From conception to infancy - early risk factors for childhood obesity.
Journal
Nature reviews. Endocrinology
ISSN: 1759-5037
Titre abrégé: Nat Rev Endocrinol
Pays: England
ID NLM: 101500078
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
accepted:
10
05
2019
pubmed:
5
7
2019
medline:
27
2
2020
entrez:
5
7
2019
Statut:
ppublish
Résumé
Maternal lifestyle during pregnancy, as well as early nutrition and the environment infants are raised in, are considered relevant factors for the prevention of childhood obesity. Several models are available for the prediction of childhood overweight and obesity, yet most have not been externally validated. Moreover, the factors considered in the models differ among studies as the outcomes manifest after birth and depend on maturation processes that vary between individuals. The current Review examines and interprets data on the early determinants of childhood obesity to provide relevant strategies for daily clinical work. We evaluate a selection of prenatal and postnatal factors associated with child adiposity. Actions to be considered for preventing childhood obesity include the promotion of healthy maternal nutrition and weight status at reproductive age and during pregnancy, as well as careful monitoring of infant growth to detect early excessive weight gain. Paediatricians and other health-care professionals should provide scientifically validated, individual nutritional advice to families to counteract excessive adiposity in children. Based on systematic reviews, original papers and scientific reports, we provide information to help with setting up public health strategies to prevent overweight and obesity in childhood.
Identifiants
pubmed: 31270440
doi: 10.1038/s41574-019-0219-1
pii: 10.1038/s41574-019-0219-1
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
456-478Références
Marginean, C. O., Marginean, C. & Melit, L. E. New insights regarding genetic aspects of childhood obesity: a minireview. Front. Pediatr. 6, 271 (2018).
pubmed: 30338250
pmcid: 6180186
doi: 10.3389/fped.2018.00271
Silventoinen, K. et al. Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study. Am. J. Clin. Nutr. 104, 371–379 (2016).
pubmed: 27413137
pmcid: 4962159
doi: 10.3945/ajcn.116.130252
Schrempft, S. et al. Variation in the heritability of child body mass index by obesogenic home environment. JAMA Pediatr. 172, 1153–1160 (2018).
pubmed: 30285028
pmcid: 6396810
doi: 10.1001/jamapediatrics.2018.1508
Woo Baidal, J. A. et al. Risk factors for childhood obesity in the first 1,000 days: a systematic review. Am. J. Prev. Med. 50, 761–779 (2016).
pubmed: 26916261
doi: 10.1016/j.amepre.2015.11.012
Li, A. et al. Parental and child genetic contributions to obesity traits in early life based on 83 loci validated in adults: the FAMILY study. Pediatr. Obes. 13, 133–140 (2018).
pubmed: 28008729
doi: 10.1111/ijpo.12205
Munthali, R. J. et al. Genetic risk score for adult body mass index associations with childhood and adolescent weight gain in an African population. Genes Nutr. 13, 24 (2018).
pubmed: 30123368
pmcid: 6090951
doi: 10.1186/s12263-018-0613-7
Black, R. E. et al. Maternal and child undernutrition and overweight in low-income and middle-income countries. Lancet 382, 427–451 (2013).
pubmed: 23746772
doi: 10.1016/S0140-6736(13)60937-X
Swinburn, B. A. et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet 378, 804–814 (2011).
pubmed: 21872749
doi: 10.1016/S0140-6736(11)60813-1
Ng, M. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384, 766–781 (2014).
pubmed: 24880830
pmcid: 4624264
doi: 10.1016/S0140-6736(14)60460-8
NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. Lancet 390, 2627–2642 (2017).
doi: 10.1016/S0140-6736(17)32129-3
Twig, G. et al. Body-mass index in 2.3 million adolescents and cardiovascular death in adulthood. N. Engl. J. Med. 374, 2430–2440 (2016).
pubmed: 27074389
doi: 10.1056/NEJMoa1503840
Lo, J. C. et al. Prevalence of obesity and extreme obesity in children aged 3–5 years. Pediatr. Obes. 9, 167–175 (2014).
Haddad, L. et al. The Global Nutrition Report 2014: actions and accountability to accelerate the world’s progress on nutrition. J. Nutr. 145, 663–671 (2015).
pubmed: 25740908
doi: 10.3945/jn.114.206078
Ward, Z. J. et al. Simulation of growth trajectories of childhood obesity into adulthood. N. Engl. J. Med. 377, 2145–2153 (2017).
pubmed: 29171811
doi: 10.1056/NEJMoa1703860
Geserick, M. et al. Acceleration of BMI in early childhood and risk of sustained obesity. N. Engl. J. Med. 379, 1303–1312 (2018).
pubmed: 30281992
doi: 10.1056/NEJMoa1803527
Abdullah, A. et al. The number of years lived with obesity and the risk of all-cause and cause-specific mortality. Int. J. Epidemiol. 40, 985–996 (2011).
pubmed: 21357186
doi: 10.1093/ije/dyr018
World Health Organization. Childhood overweight and obesity. WHO https://www.who.int/dietphysicalactivity/childhood/en/ (2018).
de Onis, M., Blossner, M. & Borghi, E. Global prevalence and trends of overweight and obesity among preschool children. Am. J. Clin. Nutr. 92, 1257–1264 (2010).
pubmed: 20861173
doi: 10.3945/ajcn.2010.29786
World Health Organization. Overweight and obesity. WHO https://www.who.int/gho/ncd/risk_factors/overweight_obesity/overweight_adolescents/en/ (2016).
Chung, A. et al. Trends in child and adolescent obesity prevalence in economically advanced countries according to socioeconomic position: a systematic review. Obes. Rev. 17, 276–295 (2016).
pubmed: 26693831
doi: 10.1111/obr.12360
Yuan, Z. P. et al. Possible role of birth weight on general and central obesity in Chinese children and adolescents: a cross-sectional study. Ann. Epidemiol. 25, 748–752 (2015).
pubmed: 26198137
doi: 10.1016/j.annepidem.2015.05.011
Rogers, I. The influence of birth weight and intrauterine environment on adiposity and fat distribution in later life. Int. J. Obes. Relat. Metab. Disord. 27, 755–777 (2003).
pubmed: 12821960
doi: 10.1038/sj.ijo.0802316
Rockenbach, G. et al. Sex-specific associations of birth weight with measures of adiposity in mid-to-late adulthood: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Int. J. Obes. 40, 1286–1291 (2016).
doi: 10.1038/ijo.2016.76
Logan, K. M., Gale, C., Hyde, M. J., Santhakumaran, S. & Modi, N. Diabetes in pregnancy and infant adiposity: systematic review and meta-analysis. Arch. Dis. Child Fetal Neonatal Ed. 102, F65–F72 (2017).
pubmed: 27231266
doi: 10.1136/archdischild-2015-309750
Starling, A. P. et al. Associations of maternal BMI and gestational weight gain with neonatal adiposity in the Healthy Start Study. Am. J. Clin. Nutr. 101, 302–309 (2015).
pubmed: 25646327
doi: 10.3945/ajcn.114.094946
Weng, S. F., Redsell, S. A., Swift, J. A., Yang, M. & Glazebrook, C. P. Systematic review and meta-analyses of risk factors for childhood overweight identifiable during infancy. Arch. Dis. Child 97, 1019–1026 (2012).
pubmed: 23109090
doi: 10.1136/archdischild-2012-302263
Blencowe, H. et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet 379, 2162–2172 (2012).
pubmed: 22682464
doi: 10.1016/S0140-6736(12)60820-4
Harrison, M. S. & Goldenberg, R. L. Global burden of prematurity. Semin. Fetal Neonatal Med. 21, 74–79 (2016).
pubmed: 26740166
doi: 10.1016/j.siny.2015.12.007
Labayen, I. et al. Early life programming of abdominal adiposity in adolescents: the HELENA Study. Diabetes Care 32, 2120–2122 (2009).
pubmed: 19641158
pmcid: 2768211
doi: 10.2337/dc09-0983
Lee, A. C. et al. Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21
pubmed: 28819030
pmcid: 5558898
doi: 10.1136/bmj.j3677
Lee, A. C. et al. National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010. Lancet Glob. Health 1, e26–e36 (2013).
pubmed: 25103583
pmcid: 4221634
doi: 10.1016/S2214-109X(13)70006-8
Ferrara, A. Increasing prevalence of gestational diabetes mellitus: a public health perspective. Diabetes Care 30 (Suppl. 2), 141–146 (2007).
doi: 10.2337/dc07-s206
Hunt, K. J. & Schuller, K. L. The increasing prevalence of diabetes in pregnancy. Obstet. Gynecol. Clin. North Am. 34, 173–199 (2007).
pubmed: 17572266
pmcid: 2043158
doi: 10.1016/j.ogc.2007.03.002
Baerug, A. et al. Recent gestational diabetes was associated with mothers stopping predominant breastfeeding earlier in a multi-ethnic population. Acta Paediatr. 107, 1028–1035 (2018).
