Hypertension Exacerbates Cerebrovascular Oxidative Stress Induced by Mild Traumatic Brain Injury: Protective Effects of the Mitochondria-Targeted Antioxidative Peptide SS-31.
Animals
Antioxidants
/ administration & dosage
Brain Concussion
/ complications
Drug Delivery Systems
/ methods
Hypertension
/ complications
Male
Mitochondria
/ drug effects
Neuroprotective Agents
/ administration & dosage
Oligopeptides
/ administration & dosage
Oxidative Stress
/ drug effects
Rats
Rats, Inbred SHR
Rats, Wistar
MCA
brain trauma
free radicals
hypertension
mitochondrion
Journal
Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
pubmed:
4
7
2019
medline:
11
11
2020
entrez:
4
7
2019
Statut:
ppublish
Résumé
Traumatic brain injury (TBI) induces cerebrovascular oxidative stress, which is associated with neurovascular uncoupling, autoregulatory dysfunction, and persisting cognitive decline in both pre-clinical models and patients. However, single mild TBI (mTBI), the most frequent form of brain trauma, increases cerebral generation of reactive oxygen species (ROS) only transiently. We hypothesized that comorbid conditions might exacerbate long-term ROS generation in cerebral arteries after mTBI. Because hypertension is the most important cerebrovascular risk factor in populations prone to mild brain trauma, we induced mTBI in normotensive and spontaneously hypertensive rats (SHR) and assessed changes in cytoplasmic and mitochondrial superoxide (O
Identifiants
pubmed: 31266393
doi: 10.1089/neu.2019.6439
pmc: PMC6857460
doi:
Substances chimiques
Antioxidants
0
Neuroprotective Agents
0
Oligopeptides
0
arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3309-3315Subventions
Organisme : NIA NIH HHS
ID : R01 AG047879
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055395
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS056218
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100782
Pays : United States
Références
J Neurotrauma. 2017 Jul 15;34(14):2315-2319
pubmed: 28249552
Free Radic Biol Med. 2018 Mar;117:66-75
pubmed: 29391196
J Neurosci. 2002 Jan 15;22(2):446-54
pubmed: 11784789
Res Gerontol Nurs. 2012 Jan;5(1):17-24
pubmed: 22165997
J Cereb Blood Flow Metab. 2018 Oct;38(10):1818-1827
pubmed: 29083257
Circ Res. 2012 Apr 13;110(8):1109-24
pubmed: 22499901
Free Radic Res. 2007 Oct;41(10):1151-8
pubmed: 17886037
Circ Res. 2012 Apr 27;110(9):1159-61
pubmed: 22539753
Am J Physiol Heart Circ Physiol. 2013 Nov 15;305(10):H1417-27
pubmed: 24043248
J Neurotrauma. 2018 Jan 12;:
pubmed: 29179622
J Neurosurg. 1974 Nov;41(5):531-41
pubmed: 4418221
J Head Trauma Rehabil. 2018 Jan/Feb;33(1):15-24
pubmed: 28060201
Redox Biol. 2018 Jun;16:285-293
pubmed: 29571125
J Neurotrauma. 2013 May 1;30(9):789-96
pubmed: 22928502
Free Radic Biol Med. 2013 Jul;60:282-91
pubmed: 23466554
Brain Res. 2007 Feb 2;1131(1):129-37
pubmed: 17161389
J Neuroinflammation. 2013 Dec 17;10:155
pubmed: 24344836
Free Radic Biol Med. 2011 Oct 1;51(7):1289-301
pubmed: 21777669
Mol Chem Neuropathol. 1997 Jan-Feb;30(1-2):125-37
pubmed: 9138424
J Biol Chem. 2004 Aug 13;279(33):34682-90
pubmed: 15178689
Theranostics. 2018 Sep 09;8(17):4824-4836
pubmed: 30279740
J Neurosci. 2005 Feb 16;25(7):1769-77
pubmed: 15716413
Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H1882-94
pubmed: 18757483
J Neurochem. 2004 Aug;90(3):758-64
pubmed: 15255955
Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H299-308
pubmed: 24322615
J Am Coll Cardiol. 2011 Jun 28;58(1):73-82
pubmed: 21620606
Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1118-H1131
pubmed: 27614225
Transl Stroke Res. 2016 Aug;7(4):248-60
pubmed: 27026092
Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):9056-61
pubmed: 15941833
Cell Transplant. 2017 Jul;26(7):1131-1155
pubmed: 28933213
J Am Soc Hypertens. 2011 May-Jun;5(3):137-53
pubmed: 21419746
Nat Neurosci. 2009 Jul;12(7):857-63
pubmed: 19503084
Aging Cell. 2018 Apr;17(2):
pubmed: 29405550
J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1355-9
pubmed: 25631392