Vagal mechanisms as neuromodulatory targets for the treatment of metabolic disease.
anti-inflammatory pathways
diabetes
electrical stimulation
genetically guided
gut-brain communication
neuromodulation
obesity
vagotomy
Journal
Annals of the New York Academy of Sciences
ISSN: 1749-6632
Titre abrégé: Ann N Y Acad Sci
Pays: United States
ID NLM: 7506858
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
18
03
2019
revised:
23
05
2019
accepted:
05
06
2019
pubmed:
4
7
2019
medline:
6
5
2020
entrez:
4
7
2019
Statut:
ppublish
Résumé
With few effective treatments available, the global rise of metabolic diseases, including obesity, type 2 diabetes mellitus, and cardiovascular disease, seems unstoppable. Likely caused by an obesogenic environment interacting with genetic susceptibility, the pathophysiology of obesity and metabolic diseases is highly complex and involves crosstalk between many organs and systems, including the brain. The vagus nerve is in a key position to bidirectionally link several peripheral metabolic organs with the brain and is increasingly targeted for neuromodulation therapy to treat metabolic disease. Here, we review the basics of vagal functional anatomy and its implications for vagal neuromodulation therapies. We find that most existing vagal neuromodulation techniques either ignore or misinterpret the rich functional specificity of both vagal efferents and afferents as demonstrated by a large body of literature. This lack of specificity of manipulating vagal fibers is likely the reason for the relatively poor beneficial long-term effects of such therapies. For these therapies to become more effective, rigorous validation of all physiological endpoints and optimization of stimulation parameters as well as electrode placements will be necessary. However, given the large number of function-specific fibers in any vagal branch, genetically guided neuromodulation techniques are more likely to succeed.
Identifiants
pubmed: 31268181
doi: 10.1111/nyas.14182
pmc: PMC6810744
mid: NIHMS1034444
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
42-55Subventions
Organisme : NIH HHS
ID : OT2 OD023864
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK047348
Pays : United States
Informations de copyright
© 2019 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals, Inc. on behalf of The New York Academy of Sciences.
Références
Eur Heart J. 2012 May;33(10):1279-89
pubmed: 21825308
Br J Pharmacol. 2012 Jul;166(5):1537-58
pubmed: 22432806
Science. 2012 May 4;336(6081):604-8
pubmed: 22556257
Nat Neurosci. 2017 May;20(5):700-707
pubmed: 28288124
J Auton Nerv Syst. 1986 Jan;15(1):55-69
pubmed: 3512681
Diabetologia. 1980 Jan;18(1):73-8
pubmed: 6988269
Cell. 2016 Jun 30;166(1):209-21
pubmed: 27238020
Acta Anat (Basel). 1983;115(3):266-71
pubmed: 6845965
Anat Embryol (Berl). 1997 Feb;195(2):183-91
pubmed: 9045988
Nutrition. 2015 Nov-Dec;31(11-12):1416-22
pubmed: 26429664
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):11008-13
pubmed: 18669662