pubmed: 29432660
doi: 10.1111/apa.14274
Nguyen, C. L., Pham, N. M., Binns, C. W., Duong, D. V. & Lee, A. H. Prevalence of gestational diabetes mellitus in eastern and southeastern Asia: a systematic review and meta-analysis. J. Diabetes Res. 2018, 6536974 (2018).
pubmed: 29675432
pmcid: 5838488
doi: 10.1155/2018/6536974
Lin, X. et al. Ethnic differences in effects of maternal pre-pregnancy and pregnancy adiposity on offspring size and adiposity. J. Clin. Endocrinol. Metab. 100, 3641–3650 (2015).
pubmed: 26200236
pmcid: 4628100
doi: 10.1210/jc.2015-1728
Castillo, H., Santos, I. S. & Matijasevich, A. Relationship between maternal pre-pregnancy body mass index, gestational weight gain and childhood fatness at 6–7 years by air displacement plethysmography. Matern. Child Nutr. 11, 606–617 (2015).
pubmed: 25850519
pmcid: 4832361
doi: 10.1111/mcn.12186
Widen, E. M. et al. Gestational weight gain and obesity, adiposity and body size in African-American and Dominican children in the Bronx and Northern Manhattan. Matern. Child Nutr. 12, 918–928 (2016).
pubmed: 25753294
doi: 10.1111/mcn.12174
Jacota, M., Forhan, A., Saldanha-Gomes, C., Charles, M. A. & Heude, B. Maternal weight prior and during pregnancy and offspring’s BMI and adiposity at 5-6 years in the EDEN mother-child cohort. Pediatr. Obes. 12, 320–329 (2016).
pubmed: 27135441
doi: 10.1111/ijpo.12145
Hinkle, S. N. et al. Excess gestational weight gain is associated with child adiposity among mothers with normal and overweight prepregnancy weight status. J. Nutr. 142, 1851–1858 (2012).
pubmed: 22955516
pmcid: 6498456
doi: 10.3945/jn.112.161158
Scott, C. et al. No global consensus: a cross-sectional survey of maternal weight policies. BMC Pregnancy Childbirth 14, 167 (2014).
pubmed: 24884985
pmcid: 4031379
doi: 10.1186/1471-2393-14-167
Rasmussen, K. M. & Yaktine, A. L. (eds) Weight Gain During Pregnancy: Reexamining the Guidelines (National Academies Press, 2009).
Hivert, M. F., Rifas-Shiman, S. L., Gillman, M. W. & Oken, E. Greater early and mid-pregnancy gestational weight gains are associated with excess adiposity in mid-childhood. Obesity 24, 1546–1553 (2016).
pubmed: 27345963
doi: 10.1002/oby.21511
Kral, J. G. et al. Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years. Pediatrics 118, e1644–e1649 (2006).
pubmed: 17142494
doi: 10.1542/peds.2006-1379
Smith, J. et al. Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity. J. Clin. Endocrinol. Metab. 94, 4275–4283 (2009).
pubmed: 19820018
doi: 10.1210/jc.2009-0709
Branum, A. M., Parker, J. D., Keim, S. A. & Schempf, A. H. Prepregnancy body mass index and gestational weight gain in relation to child body mass index among siblings. Am. J. Epidemiol. 174, 1159–1165 (2011).
pubmed: 21984656
doi: 10.1093/aje/kwr250
Lawlor, D. A., Lichtenstein, P., Fraser, A. & Langstrom, N. Does maternal weight gain in pregnancy have long-term effects on offspring adiposity? A sibling study in a prospective cohort of 146,894 men from 136,050 families. Am. J. Clin. Nutr. 94, 142–148 (2011).
pubmed: 21562086
pmcid: 3127508
doi: 10.3945/ajcn.110.009324
Villamor, E. & Cnattingius, S. Interpregnancy weight change and risk of adverse pregnancy outcomes: a population-based study. Lancet 368, 1164–1170 (2006).
pubmed: 17011943
doi: 10.1016/S0140-6736(06)69473-7
Patro, B. et al. Maternal and paternal body mass index and offspring obesity: a systematic review. Ann. Nutr. Metab. 63, 32–41 (2013).
pubmed: 23887153
doi: 10.1159/000350313
Lawlor, D. A. et al. Epidemiologic evidence for the fetal overnutrition hypothesis: findings from the mater-university study of pregnancy and its outcomes. Am. J. Epidemiol. 165, 418–424 (2007).
pubmed: 17158475
doi: 10.1093/aje/kwk030
Fleten, C. et al. Parent-offspring body mass index associations in the Norwegian Mother and Child Cohort Study: a family-based approach to studying the role of the intrauterine environment in childhood adiposity. Am. J. Epidemiol. 176, 83–92 (2012).
pubmed: 22771730
pmcid: 3493198
doi: 10.1093/aje/kws134
Sorensen, T. et al. Comparison of associations of maternal peri-pregnancy and paternal anthropometrics with child anthropometrics from birth through age 7 y assessed in the Danish National Birth Cohort. Am. J. Clin. Nutr. 104, 389–396 (2016).
pubmed: 27413126
doi: 10.3945/ajcn.115.129171
Gaillard, R. et al. Childhood cardiometabolic outcomes of maternal obesity during pregnancy: the Generation R Study. Hypertension 63, 683–691 (2014).
pubmed: 24379180
doi: 10.1161/HYPERTENSIONAHA.113.02671
Linabery, A. M. et al. Stronger influence of maternal than paternal obesity on infant and early childhood body mass index: the Fels Longitudinal Study. Pediatr. Obes. 8, 159–169 (2013).
pubmed: 23042783
doi: 10.1111/j.2047-6310.2012.00100.x
Whitaker, R. C., Deeks, C. M., Baughcum, A. E. & Specker, B. L. The relationship of childhood adiposity to parent body mass index and eating behavior. Obes. Res. 8, 234–240 (2000).
pubmed: 10832766
doi: 10.1038/oby.2000.27
Lawlor, D. A., Lichtenstein, P. & Langstrom, N. Association of maternal diabetes mellitus in pregnancy with offspring adiposity into early adulthood: sibling study in a prospective cohort of 280,866 men from 248,293 families. Circulation 123, 258–265 (2011).
pubmed: 21220735
pmcid: 4440894
doi: 10.1161/CIRCULATIONAHA.110.980169
Patro Golab, B. et al. Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis. Lancet Child Adolesc. Health 2, 812–821 (2018).
pubmed: 30201470
doi: 10.1016/S2352-4642(18)30273-6
Brown, J. et al. Lifestyle interventions for the treatment of women with gestational diabetes. Cochrane Database Syst. Rev. 5, CD011970 (2017).
pubmed: 28472859
Ravelli, A. C., van Der Meulen, J. H., Osmond, C., Barker, D. J. & Bleker, O. P. Obesity at the age of 50 y in men and women exposed to famine prenatally. Am. J. Clin. Nutr. 70, 811–816 (1999).
pubmed: 10539740
doi: 10.1093/ajcn/70.5.811
Wang, Y., Wang, X., Kong, Y., Zhang, J. H. & Zeng, Q. The Great Chinese Famine leads to shorter and overweight females in Chongqing Chinese population after 50 years. Obesity 18, 588–592 (2010).
pubmed: 19779478
doi: 10.1038/oby.2009.296
Stanner, S. A. et al. Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study. BMJ 315, 1342–1348 (1997).
pubmed: 9402775
pmcid: 2127836
doi: 10.1136/bmj.315.7119.1342
Hult, M. et al. Hypertension, diabetes and overweight: looming legacies of the Biafran famine. PLOS ONE 5, e13582 (2010).
pubmed: 21042579
pmcid: 2962634
doi: 10.1371/journal.pone.0013582
Bhutta, Z. A. et al. Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost? Lancet 382, 452–477 (2013).
pubmed: 23746776
doi: 10.1016/S0140-6736(13)60996-4
Khan, M. N., Rahman, M. M., Shariff, A. A., Rahman, M. S. & Rahman, M. A. Maternal undernutrition and excessive body weight and risk of birth and health outcomes. Arch. Public Health 75, 12 (2017).
pubmed: 28174626
pmcid: 5291969
doi: 10.1186/s13690-017-0181-0
Min, J., Zhao, Y., Slivka, L. & Wang, Y. Double burden of diseases worldwide: coexistence of undernutrition and overnutrition-related non-communicable chronic diseases. Obes. Rev. 19, 49–61 (2018).
pubmed: 28940822
doi: 10.1111/obr.12605
Sinha, B. et al. Low-birthweight infants born to short-stature mothers are at additional risk of stunting and poor growth velocity: evidence from secondary data analyses. Matern. Child Nutr. 14, e12504 (2018).
doi: 10.1111/mcn.12504
Kozuki, N. et al. Short maternal stature increases risk of small-for-gestational-age and preterm births in low- and middle-income countries: individual participant data meta-analysis and population attributable fraction. J. Nutr. 145, 2542–2550 (2015).
pubmed: 26423738
doi: 10.3945/jn.115.216374
World Health Organization. Assessing and Managing Children at Primary Health-Care Facilities to Prevent Overweight and Obesity in the Context of the Double Burden of Malnutrition (WHO, 2017).
