Obsessive-Compulsive Symptoms in Schizophrenia: an Up-To-Date Review of Literature.
Antipsychotics
Obsessive-compulsive disorder
Obsessive-compulsive symptoms
Schizo-obsessive disorder
Schizophrenia
Ultra-high risk (UHR) of psychosis
Journal
Current psychiatry reports
ISSN: 1535-1645
Titre abrégé: Curr Psychiatry Rep
Pays: United States
ID NLM: 100888960
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
entrez:
3
7
2019
pubmed:
3
7
2019
medline:
4
4
2020
Statut:
epublish
Résumé
This review will aim to summarize the current body of epidemiological, clinical and therapeutic knowledge concerning specific co-occurrence of obsessive-compulsive symptoms (OCSs) and schizophrenia spectrum disorder. Almost 30% of the patients with schizophrenia display OCS, and three main contexts of emergence are identified: prodromal symptoms of schizophrenia, co-occurrence of OCS and schizophrenia and antipsychotics-induced OCS. Recent clinical studies show that patients with SZ and OCS have more severe psychotic and depressive symptoms, higher suicidality and lower social functioning. A recent cognitive investigation found that OCS and delusions share specific metacognitive profiles, particularly through a heightened need to control thoughts. Finally, a recent cross-sectional study of clozapine-induced OCS found a dose-response relationship between clozapine and OCS. OCS appeared reliably as linked to poorer outcomes among patients with schizophrenia. However, the specific clinical value of OCS among other prodromal symptoms of schizophrenia remains unknown.
Identifiants
pubmed: 31263973
doi: 10.1007/s11920-019-1051-y
pii: 10.1007/s11920-019-1051-y
doi:
Substances chimiques
Antipsychotic Agents
0
Clozapine
J60AR2IKIC
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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