WOMEN IN REPRODUCTIVE SCIENCE: To be or not to be a testis.


Journal

Reproduction (Cambridge, England)
ISSN: 1741-7899
Titre abrégé: Reproduction
Pays: England
ID NLM: 100966036

Informations de publication

Date de publication:
12 2019
Historique:
received: 29 03 2019
accepted: 25 06 2019
pubmed: 3 7 2019
medline: 4 8 2020
entrez: 3 7 2019
Statut: ppublish

Résumé

Work that established the testis as the driver of male development, and the Y chromosome as the bearer of the male-determining gene, established a working model, and set the stage for the molecular age of mammalian sex determination. The discovery and characterization of Sry/SRY at the top of the hierarchy in mammals launched the field in two major directions. The first was to identify the downstream transcription factors and other molecular players that drive the bifurcation of Sertoli and granulosa cell differentiation. The second major direction was to understand organogenesis of the early bipotential gonad, and how divergence of its two distinct morphogenetic pathways (testis and ovary) is regulated at the cellular level. This review will summarize the early discoveries soon after Sry was identified and focus on my study of the gonad as a model of organogenesis.

Identifiants

pubmed: 31265995
doi: 10.1530/REP-19-0151
pii: REP-19-0151.R1
pmc: PMC9945370
mid: NIHMS1533826
doi:
pii:

Types de publication

Biography Historical Article Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

F101-F111

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD039963
Pays : United States
Organisme : NICHD NIH HHS
ID : R37 HD039963
Pays : United States

Sujets (noms de personnes)

{'last_name': 'Capel', 'fore_name': 'Blanche', 'initials': 'B'}

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Auteurs

Blanche Capel (B)

Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA.

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