Azcorra, H., Dickinson, F. & Datta Banik, S. Maternal height and its relationship to offspring birth weight and adiposity in 6- to 10-year-old Maya children from poor neighborhoods in Merida, Yucatan. Am. J. Phys. Anthropol. 161, 571–579 (2016).
pubmed: 27465976
doi: 10.1002/ajpa.23057
Wilson, H. J. et al. Maternal short stature does not predict their children’s fatness indicators in a nutritional dual-burden sample of urban Mexican Maya. Am. J. Phys. Anthropol. 153, 627–634 (2014).
pubmed: 24375238
doi: 10.1002/ajpa.22463
Varela-Silva, M. I., Azcorra, H., Dickinson, F., Bogin, B. & Frisancho, A. R. Influence of maternal stature, pregnancy age, and infant birth weight on growth during childhood in Yucatan, Mexico: a test of the intergenerational effects hypothesis. Am. J. Hum. Biol. 21, (657–663 (2009).
Oken, E., Levitan, E. B. & Gillman, M. W. Maternal smoking during pregnancy and child overweight: systematic review and meta-analysis. Int. J. Obes. 32, 201–210 (2008).
doi: 10.1038/sj.ijo.0803760
Li, L. et al. Maternal smoking in pregnancy association with childhood adiposity and blood pressure. Pediatr. Obes. 11, 202–209 (2016).
pubmed: 26178147
doi: 10.1111/ijpo.12046
Ino, T. Maternal smoking during pregnancy and offspring obesity: meta-analysis. Pediatr. Int. 52, 94–99 (2010).
pubmed: 19400912
doi: 10.1111/j.1442-200X.2009.02883.x
Flak, A. L. et al. The association of mild, moderate, and binge prenatal alcohol exposure and child neuropsychological outcomes: a meta-analysis. Alcohol Clin. Exp. Res. 38, 214–226 (2014).
pubmed: 23905882
doi: 10.1111/acer.12214
Dobson, C. C. et al. Chronic prenatal ethanol exposure increases adiposity and disrupts pancreatic morphology in adult guinea pig offspring. Nutr. Diabetes 2, e57 (2012).
pubmed: 23247731
pmcid: 3542435
doi: 10.1038/nutd.2012.31
Zhang, C. R. et al. Early gestational ethanol exposure in mice: effects on brain structure, energy metabolism and adiposity in adult offspring. Alcohol 75, 1–10 (2018).
pubmed: 30316966
doi: 10.1016/j.alcohol.2018.04.008
Strandberg-Larsen, K. et al. Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts. Eur. J. Epidemiol. 32, 751–764 (2017).
pubmed: 29027084
doi: 10.1007/s10654-017-0323-2
Mamluk, L. et al. Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe’ levels of alcohol during pregnancy? A systematic review and meta-analyses. BMJ Open 7, e015410 (2017).
pubmed: 28775124
pmcid: 5642770
doi: 10.1136/bmjopen-2016-015410
Patra, J. et al. Dose-response relationship between alcohol consumption before and during pregnancy and the risks of low birthweight, preterm birth and small for gestational age (SGA)-a systematic review and meta-analyses. BJOG 118, 1411–1421 (2011).
pubmed: 21729235
pmcid: 3394156
doi: 10.1111/j.1471-0528.2011.03050.x
Brion, M. J. et al. Maternal macronutrient and energy intakes in pregnancy and offspring intake at 10 y: exploring parental comparisons and prenatal effects. Am. J. Clin. Nutr. 91, 748–756 (2010).
pubmed: 20053880
pmcid: 2822901
doi: 10.3945/ajcn.2009.28623
Khoury, J., Henriksen, T., Christophersen, B. & Tonstad, S. Effect of a cholesterol-lowering diet on maternal, cord, and neonatal lipids, and pregnancy outcome: a randomized clinical trial. Am. J. Obstet. Gynecol. 193, 1292–1301 (2005).
pubmed: 16202717
doi: 10.1016/j.ajog.2005.05.016
Kinnunen, T. I. et al. Preventing excessive weight gain during pregnancy - a controlled trial in primary health care. Eur. J. Clin. Nutr. 61, 884–891 (2007).
pubmed: 17228348
doi: 10.1038/sj.ejcn.1602602
Shapiro, A. L. et al. Infant adiposity is independently associated with a maternal high fat diet but not related to niacin intake: the Healthy Start Study. Matern. Child Health J. 21, 1662–1668 (2017).
pubmed: 28161859
pmcid: 5517356
doi: 10.1007/s10995-016-2258-8
Chen, L. W. et al. Associations of maternal macronutrient intake during pregnancy with infant BMI peak characteristics and childhood BMI. Am. J. Clin. Nutr. 105, 705–713 (2017).
pubmed: 28179222
doi: 10.3945/ajcn.116.148270
Tielemans, M. J. et al. Protein intake during pregnancy and offspring body composition at 6 years: the Generation R Study. Eur. J. Nutr. 56, 2151–2160 (2016).
pubmed: 27376355
pmcid: 5579175
doi: 10.1007/s00394-016-1255-4
Vidakovic, A. J. et al. Maternal plasma PUFA concentrations during pregnancy and childhood adiposity: the Generation R Study. Am. J. Clin. Nutr. 103, 1017–1025 (2016).
pubmed: 26912493
doi: 10.3945/ajcn.115.112847
Hakola, L. et al. Maternal fatty acid intake during pregnancy and the development of childhood overweight: a birth cohort study. Pediatr. Obes. 12, S26–S37 (2016).
doi: 10.1111/ijpo.12170
Stratakis, N. et al. Fish intake in pregnancy and child growth: a pooled analysis of 15 European and US birth cohorts. JAMA Pediatr. 170, 381–390 (2016).
pubmed: 26882542
pmcid: 5103635
doi: 10.1001/jamapediatrics.2015.4430
US Food & Drug Administration. Eating fish: what pregnant women and parents should know. FDA https://www.fda.gov/Food/FoodborneIllnessContaminants/Metals/ucm393070.htm (2014).
Moses, R. G. et al. Effect of a low-glycemic-index diet during pregnancy on obstetric outcomes. Am. J. Clin. Nutr. 84, 807–812 (2006).
pubmed: 17023707
doi: 10.1093/ajcn/84.4.807
Murrin, C., Shrivastava, A. & Kelleher, C. C. Maternal macronutrient intake during pregnancy and 5 years postpartum and associations with child weight status aged five. Eur. J. Clin. Nutr. 67, 670–679 (2013).
pubmed: 23612514
doi: 10.1038/ejcn.2013.76
Jen, V. et al. Mothers’ intake of sugar-containing beverages during pregnancy and body composition of their children during childhood: the Generation R Study. Am. J. Clin. Nutr. 105, 834–841 (2017).
pubmed: 28275130
doi: 10.3945/ajcn.116.147934
Tieu, J., Shepherd, E., Middleton, P. & Crowther, C. A. Dietary advice interventions in pregnancy for preventing gestational diabetes mellitus. Cochrane Database Syst. Rev. 1, CD006674 (2017).
pubmed: 28046205
The International Weight Management in Pregnancy (i-WIP) Collaborative Group. Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials. BMJ 358, j3119 (2017).
doi: 10.1136/bmj.j3119
Donnelly, J. M., Walsh, J. M., Byrne, J., Molloy, E. J. & McAuliffe, F. M. Impact of maternal diet on neonatal anthropometry: a randomized controlled trial. Pediatr. Obes. 10, 52–56 (2015).
pubmed: 24443392
doi: 10.1111/j.2047-6310.2013.00216.x
Poston, L. et al. Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial. Lancet Diabetes Endocrinol. 3, 767–777 (2015).
pubmed: 26165396
doi: 10.1016/S2213-8587(15)00227-2
Dodd, J. M. et al. The effects of antenatal dietary and lifestyle advice for women who are overweight or obese on maternal diet and physical activity: the LIMIT randomised trial. BMC Med. 12, 161 (2014).
pubmed: 25315237
pmcid: 4194375
doi: 10.1186/s12916-014-0161-y
Patel, N. et al. Infant adiposity following a randomised controlled trial of a behavioural intervention in obese pregnancy. Int. J. Obes. 41, 1018–1026 (2017).
doi: 10.1038/ijo.2017.44
Dodd, J. M. et al. Effects of an antenatal dietary intervention in overweight and obese women on 6 month infant outcomes: follow-up from the LIMIT randomised trial. Int. J. Obes. 42, 1326–1335 (2018).
doi: 10.1038/s41366-018-0019-z
Tanvig, M. Offspring body size and metabolic profile — effects of lifestyle intervention in obese pregnant women. Dan. Med. J. 61, B4893 (2014).
pubmed: 25123127
Catalano, P. & deMouzon, S. H. Maternal obesity and metabolic risk to the offspring: why lifestyle interventions may have not achieved the desired outcomes. Int. J. Obes. 39, 642–649 (2015).
