Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPARα/PPARγ Agonist Activity and Anti-inflammatory Effect.

Anti-Inflammatory Agents / chemistry Benzopyrans / chemistry Humans Molecular Structure PPAR alpha / agonists PPAR gamma / agonists Prenylation Structure-Activity Relationship

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
26 07 2019
Historique:
pubmed: 4 7 2019
medline: 22 10 2020
entrez: 4 7 2019
Statut: ppublish

Résumé

Dual peroxisome proliferator-activated receptor-α/γ (PPARα/γ) agonists regulate both lipid and glucose homeostasis under different metabolic conditions and can exert anti-inflammatory activity. We investigated the potential dual PPARα/γ agonism of prenylated benzopyrans polycerasoidol (

Identifiants

DOI: 10.1021/acs.jnatprod.9b00003 PMID: 31268307
pubmed: 31268307
doi: 10.1021/acs.jnatprod.9b00003
doi:

Substances chimiques

Anti-Inflammatory Agents 0
Benzopyrans 0
PPAR alpha 0
PPAR gamma 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1802-1812

Auteurs

Almudena Bermejo (A)

Department of Pharmacology , University of Valencia , 46113 Valencia Spain.
Center of Citriculture and Vegetal Production , IVIA , Moncada, 46100 Valencia , Spain.

Aida Collado (A)

Department of Pharmacology , University of Valencia , 46113 Valencia Spain.

Isabel Barrachina (I)

Department of Pharmacology , University of Valencia , 46113 Valencia Spain.

Patrice Marqués (P)

Department of Pharmacology , University of Valencia , 46113 Valencia Spain.
Institute of Health Research-INCLIVA , University Clinic Hospital of Valencia , 46010 Valencia , Spain.

Noureddine El Aouad (N)

Department of Pharmacology , University of Valencia , 46113 Valencia Spain.

Xavier Franck (X)

UMR CNRS 6014/FR 3038, COBRA, Université de Rouen , Mont-Saint-Aignan 76821 , France.
ORCID: 0000-0002-5615-7504

Francisco Garibotto (F)

Facultad de Química, Bioquímica y Farmacia , Universidad Nacional de San Luis-IMIBIO-SL-CONICET , Chacabuco 915 , San Luis , Argentina.

Catherine Dacquet (C)

Départament des Sciences Expérimentales , Institut de Recherches Servier , Suresnes 92150 , France.

Daniel H Caignard (DH)

Départament des Sciences Expérimentales , Institut de Recherches Servier , Suresnes 92150 , France.

Fernando D Suvire (FD)

Facultad de Química, Bioquímica y Farmacia , Universidad Nacional de San Luis-IMIBIO-SL-CONICET , Chacabuco 915 , San Luis , Argentina.

Ricardo D Enriz (RD)

Facultad de Química, Bioquímica y Farmacia , Universidad Nacional de San Luis-IMIBIO-SL-CONICET , Chacabuco 915 , San Luis , Argentina.

Laura Piqueras (L)

Department of Pharmacology , University of Valencia , 46113 Valencia Spain.
Institute of Health Research-INCLIVA , University Clinic Hospital of Valencia , 46010 Valencia , Spain.

Bruno Figadère (B)

UMR CNRS 8076, LERMIT , Université Paris-Sud, UFR de Pharmacie , Châtenay-Malabry 92290 , France.
ORCID: 0000-0003-4226-8489

María-Jesús Sanz (MJ)

Department of Pharmacology , University of Valencia , 46113 Valencia Spain.
Institute of Health Research-INCLIVA , University Clinic Hospital of Valencia , 46010 Valencia , Spain.

Nuria Cabedo (N)

Department of Pharmacology , University of Valencia , 46113 Valencia Spain.
Institute of Health Research-INCLIVA , University Clinic Hospital of Valencia , 46010 Valencia , Spain.
ORCID: 0000-0001-6729-8057

Diego Cortes (D)

Department of Pharmacology , University of Valencia , 46113 Valencia Spain.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Polycerasoidol, a Natural Prenylated...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Polycerasoidol, a Natural Prenylated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Polycerasoidol, a Natural Prenylated...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Polycerasoidol, a Natural Prenylated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR alpha › Polycerasoidol, a Natural Prenylated...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR gamma › Polycerasoidol, a Natural Prenylated...
questionsmedicales.fr › Métabolisme › Prénylation › Polycerasoidol, a Natural Prenylated...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Polycerasoidol, a Natural Prenylated...