Atrial Natriuretic Peptide: A Molecular Target of Novel Therapeutic Approaches to Cardio-Metabolic Disease.
atrial natriuretic peptide
cGMP
cardiometabolic disease
guanylyl cyclase receptor A
heart failure
hypertension
metabolic syndrome
natriuretic peptides.
obesity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Jul 2019
02 Jul 2019
Historique:
received:
16
06
2019
revised:
28
06
2019
accepted:
29
06
2019
entrez:
5
7
2019
pubmed:
5
7
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Atrial natriuretic peptide (ANP) is a cardiac hormone with pleiotropic cardiovascular and metabolic properties including vasodilation, natriuresis and suppression of the renin-angiotensin-aldosterone system. Moreover, ANP induces lipolysis, lipid oxidation, adipocyte browning and ameliorates insulin sensitivity. Studies on ANP genetic variants revealed that subjects with higher ANP plasma levels have lower cardio-metabolic risk. In vivo and in humans, augmenting the ANP pathway has been shown to exert cardiovascular therapeutic actions while ameliorating the metabolic profile. MANP is a novel designer ANP-based peptide with greater and more sustained biological actions than ANP in animal models. Recent studies also demonstrated that MANP lowers blood pressure and inhibits aldosterone in hypertensive subjects whereas cardiometabolic properties of MANP are currently tested in an on-going clinical study in hypertension and metabolic syndrome. Evidence from in vitro, in vivo and in human studies support the concept that ANP and related pathway represent an optimal target for a comprehensive approach to cardiometabolic disease.
Identifiants
pubmed: 31269783
pii: ijms20133265
doi: 10.3390/ijms20133265
pmc: PMC6651335
pii:
doi:
Substances chimiques
Atrial Natriuretic Factor
85637-73-6
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Heart Lung and Blood Institute
ID : RO1 HL36634
Organisme : National Heart Lung and Blood Institute
ID : RO1 HL136340
Organisme : American Heart Association
ID : 16SDG29930003
Organisme : Marie Ingalls Cardiovascular Research Career Development Fund in honor of Dr Alexander Schirger
ID : Career Development Award
Déclaration de conflit d'intérêts
Mayo Clinic has licensed MANP to Zumbro Discovery; John C. Burnett Jr. is Co-Founder of Zumbro Discovery and holds equity.
Références
Lancet. 2010 Jan 16;375(9710):181-3
pubmed: 20109902
Mayo Clin Proc. 2018 Aug;93(8):980-990
pubmed: 30077215
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14730-5
pubmed: 9405681
J Clin Invest. 2012 Mar;122(3):1022-36
pubmed: 22307324
Diabetes. 2015 Dec;64(12):4033-45
pubmed: 26253614
Hypertension. 2017 Jan;69(1):32-41
pubmed: 27849566
Nat Med. 2005 Oct;11(10):1096-103
pubmed: 16155579
Circ J. 2008 Nov;72(11):1777-86
pubmed: 18832779
Clin Sci (Lond). 2016 Jul 1;130(13):1105-14
pubmed: 27129190
Hypertension. 2005 Jan;45(1):9-14
pubmed: 15583075
Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H777-84
pubmed: 15778276
N Engl J Med. 2019 Feb 7;380(6):539-548
pubmed: 30415601
PLoS One. 2012;7(8):e43238
pubmed: 22916229
PLoS One. 2014 Feb 19;9(2):e89201
pubmed: 24586593
JACC Heart Fail. 2019 Oct;7(10):891-898
pubmed: 31521687
J Mol Cell Cardiol. 2011 Apr;50(4):695-701
pubmed: 21276798
Diabetes Care. 2005 Jul;28(7):1769-78