doi: 10.1038/ijo.2015.15
Yeo, S., Walker, J. S., Caughey, M. C., Ferraro, A. M. & Asafu-Adjei, J. K. What characteristics of nutrition and physical activity interventions are key to effectively reducing weight gain in obese or overweight pregnant women? A systematic review and meta-analysis. Obes. Rev. 18, 385–399 (2017).
pubmed: 28177566
doi: 10.1111/obr.12511
Lau, Y. et al. Electronic-based lifestyle interventions in overweight or obese perinatal women: a systematic review and meta-analysis. Obes. Rev. 18, 1071–1087 (2017).
pubmed: 28544551
doi: 10.1111/obr.12557
Gjestland, K., Bo, K., Owe, K. M. & Eberhard-Gran, M. Do pregnant women follow exercise guidelines? Prevalence data among 3482 women, and prediction of low-back pain, pelvic girdle pain and depression. Br. J. Sports Med. 47, 515–520 (2013).
pubmed: 22904295
doi: 10.1136/bjsports-2012-091344
Evenson, K. R., Savitz, D. A. & Huston, S. L. Leisure-time physical activity among pregnant women in the US. Paediatr. Perinat. Epidemiol. 18, 400–407 (2004).
pubmed: 15535815
doi: 10.1111/j.1365-3016.2004.00595.x
Muktabhant, B., Lawrie, T. A., Lumbiganon, P. & Laopaiboon, M. Diet or exercise, or both, for preventing excessive weight gain in pregnancy. Cochrane Database Syst. Rev. 6, CD007145 (2015).
da Silva, S. G., Ricardo, L. I., Evenson, K. R. & Hallal, P. C. Leisure-time physical activity in pregnancy and maternal-child health: a systematic review and meta-analysis of randomized controlled trials and cohort studies. Sports Med. 47, 295–317 (2017).
pubmed: 27282925
doi: 10.1007/s40279-016-0565-2
Tobias, D. K., Zhang, C., van Dam, R. M., Bowers, K. & Hu, F. B. Physical activity before and during pregnancy and risk of gestational diabetes mellitus: a meta-analysis. Diabetes Care 34, 223–229 (2011).
pubmed: 20876206
doi: 10.2337/dc10-1368
Owe, K. M., Nystad, W. & Bo, K. Association between regular exercise and excessive newborn birth weight. Obstet. Gynecol. 114, 770–776 (2009).
pubmed: 19888034
doi: 10.1097/AOG.0b013e3181b6c105
Clapp, J. F. 3rd Morphometric and neurodevelopmental outcome at age five years of the offspring of women who continued to exercise regularly throughout pregnancy. J. Pediatr. 129, 856–863 (1996).
pubmed: 8969727
doi: 10.1016/S0022-3476(96)70029-X
Clapp, J. F. 3rd, Simonian, S., Lopez, B., Appleby-Wineberg, S. & Harcar-Sevcik, R. The one-year morphometric and neurodevelopmental outcome of the offspring of women who continued to exercise regularly throughout pregnancy. Am. J. Obstet. Gynecol. 178, 594–599 (1998).
pubmed: 9539531
doi: 10.1016/S0002-9378(98)70444-2
Mattran, K., Mudd, L. M., Rudey, R. A. & Kelly, J. S. Leisure-time physical activity during pregnancy and offspring size at 18 to 24 months. J. Phys. Act. Health 8, 655–662 (2011).
pubmed: 21734310
doi: 10.1123/jpah.8.5.655
Kong, K. L., Campbell, C., Wagner, K., Peterson, A. & Lanningham-Foster, L. Impact of a walking intervention during pregnancy on post-partum weight retention and infant anthropometric outcomes. J. Dev. Origins Health Dis. 5, 259–267 (2014).
doi: 10.1017/S2040174414000117
Kong, K. L., Gillman, M. W., Rifas-Shiman, S. L. & Wen, X. Leisure time physical activity before and during mid-pregnancy and offspring adiposity in mid-childhood. Pediatr. Obes. 11, 81–87 (2016).
pubmed: 25854785
doi: 10.1111/ijpo.12024
Lupattelli, A. et al. Medication use in pregnancy: a cross-sectional, multinational web-based study. BMJ Open 4, e004365 (2014).
pubmed: 24534260
pmcid: 3927801
doi: 10.1136/bmjopen-2013-004365
Vidal, A. C. et al. Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. Int. J. Obes. 37, 907–913 (2013).
doi: 10.1038/ijo.2013.47
Jepsen, P. et al. A population-based study of maternal use of amoxicillin and pregnancy outcome in Denmark. Br. J. Clin. Pharmacol. 55, 216–221 (2003).
pubmed: 12580995
pmcid: 1894737
doi: 10.1046/j.1365-2125.2003.01750.x
Mor, A. et al. Prenatal exposure to systemic antibacterials and overweight and obesity in Danish schoolchildren: a prevalence study. Int. J. Obes. 39, 1450–1455 (2015).
doi: 10.1038/ijo.2015.129
Azad, M. B., Bridgman, S. L., Becker, A. B. & Kozyrskyj, A. L. Infant antibiotic exposure and the development of childhood overweight and central adiposity. Int. J. Obes. 38, 1290–1298 (2014).
doi: 10.1038/ijo.2014.119
Li, H. T., Zhou, Y. B. & Liu, J. M. The impact of cesarean section on offspring overweight and obesity: a systematic review and meta-analysis. Int. J. Obes. 37, 893–899 (2013).
doi: 10.1038/ijo.2012.195
Yuan, C. et al. Association between cesarean birth and risk of obesity in offspring in childhood, adolescence, and early adulthood. JAMA Pediatr. 170, e162385 (2016).
pubmed: 27599167
pmcid: 5854473
doi: 10.1001/jamapediatrics.2016.2385
Mueller, N. T. et al. Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity. Int. J. Obes. 39, 665–670 (2015).
doi: 10.1038/ijo.2014.180
Dominguez-Bello, M. G. et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc. Natl Acad. Sci. USA 107, 11971–11975 (2010).
pubmed: 20566857
pmcid: 2900693
doi: 10.1073/pnas.1002601107
Jakobsson, H. E. et al. Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section. Gut 63, 559–566 (2014).
pubmed: 23926244
doi: 10.1136/gutjnl-2012-303249
Bouter, K. E., van Raalte, D. H., Groen, A. K. & Nieuwdorp, M. Role of the gut microbiome in the pathogenesis of obesity and obesity-related metabolic dysfunction. Gastroenterology 152, 1671–1678 (2017).
pubmed: 28192102
doi: 10.1053/j.gastro.2016.12.048
Penders, J. et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 118, 511–521 (2006).
pubmed: 16882802
doi: 10.1542/peds.2005-2824
Skilton, M. R. et al. High birth weight is associated with obesity and increased carotid wall thickness in young adults: the cardiovascular risk in young Finns study. Arterioscler. Thromb. Vasc. Biol. 34, 1064–1068 (2014).
pubmed: 24626439
doi: 10.1161/ATVBAHA.113.302934
Singhal, A., Wells, J., Cole, T. J., Fewtrell, M. & Lucas, A. Programming of lean body mass: a link between birth weight, obesity, and cardiovascular disease? Am. J. Clin. Nutr. 77, 726–730 (2003).
pubmed: 12600868
doi: 10.1093/ajcn/77.3.726
Labayen, I. et al. Early programming of body composition and fat distribution in adolescents. J. Nutr. 136, 147–152 (2006).
pubmed: 16365074
doi: 10.1093/jn/136.1.147
Biosca, M. et al. Central adiposity in children born small and large for gestational age. Nutr. Hosp. 26, 971–976 (2011).
pubmed: 22072340
Fonseca, M. J., Severo, M., Correia, S. & Santos, A. C. Effect of birth weight and weight change during the first 96 h of life on childhood body composition—path analysis. Int. J. Obes. 39, 579–585 (2015).
doi: 10.1038/ijo.2015.11
Ejlerskov, K. T. et al. The impact of early growth patterns and infant feeding on body composition at 3 years of age. Br. J. Nutr. 114, 316–327 (2015).
pubmed: 26131962
doi: 10.1017/S0007114515001427
Ali, O. et al. Obesity, central adiposity and cardiometabolic risk factors in children and adolescents: a family-based study. Pediatr. Obes. 9, e58–e62 (2014).
pubmed: 24677702
pmcid: 4114214
doi: 10.1111/j.2047-6310.2014.218.x
Labayen, I. et al. Small birth weight and later body composition and fat distribution in adolescents: the AVENA Study. Obesity 16, 1680–1686 (2008).
pubmed: 18464751
doi: 10.1038/oby.2008.258
Araujo de Franca, G. V., Restrepo-Mendez, M. C., Loret de Mola, C. & Victora, C. G. Size at birth and abdominal adiposity in adults: a systematic review and meta-analysis. Obes. Rev. 15, 77–91 (2014).
