A Novel FGFR3 Splice Variant Preferentially Expressed in African American Prostate Cancer Drives Aggressive Phenotypes and Docetaxel Resistance.


Journal

Molecular cancer research : MCR
ISSN: 1557-3125
Titre abrégé: Mol Cancer Res
Pays: United States
ID NLM: 101150042

Informations de publication

Date de publication:
10 2019
Historique:
received: 18 04 2019
revised: 19 06 2019
accepted: 21 06 2019
pubmed: 4 7 2019
medline: 17 7 2020
entrez: 4 7 2019
Statut: ppublish

Résumé

Alternative splicing (AS) has been shown to participate in prostate cancer development and progression; however, a link between AS and prostate cancer health disparities has been largely unexplored. Here we report on the cloning of a novel splice variant of

Identifiants

pubmed: 31266816
pii: 1541-7786.MCR-19-0415
doi: 10.1158/1541-7786.MCR-19-0415
pmc: PMC6886680
mid: NIHMS1533145
doi:

Substances chimiques

Docetaxel 15H5577CQD
FGFR3 protein, human EC 2.7.10.1
Receptor, Fibroblast Growth Factor, Type 3 EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

2115-2125

Subventions

Organisme : NCI NIH HHS
ID : R01 CA204806
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD084633
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103457
Pays : United States
Organisme : NIEHS NIH HHS
ID : K01 ES025434
Pays : United States
Organisme : NIGMS NIH HHS
ID : SC1 GM127256
Pays : United States

Informations de copyright

©2019 American Association for Cancer Research.

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Auteurs

Jacqueline Olender (J)

Department of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, GW Cancer Center, Washington, D. C.

Bi-Dar Wang (BD)

Department of Pharmaceutical Sciences, School of Pharmacy and Health Professions, University of Maryland Eastern Shore, Princess Anne, Maryland.

Travers Ching (T)

Cancer Epidemiology Program, University of Hawaii, Honolulu, Hawaii.

Lana X Garmire (LX)

Department of Computational Medicine and Bioinformatics, School of Medicine, University of Michigan, Ann Arbor, Michigan.

Kaitlin Garofano (K)

Department of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, GW Cancer Center, Washington, D. C.

Youngmi Ji (Y)

Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland.

Tessa Knox (T)

Department of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, GW Cancer Center, Washington, D. C.

Patricia Latham (P)

Department of Pathology, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia.

Kenneth Nguyen (K)

Department of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, GW Cancer Center, Washington, D. C.

Johng Rhim (J)

Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of Health Sciences, Bethesda, Maryland.

Norman H Lee (NH)

Department of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, GW Cancer Center, Washington, D. C. nhlee@gwu.edu.

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Classifications MeSH