pubmed: 15983333
Sci Rep. 2018 Jan 18;8(1):1097
pubmed: 29348496
J Biol Chem. 2011 Feb 11;286(6):4670-9
pubmed: 21098034
Circ Cardiovasc Genet. 2015 Feb;8(1):141-9
pubmed: 25452597
Nat Genet. 2009 Mar;41(3):348-53
pubmed: 19219041
Hypertension. 2003 Jul;42(1):88-95
pubmed: 12756220
J Clin Endocrinol Metab. 2005 Jun;90(6):3622-8
pubmed: 15741263
Circulation. 2018 Jan 9;137(2):109-118
pubmed: 29133599
J Am Coll Cardiol. 2012 Oct 16;60(16):1558-65
pubmed: 23058313
Am J Med. 2006 Oct;119(10):812-9
pubmed: 17000207
J Clin Invest. 2013 Aug;123(8):3378-82
pubmed: 23867623
J Am Coll Cardiol. 2009 Jun 2;53(22):2070-7
pubmed: 19477358
Circulation. 2015 Jan 27;131(4):e29-322
pubmed: 25520374
Circulation. 2019 Mar 5;139(10):e56-e528
pubmed: 30700139
J Cardiol. 2010 Nov;56(3):262-70
pubmed: 20884176
Hypertension. 2004 Aug;44(2):127-33
pubmed: 15262911
Hypertension. 2003 Dec;42(6):1206-52
pubmed: 14656957
Int J Cardiol. 2014 Oct 20;176(3):1249-51
pubmed: 25129277
PLoS One. 2017 Dec 18;12(12):e0189858
pubmed: 29253899
Hypertension. 2004 Mar;43(3):518-24
pubmed: 14732721
Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R104-14
pubmed: 27101299
Diabetes. 2008 Dec;57(12):3199-204
pubmed: 18835931
J Clin Invest. 2012 Dec;122(12):4675-9
pubmed: 23114600
J Am Coll Cardiol. 2009 Jun 2;53(22):2078-9
pubmed: 19477359
BMC Med Genet. 2013 Jun 24;14:64
pubmed: 23799939
Hypertension. 2018 Jun;71(6):e13-e115
pubmed: 29133356
Eur J Heart Fail. 2019 May;21(5):598-605
pubmed: 30520545
Clin Pharmacol Ther. 2017 Feb;101(2):254-263
pubmed: 27542885
J Am Heart Assoc. 2014 Jan 02;3(1):e000206
pubmed: 24385449
Clin Sci (Lond). 2016 Jan;130(2):57-77
pubmed: 26637405
Hypertension. 2010 Dec;56(6):1152-9
pubmed: 20975033
J Am Coll Cardiol. 2009 Sep 8;54(11):1024-32
pubmed: 19729120
Obesity (Silver Spring). 2016 Apr;24(4):820-8
pubmed: 26887289
N Engl J Med. 2014 Sep 11;371(11):993-1004
pubmed: 25176015
Int J Obes (Lond). 2016 Apr;40(4):714-20
pubmed: 26499437
Circ J. 2008 Nov;72(11):1787-93
pubmed: 18812677
J Am Coll Cardiol. 2011 Aug 2;58(6):629-36
pubmed: 21798427
Lancet Diabetes Endocrinol. 2017 May;5(5):333-340
pubmed: 28330649
J Clin Invest. 1998 Feb 15;101(4):812-8
pubmed: 9466976
J Biol Chem. 2009 Jul 17;284(29):19196-202
pubmed: 19458086
J Clin Invest. 2003 May;111(9):1399-407
pubmed: 12727932
J Lipid Res. 2001 Apr;42(4):536-44
pubmed: 11290825
Diabetologia. 2007 May;50(5):1038-47
pubmed: 17318625
Peptides. 2007 Apr;28(4):893-9
pubmed: 17267074
Diabetes Care. 2013 Sep;36(9):2850-6
pubmed: 23637347
NCHS Data Brief. 2015 Nov;(220):1-8
pubmed: 26633197
J Clin Endocrinol Metab. 2012 Feb;97(2):638-45
pubmed: 22112816
Hypertension. 2015 Jan;65(1):45-53
pubmed: 25368032
Nat Med. 2004 Dec;10(12):1384-9
pubmed: 15558058
Science. 1995 Feb 3;267(5198):679-81
pubmed: 7839143
J Am Coll Cardiol. 2004 May 19;43(10):1817-22
pubmed: 15145106
Circulation. 2004 Feb 10;109(5):594-600
pubmed: 14769680
J Am Coll Cardiol. 2019 Mar 26;73(11):1273-1284
pubmed: 30898202
Nat Med. 2002 Jul;8(7):731-7
pubmed: 12068289
Trends Endocrinol Metab. 2006 Aug;17(6):251-8
pubmed: 16815030
Circulation. 2007 Mar 20;115(11):1345-53
pubmed: 17339551
Biochimie. 2016 May;124:84-91
pubmed: 26037452
Circulation. 2014 Nov 4;130(19):1692-9
pubmed: 25332288
Circ J. 2005 Mar;69(3):283-90
pubmed: 15731532