TGIF1 functions as a tumor suppressor in pancreatic ductal adenocarcinoma.
Animals
Carcinoma, Pancreatic Ductal
/ genetics
Cell Line, Tumor
Disease Models, Animal
Disease Progression
Gene Expression Regulation, Neoplastic
Homeodomain Proteins
/ genetics
Humans
Mice
Neoplasm Metastasis
Nuclear Proteins
/ genetics
Pancreatic Neoplasms
/ genetics
Proto-Oncogene Proteins p21(ras)
/ genetics
Repressor Proteins
/ genetics
Signal Transduction
Transforming Growth Factor beta
/ metabolism
Twist-Related Protein 1
/ genetics
TGF-β signaling
TGIF1
Twist1
oncogenic Kras
pancreatic ductal adenocarcinoma
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
received:
05
11
2018
revised:
11
04
2019
accepted:
23
04
2019
entrez:
4
7
2019
pubmed:
4
7
2019
medline:
24
12
2019
Statut:
ppublish
Résumé
A prominent function of TGIF1 is suppression of transforming growth factor beta (TGF-β) signaling, whose inactivation is deemed instrumental to the progression of pancreatic ductal adenocarcinoma (PDAC), as exemplified by the frequent loss of the tumor suppressor gene SMAD4 in this malignancy. Surprisingly, we found that genetic inactivation of Tgif1 in the context of oncogenic Kras, Kras
Identifiants
pubmed: 31268604
doi: 10.15252/embj.2018101067
pmc: PMC6601038
doi:
Substances chimiques
Homeodomain Proteins
0
KRAS protein, human
0
Nuclear Proteins
0
Repressor Proteins
0
TGIF1 protein, human
0
TWIST1 protein, human
0
Transforming Growth Factor beta
0
Twist-Related Protein 1
0
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e101067Subventions
Organisme : Association pour la Recherche sur le Cancer
ID : R11120DD
Pays : International
Organisme : NIGMS NIH HHS
ID : P20 GM103476
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR059070
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA210911
Pays : United States
Organisme : National Institute of Health
ID : R01AR059070
Pays : International
Organisme : U. S. Department of Defense (DOD)
ID : PR162051
Pays : International
Organisme : NIGMS NIH HHS
ID : P20 GM121334
Pays : United States
Organisme : National Institute of Health
ID : R01CA210911
Pays : International
Informations de copyright
© 2019 The Authors.
Références
Cancer Cell. 2015 Apr 13;27(4):547-60
pubmed: 25873176
FASEB J. 2007 Feb;21(2):488-96
pubmed: 17158784
Cell Rep. 2015 Feb 17;10(6):883-890
pubmed: 25683711
J Pathol. 2011 Jan;223(2):295-306
pubmed: 21125682
EMBO J. 2001 Jan 15;20(1-2):128-36
pubmed: 11226163
PLoS Genet. 2012;8(2):e1002524
pubmed: 22383895
Cancer Res. 2008 Nov 15;68(22):9459-68
pubmed: 19010921
Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52
pubmed: 16585505
Mol Cell. 2006 Aug;23(4):547-59
pubmed: 16916642
Gastroenterology. 2014 Mar;146(3):822-834.e7
pubmed: 24315826
EMBO J. 2019 Jul 1;38(13):e101067
pubmed: 31268604
Annu Rev Pathol. 2008;3:157-88
pubmed: 18039136
EMBO J. 2008 Jul 9;27(13):1804-15
pubmed: 18511908
Cell Rep. 2013 Aug 15;4(3):530-41
pubmed: 23911286
Cell. 2008 May 16;133(4):704-15
pubmed: 18485877
Annu Rev Cell Dev Biol. 2005;21:659-93
pubmed: 16212511
Cancer Cell. 2014 Jun 16;25(6):719-34
pubmed: 24856586
Genes Dev. 2005 Dec 1;19(23):2783-810
pubmed: 16322555
Oncogene. 2010 Jun 17;29(24):3554-65
pubmed: 20400976
J Biol Chem. 2008 May 23;283(21):14665-73
pubmed: 18353781
Science. 2002 May 31;296(5573):1646-7
pubmed: 12040180
Mol Cell Biol. 2005 May;25(9):3639-47
pubmed: 15831469
Mol Cell. 2009 Dec 25;36(6):1073-85
pubmed: 20064471
Cell. 1999 Apr 2;97(1):29-39
pubmed: 10199400
Cancer Cell. 2010 Nov 16;18(5):448-58
pubmed: 21075310
Cancer Cell. 2004 Apr;5(4):375-87
pubmed: 15093544
Gut. 2012 Jul;61(7):1085-94
pubmed: 21749982
Mech Dev. 2003 Jan;120(1):35-43
pubmed: 12490294
Cancer Cell. 2005 May;7(5):469-83
pubmed: 15894267
PLoS One. 2012;7(5):e35672
pubmed: 22567107
Cell. 2011 Oct 14;147(2):275-92
pubmed: 22000009
J Biol Chem. 1995 Dec 29;270(52):31178-88
pubmed: 8537382
Pancreas. 1999 Nov;19(4):370-6
pubmed: 10547197
Cell. 2008 Jul 25;134(2):215-30
pubmed: 18662538
Genes Dev. 2006 Nov 15;20(22):3147-60
pubmed: 17114585
Cell. 1988 May 20;53(4):549-54
pubmed: 2453289
Nucleic Acids Res. 2018 Feb 16;46(3):1180-1195
pubmed: 29186616
Genes Dev. 2006 May 15;20(10):1218-49
pubmed: 16702400
Curr Top Microbiol Immunol. 2001;254:145-64
pubmed: 11190572
Proc Natl Acad Sci U S A. 2001 May 22;98(11):6198-203
pubmed: 11371641
Curr Opin Cell Biol. 2000 Apr;12(2):235-43
pubmed: 10712925
Gastroenterology. 1993 Dec;105(6):1846-56
pubmed: 8253361
CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300
pubmed: 20610543
Clin Cancer Res. 2012 Aug 15;18(16):4266-76
pubmed: 22896693
Genes Dev. 2006 Nov 15;20(22):3130-46
pubmed: 17114584
Chromosoma. 2016 Jun;125(3):497-521
pubmed: 26464018
Cancer Res. 2011 Jun 1;71(11):3980-90
pubmed: 21502402
Cell. 2004 Jun 25;117(7):927-39
pubmed: 15210113
Cancer Cell. 2012 Sep 11;22(3):404-15
pubmed: 22975381
Dev Cell. 2018 Jun 18;45(6):712-725.e6
pubmed: 29920276
Genes Dev. 2003 Dec 15;17(24):3112-26
pubmed: 14681207
Cell. 2016 Feb 25;164(5):1015-30
pubmed: 26898331
Cell. 2015 Jun 4;161(6):1345-60
pubmed: 26004068
Dev Biol. 2008 Jul 15;319(2):285-97
pubmed: 18508043
N Engl J Med. 2010 Apr 29;362(17):1605-17
pubmed: 20427809
Oncogene. 2008 Sep 18;27(42):5543-53
pubmed: 18504427
Mol Cells. 2009 Oct 31;28(4):315-20
pubmed: 19812895
Genes Dev. 1999 Sep 1;13(17):2207-17
pubmed: 10485844
Mol Cell Biol. 2006 Feb;26(3):990-1001
pubmed: 16428452
Nat Rev Clin Oncol. 2010 Mar;7(3):163-72
pubmed: 20101258
Cancer Cell. 2003 Dec;4(6):437-50
pubmed: 14706336
Mol Cell Biol. 2006 Jun;26(11):4302-10
pubmed: 16705179