Alcohol-induced adipose tissue macrophage phenotypic switching is independent of myeloid Toll-like receptor 4 expression.

Adipocytes / drug effects Adipose Tissue / drug effects Animals Ethanol / pharmacology Inflammation / drug therapy Liver / drug effects Macrophages / drug effects Mice, Transgenic Obesity / drug therapy Toll-Like Receptor 4 / metabolism
TLR4 adipose alcohol inflammation

Journal

American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225

Informations de publication

Date de publication:
01 10 2019
Historique:
pubmed: 4 7 2019
medline: 9 4 2020
entrez: 4 7 2019
Statut: ppublish

Résumé

Alcoholic liver disease results from a combination of immune and metabolic pathogenic events. In addition to liver injury, chronic alcohol consumption also causes adipose tissue inflammation. The specific immune mechanisms that drive this process are unknown. Here, we sought to determine the role of the innate immune receptor Toll-like receptor 4 (TLR4) in alcohol-induced adipose tissue inflammation. Using a model of chronic, multiple-binge alcohol exposure, we showed that alcohol-mediated accumulation of proinflammatory adipose tissue macrophages was absent in global TLR4 knockout mice. Proinflammatory macrophage accumulation did not depend on macrophage TLR4 expression; LysMCre-driven deletion of

Identifiants

DOI: 10.1152/ajpcell.00276.2017 PMID: 31268779 PMC: PMC6850994
pubmed: 31268779
doi: 10.1152/ajpcell.00276.2017
pmc: PMC6850994
doi:

Substances chimiques

Tlr4 protein, mouse 0
Toll-Like Receptor 4 0
Ethanol 3K9958V90M

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

C687-C700

Subventions

Organisme : NIAAA NIH HHS
ID : R01 AA017986
Pays : United States

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Auteurs

Melissa A Fulham (MA)

Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts.
Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.

Anuradha Ratna (A)

Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.

Rachel M Gerstein (RM)

Program in Innate Immunity, University of Massachusetts Medical School, Worcester, Massachusetts.
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts.

Evelyn A Kurt-Jones (EA)

Program in Innate Immunity, University of Massachusetts Medical School, Worcester, Massachusetts.
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.

Pranoti Mandrekar (P)

Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, Massachusetts.
Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts.
Program in Innate Immunity, University of Massachusetts Medical School, Worcester, Massachusetts.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › Alcohol-induced adipose tissue macrophage...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Alcohol-induced adipose tissue macrophage...
questionsmedicales.fr › Eucaryotes › Animaux › Alcohol-induced adipose tissue macrophage...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Alcohol-induced adipose tissue macrophage...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Alcohol-induced adipose tissue macrophage...
questionsmedicales.fr › Système digestif › Foie › Alcohol-induced adipose tissue macrophage...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Alcohol-induced adipose tissue macrophage...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Alcohol-induced adipose tissue macrophage...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Alcohol-induced adipose tissue macrophage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-4 › Alcohol-induced adipose tissue macrophage...