Telomeres and Longevity: A Cause or an Effect?

Aging / genetics Animals Female Longevity Male Mice Mole Rats Organ Specificity Spalax Species Specificity Telomere / genetics Telomere Shortening
age blind mole-rats (Spalax) long-lived longevity naked mole-rats telomere length telomeres

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
01 Jul 2019
Historique:
received: 02 05 2019
revised: 25 06 2019
accepted: 29 06 2019
entrez: 4 7 2019
pubmed: 4 7 2019
medline: 18 12 2019
Statut: epublish

Résumé

Telomere dynamics have been found to be better predictors of survival and mortality than chronological age. Telomeres, the caps that protect the end of linear chromosomes, are known to shorten with age, inducing cell senescence and aging. Furthermore, differences in age-related telomere attrition were established between short-lived and long-lived organisms. However, whether telomere length is a "biological thermometer" that reflects the biological state at a certain point in life or a biomarker that can influence biological conditions, delay senescence and promote longevity is still an ongoing debate. We cross-sectionally tested telomere length in different tissues of two long-lived (naked mole-rat and

Identifiants

DOI: 10.3390/ijms20133233 PMID: 31266154 PMC: PMC6651551
pubmed: 31266154
pii: ijms20133233
doi: 10.3390/ijms20133233
pmc: PMC6651551
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Israel Science Foundation
ID : 193/16

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Auteurs

Huda Adwan Shekhidem (H)

Department of Human Biology, University of Haifa, Haifa 3498838, Israel.

Lital Sharvit (L)

Department of Human Biology, University of Haifa, Haifa 3498838, Israel.
ORCID: 0000-0002-2577-1907

Eva Leman (E)

Institute of Evolution and Department of Evolutionary and Environmental Biology, University of Haifa, Haifa 3498838, Israel.

Irena Manov (I)

Institute of Evolution and Department of Evolutionary and Environmental Biology, University of Haifa, Haifa 3498838, Israel.

Asael Roichman (A)

Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel.
ORCID: 0000-0001-9538-0103

Susanne Holtze (S)

Leibniz Institute for Zoo and Wildlife Research, D-10315 Berlin, Germany.

Derek M Huffman (D)

Departments of Molecular Pharmacology, Medicine, and the Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Haim Y Cohen (H)

Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel.

Thomas Bernd Hildebrandt (T)

Leibniz Institute for Zoo and Wildlife Research, D-10315 Berlin, Germany.
Freie Universität Berlin, D-14195 Berlin, Germany.

Imad Shams (I)

Institute of Evolution and Department of Evolutionary and Environmental Biology, University of Haifa, Haifa 3498838, Israel.

Gil Atzmon (G)

Department of Human Biology, University of Haifa, Haifa 3498838, Israel. gatzmon@univ.haifa.ac.il.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Telomeres and Longevity: A Cause or an Effect?
questionsmedicales.fr › Eucaryotes › Animaux › Telomeres and Longevity: A Cause or an Effect?
questionsmedicales.fr › Phénomènes physiologiques › Longévité › Telomeres and Longevity: A Cause or an Effect?
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Telomeres and Longevity: A Cause or an Effect?
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Rats taupes › Telomeres and Longevity: A Cause or an Effect?
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › Telomeres and Longevity: A Cause or an Effect?
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Rats taupes › Spalax › Telomeres and Longevity: A Cause or an Effect?
questionsmedicales.fr › Phénomènes biologiques › Spécificité d'espèce › Telomeres and Longevity: A Cause or an Effect?
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Télomère › Telomeres and Longevity: A Cause or an Effect?
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Raccourcissement des télomères › Telomeres and Longevity: A Cause or an Effect?