J Comp Neurol. 2001 Oct 8;439(1):1-18
pubmed: 11579378
J Comp Neurol. 1975 May 1;161(1):103-13
pubmed: 48519
Tissue Cell. 2016 Dec;48(6):567-576
pubmed: 27823763
Cancer. 2009 Aug 1;115(15):3379-91
pubmed: 19484787
Exp Physiol. 2012 Nov;97(11):1180-5
pubmed: 22247284
Physiol Behav. 2011 Nov 30;105(1):106-19
pubmed: 21315095
Auton Neurosci. 2014 May;182:42-54
pubmed: 24530113
J Neural Eng. 2017 Aug;14(4):046022
pubmed: 28361793
J Comp Neurol. 2000 Jun 5;421(3):302-24
pubmed: 10813789
J Comp Neurol. 1995 Mar 6;353(2):161-78
pubmed: 7538152
Am J Physiol Regul Integr Comp Physiol. 2006 Nov;291(5):R1243-55
pubmed: 16809481
J Auton Nerv Syst. 1987 Oct;20(3):243-55
pubmed: 3693803
Diabetes. 2011 Nov;60(11):2691-700
pubmed: 21896928
Regul Pept. 2008 Aug 7;149(1-3):15-25
pubmed: 18482776
Hepatogastroenterology. 1999 Jun;46 Suppl 2:1414-7
pubmed: 10431702
PLoS One. 2013 Jun 26;8(6):e67198
pubmed: 23840624
Cancer Discov. 2018 Nov;8(11):1458-1473
pubmed: 30185628
J Exp Med. 2006 Jul 10;203(7):1623-8
pubmed: 16785311
Histochem J. 1971 Jan;3(1):47-53
pubmed: 5110264
Nat Immunol. 2005 Aug;6(8):844-51
pubmed: 16025117
J Auton Nerv Syst. 1993 Feb;42(2):153-69
pubmed: 8450174
Microsc Res Tech. 1996 Sep 1;35(1):80-6
pubmed: 8873061
Oncotarget. 2017 Apr 4;8(14):22501-22512
pubmed: 28160574
Brain Res. 2013 Nov 6;1537:132-42
pubmed: 24028856
Anat Embryol (Berl). 1995 Mar;191(3):203-12
pubmed: 7771683
BMC Complement Altern Med. 2014 Jun 26;14:203
pubmed: 24968966
J Comp Neurol. 2004 Apr 12;471(4):462-81
pubmed: 15022264
Am J Physiol. 1973 Aug;225(2):481-6
pubmed: 4722412
Cell Tissue Res. 1998 Sep;293(3):395-405
pubmed: 9716729
Science. 1994 Jul 1;265(5168):121-2
pubmed: 8016646
J Comp Neurol. 1998 Dec 7;402(1):93-110
pubmed: 9831048
J Neural Eng. 2018 Jun;15(3):036018
pubmed: 29219123
Obes Surg. 2017 Jan;27(1):169-176
pubmed: 27506803
Obes Surg. 2015 Oct;25(10):1779-87
pubmed: 25771794
Obes Surg. 2015 Jan;25(1):174-9
pubmed: 25398551
J Comp Neurol. 1996 Jun 17;370(1):61-70
pubmed: 8797157
Neurology. 2002 Aug 13;59(3):463-4
pubmed: 12177391
Brain Res Brain Res Rev. 1989 Jan-Mar;14(1):53-77
pubmed: 2470452
J Neurosci. 2008 May 7;28(19):4957-66
pubmed: 18463249
Am J Physiol. 1990 Jan;258(1 Pt 2):R160-8
pubmed: 1967914
Diabetes. 2014 Mar;63(3):892-9
pubmed: 24270985
Cell Rep. 2016 Mar 15;14(10):2362-74
pubmed: 26947072
Diabetologia. 2018 Jan;61(1):158-167
pubmed: 28864913
Endocrinology. 2009 Oct;150(10):4502-11
pubmed: 19574396
Auton Neurosci. 2006 Apr 30;125(1-2):76-80
pubmed: 16473562
Am J Physiol. 1991 Jan;260(1 Pt 2):R200-7
pubmed: 1992820
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3078-83
pubmed: 26929329
Obes Surg. 2016 May;26(5):983-9
pubmed: 27048437
Am J Physiol. 1999 Nov;277(5):E958-64
pubmed: 10567025
Neurogastroenterol Motil. 2007 Jan;19(1 Suppl):1-19
pubmed: 17280582
J Natl Cancer Inst. 2010 Jan 20;102(2):107-18
pubmed: 20068194
J Auton Nerv Syst. 1989 Dec 30;29(1):13-8
pubmed: 2483726
Am J Physiol Regul Integr Comp Physiol. 2005 Aug;289(2):R456-R462
