Acute elevation of serum inflammatory markers predicts symptom recovery after concussion.
Adolescent
Athletes
Athletic Injuries
/ immunology
Brain Concussion
/ immunology
C-Reactive Protein
/ immunology
Cytokines
/ immunology
Football
/ injuries
Humans
Interferon-gamma
/ immunology
Interleukin 1 Receptor Antagonist Protein
/ immunology
Interleukin-10
/ immunology
Interleukin-1beta
/ immunology
Interleukin-6
/ immunology
Male
Prognosis
Recovery of Function
Tumor Necrosis Factor-alpha
/ immunology
Young Adult
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
30 07 2019
30 07 2019
Historique:
received:
18
12
2018
accepted:
14
03
2019
pubmed:
5
7
2019
medline:
7
1
2020
entrez:
5
7
2019
Statut:
ppublish
Résumé
To test the hypothesis that acute elevations in serum inflammatory markers predict symptom recovery after sport-related concussion (SRC). High school and collegiate football players (n = 857) were prospectively enrolled. Forty-one athletes with concussion and 43 matched control athletes met inclusion criteria. Serum levels of interleukin (IL)-6, IL-1β, IL-10, tumor necrosis factor, C-reactive protein, interferon-γ, and IL-1 receptor antagonist and Sport Concussion Assessment Tool, 3rd edition (SCAT3) symptom severity scores were collected at a preinjury baseline, 6 and 24-48 hours postinjury, and approximately 8, 15, and 45 days following concussion. The number of days that athletes were symptomatic following SRC (i.e., duration of symptoms) was the primary outcome variable. IL-6 and IL-1RA were significantly elevated in athletes with concussion at 6 hours relative to preinjury and other postinjury visits, as well as compared to controls ( Results support the potential utility of IL-6 and IL-1RA as serum biomarkers of SRC and demonstrate the potential of these markers in identifying athletes at risk for prolonged recovery after SRC. This study provides Class III evidence that serum levels of IL-6 and IL-1RA 6 hours postconcussion significantly discriminated concussed from control athletes.
Identifiants
pubmed: 31270219
pii: WNL.0000000000007864
doi: 10.1212/WNL.0000000000007864
pmc: PMC6693429
doi:
Substances chimiques
Cytokines
0
IL10 protein, human
0
IL1B protein, human
0
IL1RN protein, human
0
IL6 protein, human
0
Interleukin 1 Receptor Antagonist Protein
0
Interleukin-1beta
0
Interleukin-6
0
TNF protein, human
0
Tumor Necrosis Factor-alpha
0
Interleukin-10
130068-27-8
Interferon-gamma
82115-62-6
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e497-e507Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001436
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102225
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS099789
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121312
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH113871
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2019 American Academy of Neurology.
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