stay. A total of 32 studies were included in this review reporting information on 7610 patients. Of these 32 studies, twenty-four studies reported data from surgical patients including four studies in ICU cohorts, five studies reported data from medical patients (1026 patients), and three studies reported data from a mixed cohort (1086 patients), including one study in an ICU cohort. Findings confirm restricted clinical usefulness to predict or diagnose delirium due to limited evidence on which biomarkers can be used and limited availability due to non-routine use.
Identifiants
pubmed: 31263968
doi: 10.1186/s13613-019-0548-1
pii: 10.1186/s13613-019-0548-1
pmc: PMC6603109
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
76Références
J Am Geriatr Soc. 2000 Jun;48(6):618-24
pubmed: 10855596
Psychol Med. 2000 Jul;30(4):921-9
pubmed: 11037100
Lancet. 2001 Apr 21;357(9264):1264-5
pubmed: 11418154
Am J Respir Crit Care Med. 2002 Nov 15;166(10):1338-44
pubmed: 12421743
J Am Geriatr Soc. 2003 Nov;51(11):1539-46
pubmed: 14687382
Gerontology. 2004 Jul-Aug;50(4):216-22
pubmed: 15258426
J Card Surg. 2005 Nov-Dec;20(6):560-7
pubmed: 16309412
N Engl J Med. 2006 Mar 16;354(11):1157-65
pubmed: 16540616
J Gerontol A Biol Sci Med Sci. 2006 Dec;61(12):1277-80
pubmed: 17234820
Arch Intern Med. 2008 Jan 14;168(1):27-32
pubmed: 18195192
Hist Psychiatry. 2007 Dec;18(72 Pt 4):459-69
pubmed: 18590023
J Am Geriatr Soc. 2008 Sep;56(9):1704-9
pubmed: 18691278
J Gerontol A Biol Sci Med Sci. 2008 Jul;63(7):764-72
pubmed: 18693233
Crit Care Clin. 2008 Oct;24(4):657-722, vii
pubmed: 18929939
J Cardiothorac Vasc Anesth. 2009 Oct;23(5):651-7
pubmed: 19231245
Ann Thorac Surg. 2009 Jul;88(1):349-50; author reply 350-1
pubmed: 19559271
Psychosomatics. 2009 May-Jun;50(3):234-8
pubmed: 19567762
Spine (Phila Pa 1976). 2010 Aug 15;35(18):1729-32
pubmed: 20150830
Psychosomatics. 2010 Sep-Oct;51(5):409-18
pubmed: 20833940
Rejuvenation Res. 2011 Aug;14(4):425-8
pubmed: 21851175
Ann Thorac Surg. 2012 Mar;93(3):705-11
pubmed: 21992939
J Am Geriatr Soc. 2011 Nov;59 Suppl 2:S256-61
pubmed: 22091570
Crit Care. 2011;15(6):R297
pubmed: 22206727
Psychiatry Investig. 2011 Dec;8(4):340-7
pubmed: 22216044
J Am Geriatr Soc. 2012 Apr;60(4):669-75
pubmed: 22316182
Eur J Cardiothorac Surg. 2012 Mar;41(3):544-9
pubmed: 22345177
Intensive Care Med. 2012 Dec;38(12):1965-73
pubmed: 22903241
Neuropsychiatr Dis Treat. 2013;9:659-66
pubmed: 23717044
Langenbecks Arch Surg. 2014 Jan;399(1):77-84
pubmed: 24337734
Int Psychogeriatr. 2014 May;26(5):717-24
pubmed: 24460925
Peptides. 2014 Jul;57:31-5
pubmed: 24787655
Crit Care. 2014 May 23;18(3):R106
pubmed: 24886875
Front Endocrinol (Lausanne). 2014 Oct 17;5:173
pubmed: 25368603
Crit Care. 2015 Apr 21;19:186
pubmed: 25896893
Front Aging Neurosci. 2015 Jun 09;7:112
pubmed: 26106326
Lancet Neurol. 2015 Aug;14(8):823-832
pubmed: 26139023
Braz J Psychiatry. 2015 Jul-Sep;37(3):197-202
pubmed: 26376051
J Cardiothorac Vasc Anesth. 2015 Dec;29(6):1677-87
pubmed: 26456271
J Crit Care. 2016 Jun;33:56-61
pubmed: 26852394
Clin Chim Acta. 2016 Apr 1;455:149-53
pubmed: 26874041
J Int Med Res. 2016 Apr;44(2):317-27
pubmed: 26920926
Crit Care Med. 2016 Sep;44(9):e809-17
pubmed: 27088157
Psychiatry Investig. 2016 May;13(3):327-32
pubmed: 27247600
J Pain Symptom Manage. 2016 Oct;52(4):525-532
pubmed: 27401519
Ann Intensive Care. 2016 Dec;6(1):104
pubmed: 27797086
Neuropsychiatr Dis Treat. 2016 Oct 27;12:2789-2795
pubmed: 27822051
Clin Chim Acta. 2017 Mar;466:93-97
pubmed: 28093200
Ann Intensive Care. 2017 Dec;7(1):34
pubmed: 28332157
J Am Geriatr Soc. 2017 Aug;65(8):e109-e116
pubmed: 28555781
Clin Interv Aging. 2017 Jul 14;12:1115-1121
pubmed: 28769556
Vasc Med. 2017 Oct;22(5):387-397
pubmed: 28784053
Ann Intensive Care. 2017 Sep 2;7(1):88
pubmed: 28866754
J Crit Care. 2018 Apr;44:45-50
pubmed: 29055835
J Geriatr Psychiatry Neurol. 2017 Nov;30(6):337-345
pubmed: 29061098
J Neuroinflammation. 2017 Nov 14;14(1):221
pubmed: 29137628
Gerontol Geriatr Med. 2017 Nov 13;3:2333721417739188
pubmed: 29164173
Trials. 2018 Feb 26;19(1):142
pubmed: 29482596
Ann Intensive Care. 2018 Mar 1;8(1):33
pubmed: 29492696
Intensive Care Med. 2018 Mar;44(3):345-355
pubmed: 29523900
J Gerontol A Biol Sci Med Sci. 2019 Jan 16;74(2):261-268
pubmed: 29529166
Crit Care Med. 2018 Sep;46(9):e825-e873
pubmed: 30113379
Ann Intensive Care. 2018 Sep 20;8(1):92
pubmed: 30238227
Clin Interv Aging. 2018 Oct 24;13:2127-2134
pubmed: 30425466
J Cancer Res Ther. 2018 Oct-Dec;14(6):1234-1238
pubmed: 30488836
Clin Interv Aging. 2019 Feb 07;14:271-281
pubmed: 30799917
Int J Geriatr Psychiatry. 2019 May 6;:null
pubmed: 31058343
Lancet. 1981 Sep 26;2(8248):651-3
pubmed: 6116042
J Gen Intern Med. 1998 Mar;13(3):204-12
pubmed: 9541379