pubmed: 24112242
doi: 10.1111/obr.12109
Jaiswal, M. et al. Is low birth weight associated with adiposity in contemporary US youth? The Exploring Perinatal Outcomes among Children (EPOCH) Study. J. Dev. Origins Health Dis. 3, 166–172 (2012).
doi: 10.1017/S2040174412000165
Garnett, S. P. et al. Abdominal fat and birth size in healthy prepubertal children. Int. J. Obes. Relat. Metab. Disord. 25, 1667–1673 (2001).
pubmed: 11753589
doi: 10.1038/sj.ijo.0801821
Dolan, M. S., Sorkin, J. D. & Hoffman, D. J. Birth weight is inversely associated with central adipose tissue in healthy children and adolescents. Obesity 15, 1600–1608 (2007).
pubmed: 17557998
doi: 10.1038/oby.2007.189
Mook-Kanamori, D. O. et al. Fetal and infant growth and the risk of obesity during early childhood: the Generation R Study. Eur. J. Endocrinol. 165, 623–630 (2011).
pubmed: 21775498
doi: 10.1530/EJE-11-0067
Stansfield, B. K. et al. Nonlinear relationship between birth weight and visceral fat in adolescents. J. Pediatr. 174, 185–192 (2016).
pubmed: 27174144
pmcid: 5711485
doi: 10.1016/j.jpeds.2016.04.012
Yu, Z. B. et al. Birth weight and subsequent risk of obesity: a systematic review and meta-analysis. Obes. Rev. 12, 525–542 (2011).
pubmed: 21438992
doi: 10.1111/j.1467-789X.2011.00867.x
Catalano, P. M. & Shankar, K. Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. BMJ 356, j1 (2017).
pubmed: 28179267
pmcid: 6888512
doi: 10.1136/bmj.j1
Whitaker, R. C. Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy. Pediatrics 114, e29–e36 (2004).
pubmed: 15231970
doi: 10.1542/peds.114.1.e29
Arenz, S., Ruckerl, R., Koletzko, B. & von Kries, R. Breast-feeding and childhood obesity—a systematic review. Int. J. Obes. Relat. Metab. Disord. 28, 1247–1256 (2004).
pubmed: 15314625
doi: 10.1038/sj.ijo.0802758
Owen, C. G., Martin, R. M., Whincup, P. H., Smith, G. D. & Cook, D. G. Effect of infant feeding on the risk of obesity across the life course: a quantitative review of published evidence. Pediatrics 115, 1367–1377 (2005).
pubmed: 15867049
doi: 10.1542/peds.2004-1176
Horta, B. L., Loret de Mola, C. & Victora, C. G. Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis. Acta Paediatr. 104, 30–37 (2015).
pubmed: 26192560
doi: 10.1111/apa.13133
Patro-Golab, B. et al. Nutritional interventions or exposures in infants and children aged up to 3 years and their effects on subsequent risk of overweight, obesity and body fat: a systematic review of systematic reviews. Obes. Rev. 17, 1245–1257 (2016).
pubmed: 27749991
pmcid: 5325317
doi: 10.1111/obr.12476
Martin, R. M. et al. Effects of promoting longer-term and exclusive breastfeeding on adiposity and insulin-like growth factor-I at age 11.5 years: a randomized trial. JAMA 309, 1005–1013 (2013).
pubmed: 23483175
pmcid: 3752893
doi: 10.1001/jama.2013.167
Rogers, S. L. & Blissett, J. Breastfeeding duration and its relation to weight gain, eating behaviours and positive maternal feeding practices in infancy. Appetite 108, 399–406 (2017).
pubmed: 27756634
doi: 10.1016/j.appet.2016.10.020
Labayen, I. et al. Breastfeeding attenuates the effect of low birthweight on abdominal adiposity in adolescents: the HELENA study. Matern. Child Nutr. 11, 1036–1040 (2015).
pubmed: 24720543
doi: 10.1111/mcn.12130
Singhal, A. et al. Nutrition in infancy and long-term risk of obesity: evidence from 2 randomized controlled trials. Am. J. Clin. Nutr. 92, 1133–1144 (2010).
pubmed: 20881062
doi: 10.3945/ajcn.2010.29302
Crume, T. L. et al. Long-term impact of neonatal breastfeeding on childhood adiposity and fat distribution among children exposed to diabetes in utero. Diabetes Care 34, 641–645 (2011).
pubmed: 21357361
pmcid: 3041197
doi: 10.2337/dc10-1716
Brion, M. J. et al. What are the causal effects of breastfeeding on IQ, obesity and blood pressure? Evidence from comparing high-income with middle-income cohorts. Int. J. Epidemiol. 40, 670–680 (2011).
pubmed: 21349903
pmcid: 3147072
doi: 10.1093/ije/dyr020
Wang, L., Collins, C., Ratliff, M., Xie, B. & Wang, Y. Breastfeeding reduces childhood obesity risks. Child Obes. 13, 197–204 (2017).
pubmed: 28398851
doi: 10.1089/chi.2016.0210
Patel, R. et al. Cohort profile: the promotion of breastfeeding intervention trial (PROBIT). Int. J. Epidemiol. 43, 679–690 (2014).
pubmed: 23471837
doi: 10.1093/ije/dyt003
Martin, R. M. et al. Effects of promoting long-term, exclusive breastfeeding on adolescent adiposity, blood pressure, and growth trajectories: a secondary analysis of a randomized clinical trial. JAMA Pediatr. 171, e170698 (2017).
pubmed: 28459932
pmcid: 5576545
doi: 10.1001/jamapediatrics.2017.0698
Smithers, L. G., Kramer, M. S. & Lynch, J. W. Effects of breastfeeding on obesity and intelligence: causal insights from different study designs. JAMA Pediatr. 169, 707–708 (2015).
pubmed: 26053565
doi: 10.1001/jamapediatrics.2015.0175
Robinson, S. M. et al. Modifiable early-life risk factors for childhood adiposity and overweight: an analysis of their combined impact and potential for prevention. Am. J. Clin. Nutr. 101, 368–375 (2015).
pubmed: 25646335
doi: 10.3945/ajcn.114.094268
Victora, C. G. et al. Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. Lancet 387, 475–490 (2016).
pubmed: 26869575
doi: 10.1016/S0140-6736(15)01024-7
World Health Organization. Baby-Friendly Hospital Initiative: Revised, Updated and Expanded for Integrated Care (WHO, 2009).
Patro-Golab, B. et al. Protein concentration in milk formula, growth, and later risk of obesity: a systematic review. J. Nutr. 146, 551–564 (2016).
pubmed: 26865649
doi: 10.3945/jn.115.223651
Weber, M. et al. Lower protein content in infant formula reduces BMI and obesity risk at school age: follow-up of a randomized trial. Am. J. Clin. Nutr. 99, 1041–1051 (2014).
pubmed: 24622805
doi: 10.3945/ajcn.113.064071
Putet, G. et al. Effect of dietary protein on plasma insulin-like growth factor-1, growth, and body composition in healthy term infants: a randomised, double-blind, controlled trial (Early Protein and Obesity in Childhood (EPOCH) study. Br. J. Nutr. 115, 271–284 (2016).
pubmed: 26586096
doi: 10.1017/S0007114515004456
Haschke, F. et al. Postnatal high protein intake can contribute to accelerated weight gain of infants and increased obesity risk. Nestle Nutr. Inst. Workshop Series 85, 101–109 (2016).
doi: 10.1159/000439492
Ziegler, E. E. et al. Adequacy of infant formula with protein content of 1.6 g/100 kcal for infants between 3 and 12 months. J. Pediatr. Gastroenterol. Nutr. 61, 596–603 (2015).
pubmed: 26154030
doi: 10.1097/MPG.0000000000000881
Socha, P. et al. Milk protein intake, the metabolic-endocrine response, and growth in infancy: data from a randomized clinical trial. Am. J. Clin. Nutr. 94, 1776S–1784S (2011).
pubmed: 21849603
doi: 10.3945/ajcn.110.000596
Rolland-Cachera, M. F. et al. Adiposity rebound in children: a simple indicator for predicting obesity. Am. J. Clin. Nutr. 39, 129–135 (1984).
pubmed: 6691287
doi: 10.1093/ajcn/39.1.129
Hellmuth, C. et al. Effects of early nutrition on the infant metabolome. Nestle Nutr. Inst. Workshop Series 85, 89–100 (2016).
doi: 10.1159/000439491
Ong, K. K. & Loos, R. J. Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr. 95, 904–908 (2006).
pubmed: 16882560
doi: 10.1080/08035250600719754
Druet, C. et al. Prediction of childhood obesity by infancy weight gain: an individual-level meta-analysis. Paediatr. Perinat. Epidemiol. 26, 19–26 (2012).
pubmed: 22150704
doi: 10.1111/j.1365-3016.2011.01213.x
Wells, J. C., Chomtho, S. & Fewtrell, M. S. Programming of body composition by early growth and nutrition. Proc. Nutr. Soc. 66, 423–434 (2007).
