Protein Translation and Psychiatric Disorders.
addiction
bipolar disorder
mRNA translation
major depressive disorder
protein translation
psychiatric disorders
schizophrenia
Journal
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
ISSN: 1089-4098
Titre abrégé: Neuroscientist
Pays: United States
ID NLM: 9504819
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
pubmed:
5
7
2019
medline:
9
6
2021
entrez:
5
7
2019
Statut:
ppublish
Résumé
Although historically research has focused on transcription as the central governor of protein expression, protein translation is now increasingly being recognized as a major factor for determining protein levels within cells. The central nervous system relies on efficient updating of the protein landscape. Thus, coordinated regulation of mRNA localization, initiation, or termination of translation is essential for proper brain function. In particular, dendritic protein synthesis plays a key role in synaptic plasticity underlying learning and memory as well as cognitive processes. Increasing evidence suggests that impaired mRNA translation is a common feature found in numerous psychiatric disorders. In this review, we describe how malfunction of translation contributes to development of psychiatric diseases, including schizophrenia, major depression, bipolar disorder, and addiction.
Identifiants
pubmed: 31271100
doi: 10.1177/1073858419853236
pmc: PMC7255087
mid: NIHMS1589898
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
21-42Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA027474
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA023489
Pays : United States
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