Infiltrating and peripheral immune cell analysis in advanced gastric cancer according to the Lauren classification and its prognostic significance.
Advanced gastric adenocarcinoma
Biomarker
CD8+ T lymphocytes
Natural killer cells
Regulatory T cells
Journal
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
ISSN: 1436-3305
Titre abrégé: Gastric Cancer
Pays: Japan
ID NLM: 100886238
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
20
02
2019
accepted:
25
06
2019
pubmed:
4
7
2019
medline:
30
5
2020
entrez:
4
7
2019
Statut:
ppublish
Résumé
The correlation between immune cells and the Lauren classification subtypes and their prognostic impact in advanced gastric cancer (AGC) are unknown. Circulating natural killer (NK) cells, CD4 Circulating NK and Treg proportions were significantly lower in patients with diffuse/mixed-type AGC (n = 27) than those with intestinal type (n = 40; median 6.3% vs 11.5%; p = 0.02 and median 3.3% vs 5.2%; p = 0.03, respectively). Proportions of circulating MDSC, CD4 Diffuse/mixed-type AGC has lower rates of CD8
Sections du résumé
BACKGROUND
The correlation between immune cells and the Lauren classification subtypes and their prognostic impact in advanced gastric cancer (AGC) are unknown.
METHODS
Circulating natural killer (NK) cells, CD4
RESULTS
Circulating NK and Treg proportions were significantly lower in patients with diffuse/mixed-type AGC (n = 27) than those with intestinal type (n = 40; median 6.3% vs 11.5%; p = 0.02 and median 3.3% vs 5.2%; p = 0.03, respectively). Proportions of circulating MDSC, CD4
CONCLUSION
Diffuse/mixed-type AGC has lower rates of CD8
Identifiants
pubmed: 31267360
doi: 10.1007/s10120-019-00983-3
pii: 10.1007/s10120-019-00983-3
doi:
Types de publication
Clinical Trial, Phase II
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-81Références
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