pubmed: 17637095
doi: 10.1017/S0029665107005691
Adair, L. S. et al. Size at birth, weight gain in infancy and childhood, and adult blood pressure in 5 low- and middle-income-country cohorts: when does weight gain matter? Am. J. Clin. Nutr. 89, 1383–1392 (2009).
pubmed: 19297457
pmcid: 2720838
doi: 10.3945/ajcn.2008.27139
Corvalan, C., Gregory, C. O., Ramirez-Zea, M., Martorell, R. & Stein, A. D. Size at birth, infant, early and later childhood growth and adult body composition: a prospective study in a stunted population. Int. J. Epidemiol. 36, 550–557 (2007).
pubmed: 17376801
doi: 10.1093/ije/dym010
Gonzalez, D. A., Nazmi, A. & Victora, C. G. Growth from birth to adulthood and abdominal obesity in a Brazilian birth cohort. Int. J. Obes. 34, 195–202 (2010).
doi: 10.1038/ijo.2009.201
Wells, J. C., Hallal, P. C., Wright, A., Singhal, A. & Victora, C. G. Fetal, infant and childhood growth: relationships with body composition in Brazilian boys aged 9 years. Int. J. Obes. 29, 1192–1198 (2005).
doi: 10.1038/sj.ijo.0803054
Sachdev, H. S. et al. Anthropometric indicators of body composition in young adults: relation to size at birth and serial measurements of body mass index in childhood in the New Delhi birth cohort. Am. J. Clin. Nutr. 82, 456–466 (2005).
pubmed: 16087993
doi: 10.1093/ajcn/82.2.456
Baird, J. et al. Being big or growing fast: systematic review of size and growth in infancy and later obesity. BMJ 331, 929 (2005).
pubmed: 16227306
pmcid: 1261184
doi: 10.1136/bmj.38586.411273.E0
Monteiro, P. O. & Victora, C. G. Rapid growth in infancy and childhood and obesity in later life — a systematic review. Obes. Rev. 6, 143–154 (2005).
pubmed: 15836465
doi: 10.1111/j.1467-789X.2005.00183.x
Iguacel, I. et al. Early life risk factors and their cumulative effects as predictors of overweight in Spanish children. Int. J. Public Health 63, 501–512 (2018).
pubmed: 29549397
doi: 10.1007/s00038-018-1090-x
Kwon, S., Janz, K. F., Letuchy, E. M., Burns, T. L. & Levy, S. M. Association between body mass index percentile trajectories in infancy and adiposity in childhood and early adulthood. Obesity 25, 166–171 (2017).
pubmed: 27804242
doi: 10.1002/oby.21673
Chomtho, S. et al. Infant growth and later body composition: evidence from the 4-component model. Am. J. Clin. Nutr. 87, 1776–1784 (2008).
pubmed: 18541568
doi: 10.1093/ajcn/87.6.1776
Koontz, M. B., Gunzler, D. D., Presley, L. & Catalano, P. M. Longitudinal changes in infant body composition: association with childhood obesity. Pediatr. Obes. 9, e141–e144 (2014).
pubmed: 25267097
pmcid: 4702488
doi: 10.1111/ijpo.253
Hong, Y. H. & Chung, S. Small for gestational age and obesity related comorbidities. Ann. Pediatr. Endocrinol. Metab. 23, 4–8 (2018).
pubmed: 29609443
pmcid: 5894558
doi: 10.6065/apem.2018.23.1.4
Lei, X. et al. The optimal postnatal growth trajectory for term small for gestational age babies: a prospective cohort study. J. Pediatr. 166, 54–58 (2015).
pubmed: 25444014
doi: 10.1016/j.jpeds.2014.09.025
Mo-Suwan, L., McNeil, E., Sangsupawanich, P., Chittchang, U. & Choprapawon, C. Adiposity rebound from three to six years of age was associated with a higher insulin resistance risk at eight-and-a-half years in a birth cohort study. Acta Paediatr. 106, 128–134 (2017).
pubmed: 27759899
doi: 10.1111/apa.13639
Arisaka, O., Sairenchi, T., Ichikawa, G. & Koyama, S. Increase of body mass index (BMI) from 1.5 to 3 years of age augments the degree of insulin resistance corresponding to BMI at 12 years of age. J. Pediatr. Endocrinol. Metab. 30, 455–457 (2017).
pubmed: 28306535
doi: 10.1515/jpem-2016-0227
Gunther, A. L., Buyken, A. E. & Kroke, A. Protein intake during the period of complementary feeding and early childhood and the association with body mass index and percentage body fat at 7 y of age. Am. J. Clin. Nutr. 85, 1626–1633 (2007).
pubmed: 17556702
doi: 10.1093/ajcn/85.6.1626
Hoppe, C., Molgaard, C., Thomsen, B. L., Juul, A. & Michaelsen, K. F. Protein intake at 9 mo of age is associated with body size but not with body fat in 10-y-old Danish children. Am. J. Clin. Nutr. 79, 494–501 (2004).
pubmed: 14985227
doi: 10.1093/ajcn/79.3.494
Pimpin, L., Jebb, S., Johnson, L., Wardle, J. & Ambrosini, G. L. Dietary protein intake is associated with body mass index and weight up to 5 y of age in a prospective cohort of twins. Am. J. Clin. Nutr. 103, 389–397 (2016).
pubmed: 26718416
doi: 10.3945/ajcn.115.118612
Voortman, T. et al. Protein intake in early childhood and body composition at the age of 6 years: the Generation R Study. Int. J. Obes. 40, 1018–1025 (2016).
doi: 10.1038/ijo.2016.29
Food and Agriculture Organization of the United Nations, World Health Organization & United Nations University. Energy and protein requirements. Report of a joint FAO/WHO/UNU Expert Consultation. World Health Organ. Tech. Rep. Ser. 724, 1–206 (1985).
Michaelsen, K. F., Weaver, L., Branca, F. & Robertson, A. (eds) Feeding and Nutrition of Infants and Young Children (WHO, 2000).
Naude, C. E., Visser, M. E., Nguyen, K. A., Durao, S. & Schoonees, A. Effects of total fat intake on bodyweight in children. Cochrane Database Syst. Rev. 7, CD012960 (2018).
pubmed: 29974953
Skinner, J. D., Bounds, W., Carruth, B. R., Morris, M. & Ziegler, P. Predictors of children’s body mass index: a longitudinal study of diet and growth in children aged 2–8 y. Int. J. Obes. Relat. Metab. Disord. 28, 476–482 (2004).
pubmed: 14993908
doi: 10.1038/sj.ijo.0802405
Rolland-Cachera, M. F. et al. Association of nutrition in early life with body fat and serum leptin at adult age. Int. J. Obes. 37, 1116–1122 (2013).
doi: 10.1038/ijo.2012.185
Heppe, D. H. et al. Parental, fetal, and infant risk factors for preschool overweight: the Generation R Study. Pediatr. Res. 73, 120–127 (2013).
pubmed: 23138398
doi: 10.1038/pr.2012.145
Stroobant, W. et al. Intake of different types of fatty acids in infancy is not associated with growth, adiposity, or cardiometabolic health up to 6 years of age. J. Nutr. 147, 413–420 (2017).
pubmed: 28122928
Agostoni, C. et al. Dietary fats and cholesterol in Italian infants and children. Am. J. Clin. Nutr. 72, 1384S–1391S (2000).
pubmed: 11063482
doi: 10.1093/ajcn/72.5.1384s
Hakanen, M. et al. Development of overweight in an atherosclerosis prevention trial starting in early childhood. The STRIP study. Int. J. Obes. 30, 618–626 (2006).
doi: 10.1038/sj.ijo.0803249
World Health Organization. Guideline: Sugars Intake for Adults and Children (WHO, 2015).
Bresson, J.-L. et al. Review of labelling reference intake values. Scientific opinion of the panel on dietetic products, nutrition and allergies on a request from the commission related to the review of labelling reference intake values for selected nutritional elements. EFSA J. 1008, 1–14 (2009).
Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (National Academies Press, 2005).