pubmed: 15831770
Neuroimmunomodulation. 1997 Sep-Dec;4(5-6):266-70
pubmed: 9650820
Science. 2018 Sep 21;361(6408):
pubmed: 30237325
Anat Rec. 2001 Jan 1;262(1):29-40
pubmed: 11146426
Anat Rec (Hoboken). 2016 Sep;299(9):1184-91
pubmed: 27342906
Int J Obes (Lond). 2007 Nov;31(11):1756-9
pubmed: 17563762
Lancet. 1978 Feb 11;1(8059):307-8
pubmed: 75340
Arthritis Res Ther. 2015 Mar 31;17:87
pubmed: 25889979
Anat Rec A Discov Mol Cell Evol Biol. 2004 Sep;280(1):827-35
pubmed: 15382018
J Clin Invest. 2002 Nov;110(9):1243-50
pubmed: 12417562
Histochemistry. 1975 Jul 16;44(1):23-30
pubmed: 1181337
J Hepatol. 2015 Apr;62(4):913-20
pubmed: 25433161
Gut. 2014 Jun;63(6):938-48
pubmed: 23929694
J Comp Neurol. 2012 Dec 1;520(17):3933-48
pubmed: 22592759
Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8284-9
pubmed: 27382171
Auton Neurosci. 2000 Dec 20;85(1-3):1-17
pubmed: 11189015
J Comp Neurol. 2011 Mar 1;519(4):644-60
pubmed: 21246548
Nat Rev Endocrinol. 2012 Dec;8(12):743-54
pubmed: 23169440
Curr Behav Neurosci Rep. 2014 Jun;1(2):64-73
pubmed: 24834378
Biomed Tech (Berl). 2008 Jun;53(3):104-11
pubmed: 18601618
Auton Neurosci. 2014 May;182:65-9
pubmed: 24411268
Brain Res. 1991 Jul 12;553(2):336-41
pubmed: 1718546
Cell. 2018 Oct 18;175(3):665-678.e23
pubmed: 30245012
J Comp Neurol. 1990 Nov 1;301(1):65-79
pubmed: 1706359
J Pediatr Surg. 2016 Jan;51(1):67-71
pubmed: 26526207
Brain Res. 1984 Feb 6;292(2):199-205
pubmed: 6692153
Munch Med Wochenschr. 1967 Aug 25;109(34):1763-9
pubmed: 5631871
Am J Physiol Regul Integr Comp Physiol. 2006 Nov;291(5):R1240-2
pubmed: 16857888
Brain Behav Immun. 2018 Oct;73:441-449
pubmed: 29883598
J Comp Neurol. 1992 May 8;319(2):261-76
pubmed: 1522247
PLoS One. 2013 Oct 23;8(10):e77221
pubmed: 24194874
Nat Med. 2005 Mar;11(3):320-7
pubmed: 15735652
Cancer Cell. 2017 Jan 9;31(1):21-34
pubmed: 27989802
Physiol Rev. 1985 Apr;65(2):211-37
pubmed: 2858893
Nature. 2003 Jan 23;421(6921):384-8
pubmed: 12508119
Prog Neurobiol. 1989;33(2):135-47
pubmed: 2678269
J Auton Nerv Syst. 1983 Feb;7(2):97-110
pubmed: 6348142
Neurosci Res. 2008 Dec;62(4):262-9
pubmed: 18940208
Appetite. 2007 Mar;48(2):145-53
pubmed: 17081655
Brain Stimul. 2013 Sep;6(5):788-97
pubmed: 23485649
Cancer Cell. 2018 Jan 8;33(1):75-90.e7
pubmed: 29249692
Neurosci Lett. 1996 May 31;210(2):115-8
pubmed: 8783286
JAMA. 2014 Sep 3;312(9):915-22
pubmed: 25182100
Anat Embryol (Berl). 1992 Oct;186(5):431-42
pubmed: 1280009
Obes Surg. 2006 Jun;16(6):762-9
pubmed: 16756739
Curr Opin Clin Nutr Metab Care. 2011 Sep;14(5):477-82
pubmed: 21832903
Diabetes. 2016 Sep;65(9):2711-23
pubmed: 27207534
Sci Transl Med. 2014 Aug 20;6(250):250ra115
pubmed: 25143365
Nature. 2000 May 25;405(6785):458-62
pubmed: 10839541
Rev Endocr Metab Disord. 2016 Mar;17(1):73-80
pubmed: 27106829
Histochemistry. 1994 Nov;102(5):353-64
pubmed: 7532638
Nat Med. 2015 Jan;21(1):92-98
pubmed: 25501906
J Neural Transm (Vienna). 2007;114(11):1485-93
pubmed: 17564758
Am J Physiol. 1975 Jun;228(6):1787-93
pubmed: 1155608