Fidler Mis, N. et al. Sugar in infants, children and adolescents: a position paper of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J. Pediatr. Gastroenterol. Nutr. 65, 681–696 (2017).
pubmed: 28922262
doi: 10.1097/MPG.0000000000001733
Vos, M. B. et al. Added sugars and cardiovascular disease risk in children: a scientific statement from the American Heart Association. Circulation 135, e1017–e1034 (2017).
pubmed: 27550974
doi: 10.1161/CIR.0000000000000439
Newens, K. J. & Walton, J. A review of sugar consumption from nationally representative dietary surveys across the world. J. Hum. Nutr. Diet 29, 225–240 (2016).
pubmed: 26453428
doi: 10.1111/jhn.12338
Herbst, A. et al. Direction of associations between added sugar intake in early childhood and body mass index at age 7 years may depend on intake levels. J. Nutr. 141, 1348–1354 (2011).
pubmed: 21562234
doi: 10.3945/jn.110.137000
Pan, L. et al. A longitudinal analysis of sugar-sweetened beverage intake in infancy and obesity at 6 years. Pediatrics 134 (Suppl. 1), 29–35 (2014).
doi: 10.1542/peds.2014-0646F
Cantoral, A. et al. Early introduction and cumulative consumption of sugar-sweetened beverages during the pre-school period and risk of obesity at 8–14 years of age. Pediatr. Obes. 11, 68–74 (2016).
pubmed: 25891908
doi: 10.1111/ijpo.12023
Sonneville, K. R. et al. Juice and water intake in infancy and later beverage intake and adiposity: could juice be a gateway drink? Obesity 23, 170–176 (2015).
pubmed: 25328160
doi: 10.1002/oby.20927
Liem, D. G. & Mennella, J. A. Sweet and sour preferences during childhood: role of early experiences. Dev. Psychobiol. 41, 388–395 (2002).
pubmed: 12430162
pmcid: 2784884
doi: 10.1002/dev.10067
Walker, R. W. & Goran, M. I. Laboratory determined sugar content and composition of commercial infant formulas, baby foods and common grocery items targeted to children. Nutrients 7, 5850–5867 (2015).
pubmed: 26193309
pmcid: 4517031
doi: 10.3390/nu7075254
Koletzko, B. et al. Pureed fruit pouches for babies: child health under squeeze. J. Pediatr. Gastroenterol. Nutr. 67, 561–563 (2018).
pubmed: 29901550
doi: 10.1097/MPG.0000000000002061
Parnell, J. A. & Reimer, R. A. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am. J. Clin. Nutr. 89, 1751–1759 (2009).
pubmed: 19386741
doi: 10.3945/ajcn.2009.27465
Hume, M. P., Nicolucci, A. C. & Reimer, R. A. Prebiotic supplementation improves appetite control in children with overweight and obesity: a randomized controlled trial. Am. J. Clin. Nutr. 105, 790–799 (2017).
pubmed: 28228425
doi: 10.3945/ajcn.116.140947
Cani, P. D., Joly, E., Horsmans, Y. & Delzenne, N. M. Oligofructose promotes satiety in healthy human: a pilot study. Eur. J. Clin. Nutr. 60, 567–572 (2006).
pubmed: 16340949
doi: 10.1038/sj.ejcn.1602350
Liber, A. & Szajewska, H. Effect of oligofructose supplementation on body weight in overweight and obese children: a randomised, double-blind, placebo-controlled trial. Br. J. Nutr. 112, 2068–2074 (2014).
pubmed: 25327394
doi: 10.1017/S0007114514003110
Bomhof, M. R., Saha, D. C., Reid, D. T., Paul, H. A. & Reimer, R. A. Combined effects of oligofructose and Bifidobacterium animalis on gut microbiota and glycemia in obese rats. Obesity 22, 763–771 (2014).
pubmed: 24124012
doi: 10.1002/oby.20632
Agostoni, C. et al. Complementary feeding: a commentary by the ESPGHAN Committee on Nutrition. J. Pediatr. Gastroenterol. Nutr. 46, 99–110 (2008).
pubmed: 18162844
doi: 10.1097/01.mpg.0000304464.60788.bd
World Health Organization. The Optimal Duration of Exclusive Breastfeeding: Report of an Expert Consultation (WHO, 2001).
Guandalini, S. Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. J. Pediatr. Gastroenterol. Nutr. 41, 366–367 (2005).
pubmed: 16131999
doi: 10.1097/01.mpg.0000177313.88694.e5
Pearce, J., Taylor, M. A. & Langley-Evans, S. C. Timing of the introduction of complementary feeding and risk of childhood obesity: a systematic review. Int. J. Obes. 37, 1295–1306 (2013).
doi: 10.1038/ijo.2013.99
Michaelsen, K. F., Larnkjaer, A., Larsson, M. W. & Molgaard, C. Early nutrition and its effects on growth, body composition and later obesity. World Rev. Nutr. Diet. 114, 103–119 (2016).
pubmed: 26906608
doi: 10.1159/000441820
Shalitin, S., Battelino, T. & Moreno, L. A. Obesity, metabolic syndrome and nutrition. World Rev. Nutr. Diet. 114, 21–49 (2016).
pubmed: 26906026
doi: 10.1159/000441810
Collings, P. J. et al. Sleep duration and adiposity in early childhood: evidence for bidirectional associations from the born in Bradford Study. Sleep 40, zsw054 (2017).
doi: 10.1093/sleep/zsw054
Baird, J. et al. Duration of sleep at 3 years of age is associated with fat and fat-free mass at 4 years of age: the Southampton Women’s Survey. J. Sleep Res. 25, 412–418 (2016).
pubmed: 26909889
pmcid: 4979987
doi: 10.1111/jsr.12389
Cespedes, E. M. et al. Chronic insufficient sleep and diet quality: contributors to childhood obesity. Obesity 24, 184–190 (2016).
pubmed: 26592489
doi: 10.1002/oby.21196
Taveras, E. M., Gillman, M. W., Pena, M. M., Redline, S. & Rifas-Shiman, S. L. Chronic sleep curtailment and adiposity. Pediatrics 133, 1013–1022 (2014).
pubmed: 24843068
pmcid: 4035591
doi: 10.1542/peds.2013-3065
Bornhorst, C. et al. From sleep duration to childhood obesity—what are the pathways? Eur. J. Pediatr. 171, 1029–1038 (2012).
pubmed: 22237400
doi: 10.1007/s00431-011-1670-8
Diethelm, K., Bolzenius, K., Cheng, G., Remer, T. & Buyken, A. E. Longitudinal associations between reported sleep duration in early childhood and the development of body mass index, fat mass index and fat free mass index until age 7. Int. J. Pediatr. Obes. 6, e114–e123 (2011).
pubmed: 21604964
doi: 10.3109/17477166.2011.566338
Reilly, J. J. et al. Early life risk factors for obesity in childhood: cohort study. BMJ 330, 1357 (2005).
pubmed: 15908441
pmcid: 558282
doi: 10.1136/bmj.38470.670903.E0
Paruthi, S. et al. Recommended amount of sleep for pediatric populations: a consensus statement of the American Academy of Sleep Medicine. J. Clin. Sleep Med. 12, 785–786 (2016).
pubmed: 27250809
pmcid: 4877308
doi: 10.5664/jcsm.5866
Wake, M., Price, A., Clifford, S., Ukoumunne, O. C. & Hiscock, H. Does an intervention that improves infant sleep also improve overweight at age 6? Follow-up of a randomised trial. Arch. Dis. Child 96, 526–532 (2011).
pubmed: 21402578
doi: 10.1136/adc.2010.196832
Duch, H., Fisher, E. M., Ensari, I. & Harrington, A. Screen time use in children under 3 years old: a systematic review of correlates. Int. J. Behav. Nutr. Phys. Act. 10, 102 (2013).
pubmed: 23967799
pmcid: 3844496
doi: 10.1186/1479-5868-10-102
Poitras, V. J. et al. Systematic review of the relationships between sedentary behaviour and health indicators in the early years (0–4 years). BMC Public Health 17, 868 (2017).
pubmed: 29219092
pmcid: 5773886
doi: 10.1186/s12889-017-4849-8
Manios, Y. et al. Television viewing and food habits in toddlers and preschoolers in Greece: the GENESIS study. Eur. J. Pediatr. 168, 801–808 (2009).
pubmed: 18836742
doi: 10.1007/s00431-008-0838-3
Brown, A. Media use by children younger than 2 years. Pediatrics 128, 1040–1045 (2011).
pubmed: 22007002
doi: 10.1542/peds.2011-1753
American Academy of Pediatrics. American Academy of Pediatrics announces new recommendations for children’s media use. AAP https://www.aap.org/en-us/about-the-aap/aap-press-room/pages/american-academy-of-pediatrics-announces-new-recommendations-for-childrens-media-use.aspx (2016).
Viner, R. M. & Cole, T. J. Television viewing in early childhood predicts adult body mass index. J. Pediatr. 147, 429–435 (2005).
Godfrey, K. M. et al. Influence of maternal obesity on the long-term health of offspring. Lancet Diabetes Endocrinol. 5, 53–64 (2017).
pubmed: 27743978
doi: 10.1016/S2213-8587(16)30107-3
World Health Organization. WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience (WHO, 2016).
Tirado, M. C. et al. Mapping of nutrition and sectoral policies addressing malnutrition in Latin America. Rev. Panam. Salud Publica 40, 114–123 (2016).
pubmed: 27982369
McCloskey, K. et al. The association between higher maternal pre-pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn. Pediatr. Obes. 13, 46–53 (2016).
pubmed: 27723247
doi: 10.1111/ijpo.12187
Linares, J. et al. The effects of pre-pregnancy BMI and maternal factors on the timing of adiposity rebound in offspring. Obesity 24, 1313–1319 (2016).
pubmed: 27086475
doi: 10.1002/oby.21490
Daraki, V. et al. Metabolic profile in early pregnancy is associated with offspring adiposity at 4 years of age: the Rhea pregnancy cohort Crete, Greece. PLOS ONE 10, e0126327 (2015).
pubmed: 25970502
pmcid: 4430416
doi: 10.1371/journal.pone.0126327
Leonard, S. A., Petito, L. C., Rehkopf, D. H., Ritchie, L. D. & Abrams, B. Weight gain in pregnancy and child weight status from birth to adulthood in the United States. Pediatr. Obes. 12, S18–S25 (2016).
doi: 10.1111/ijpo.12163
Tan, H. C. et al. Mother’s pre-pregnancy BMI is an important determinant of adverse cardiometabolic risk in childhood. Pediatr. Diabetes 16, 419–426 (2015).
pubmed: 25800542
pmcid: 4534350
doi: 10.1111/pedi.12273
Aris, I. M. et al. Associations of gestational glycemia and prepregnancy adiposity with offspring growth and adiposity in an Asian population. Am. J. Clin. Nutr. 102, 1104–1112 (2015).
pubmed: 26423388
doi: 10.3945/ajcn.115.117614
Gademan, M. G. et al. Maternal prepregnancy BMI and lipid profile during early pregnancy are independently associated with offspring’s body composition at age 5–6 years: the ABCD study. PLOS ONE 9, e94594 (2014).
pubmed: 24740157
pmcid: 3989215
doi: 10.1371/journal.pone.0094594
Perng, W., Gillman, M. W., Mantzoros, C. S. & Oken, E. A prospective study of maternal prenatal weight and offspring cardiometabolic health in midchildhood. Ann. Epidemiol. 24, 793–800 (2014).
pubmed: 25263237
pmcid: 4254266
doi: 10.1016/j.annepidem.2014.08.002
Li, N. et al. Maternal prepregnancy body mass index and gestational weight gain on offspring overweight in early infancy. PLOS ONE 8, e77809 (2013).
pubmed: 24204979
pmcid: 3817352
doi: 10.1371/journal.pone.0077809
Chandler-Laney, P. C., Gower, B. A. & Fields, D. A. Gestational and early life influences on infant body composition at 1 year. Obesity 21, 144–148 (2013).
pubmed: 23505179
doi: 10.1002/oby.20236
Wright, C. M., Emmett, P. M., Ness, A. R., Reilly, J. J. & Sherriff, A. Tracking of obesity and body fatness through mid-childhood. Arch. Dis. Child 95, 612–617 (2010).
pubmed: 20522467
doi: 10.1136/adc.2009.164491
Tanvig, M. et al. Pregestational body mass index is related to neonatal abdominal circumference at birth—a Danish population-based study. BJOG 120, 320–330 (2013).
pubmed: 23146023
doi: 10.1111/1471-0528.12062
Kaar, J. L. et al. Maternal obesity, gestational weight gain, and offspring adiposity: the exploring perinatal outcomes among children study. J. Pediatr. 165, 509–515 (2014).
pubmed: 24996985
pmcid: 4145019
doi: 10.1016/j.jpeds.2014.05.050
Alberico, S. et al. The role of gestational diabetes, pre-pregnancy body mass index and gestational weight gain on the risk of newborn macrosomia: results from a prospective multicentre study. BMC Pregnancy Childbirth 14, 23 (2014).
pubmed: 24428895
pmcid: 3898774
doi: 10.1186/1471-2393-14-23
Ziyab, A. H., Karmaus, W., Kurukulaaratchy, R. J., Zhang, H. & Arshad, S. H. Developmental trajectories of body mass index from infancy to 18 years of age: prenatal determinants and health consequences. J. Epidemiol. Commun. Health 68, 934–941 (2014).
doi: 10.1136/jech-2014-203808
Ensenauer, R. et al. Effects of suboptimal or excessive gestational weight gain on childhood overweight and abdominal adiposity: results from a retrospective cohort study. Int. J. Obes. 37, 505–512 (2013).
doi: 10.1038/ijo.2012.226
Ode, K. L., Gray, H. L., Ramel, S. E., Georgieff, M. K. & Demerath, E. W. Decelerated early growth in infants of overweight and obese mothers. J. Pediatr. 161, 1028–1034 (2012).
pubmed: 22819273
pmcid: 3480982
doi: 10.1016/j.jpeds.2012.06.001
Stuebe, A. M. et al. Maternal BMI, glucose tolerance, and adverse pregnancy outcomes. Am. J. Obstet. Gynecol. 207, 62.e1–62.e7 (2012).
doi: 10.1016/j.ajog.2012.04.035
Lindberg, S. M., Adams, A. K. & Prince, R. J. Early predictors of obesity and cardiovascular risk among American Indian children. Matern. Child Health J. 16, 1879–1886 (2012).
pubmed: 22527771
pmcid: 3438386
doi: 10.1007/s10995-012-1024-9
Fraser, A. et al. Association of maternal weight gain in pregnancy with offspring obesity and metabolic and vascular traits in childhood. Circulation 121, 2557–2564 (2010).
pubmed: 20516377
pmcid: 3505019
doi: 10.1161/CIRCULATIONAHA.109.906081
Crozier, S. R. et al. Weight gain in pregnancy and childhood body composition: findings from the Southampton Women’s Survey. Am. J. Clin. Nutr. 91, 1745–1751 (2010).
pubmed: 20375187
doi: 10.3945/ajcn.2009.29128
Schack-Nielsen, L., Michaelsen, K. F., Gamborg, M., Mortensen, E. L. & Sorensen, T. I. Gestational weight gain in relation to offspring body mass index and obesity from infancy through adulthood. Int. J. Obes. 34, 67–74 (2010).
doi: 10.1038/ijo.2009.206
Lawlor, D. A. et al. Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable. PLOS Med. 5, e33 (2008).
pubmed: 18336062
pmcid: 2265763
doi: 10.1371/journal.pmed.0050033
Oken, E., Rifas-Shiman, S. L., Field, A. E., Frazier, A. L. & Gillman, M. W. Maternal gestational weight gain and offspring weight in adolescence. Obstet. Gynecol. 112, 999–1006 (2008).
pubmed: 18978098
pmcid: 3001295
doi: 10.1097/AOG.0b013e31818a5d50
Gale, C. R. et al. Maternal size in pregnancy and body composition in children. J. Clin. Endocrinol. Metab. 92, 3904–3911 (2007).
pubmed: 17684051
doi: 10.1210/jc.2007-0088
Oken, E., Taveras, E. M., Kleinman, K. P., Rich-Edwards, J. W. & Gillman, M. W. Gestational weight gain and child adiposity at age 3 years. Am. J. Obstet. Gynecol. 196, 322.e1–322.e8 (2007).
doi: 10.1016/j.ajog.2006.11.027
Labayen, I. et al. Intergenerational cardiovascular disease risk factors involve both maternal and paternal BMI. Diabetes Care 33, 894–900 (2010).
pubmed: 20056951
pmcid: 2845048
doi: 10.2337/dc09-1878
Durmus, B. et al. Growth in foetal life and infancy is associated with abdominal adiposity at the age of 2 years: the generation R study. Clin. Endocrinol. 72, 633–640 (2010).
doi: 10.1111/j.1365-2265.2009.03708.x
Kensara, O. A. et al. Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy X-ray absorptiometry and anthropometric methods in older Englishmen. Am. J. Clin. Nutr. 82, 980–987 (2005).
pubmed: 16280428
doi: 10.1093/ajcn/82.5.980
McNeely, M. J., Fujimoto, W. Y., Leonetti, D. L., Tsai, E. C. & Boyko, E. J. The association between birth weight and visceral fat in middle-age adults. Obesity 15, 816–819 (2007).
pubmed: 17426314
doi: 10.1038/oby.2007.596
Demerath, E. W. et al. Rapid postnatal weight gain and visceral adiposity in adulthood: the Fels Longitudinal Study. Obesity 17, 2060–2066 (2009).
pubmed: 19373221
doi: 10.1038/oby.2009.105
Rolfe Ede, L. et al. Association between birth weight and visceral fat in adults. Am. J. Clin. Nutr. 92, 347–352 (2010).
pubmed: 20519560
doi: 10.3945/ajcn.2010.29247
Pilgaard, K. et al. Differential nongenetic impact of birth weight versus third-trimester growth velocity on glucose metabolism and magnetic resonance imaging abdominal obesity in young healthy twins. J. Clin. Endocrinol. Metab. 96, 2835–2843 (2011).
pubmed: 21733994
doi: 10.1210/jc.2011-0577
Ronn, P. F. et al. Birth weight and risk of adiposity among adult Inuit in Greenland. PLOS ONE 9, e115976 (2014).
pubmed: 25551382
pmcid: 4281098
doi: 10.1371/journal.pone.0115976
Araujo de Franca, G. V. et al. Associations of birth weight, linear growth and relative weight gain throughout life with abdominal fat depots in adulthood: the 1982 Pelotas (Brazil) birth cohort study. Int. J. Obes. 40, 14–21 (2016).
pubmed: 26395747
doi: 10.1038/ijo.2015.192