Neuropeptides at the crossroad of fear and hunger: a special focus on neuropeptide Y.
NPY
anxiety
fear
feeding
hunger
neuropeptide Y
neuropeptides
Journal
Annals of the New York Academy of Sciences
ISSN: 1749-6632
Titre abrégé: Ann N Y Acad Sci
Pays: United States
ID NLM: 7506858
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
29
01
2019
revised:
15
05
2019
accepted:
03
06
2019
pubmed:
5
7
2019
medline:
6
5
2020
entrez:
5
7
2019
Statut:
ppublish
Résumé
Survival in a natural environment forces an individual into constantly adapting purposive behavior. Specified interoceptive neurons monitor metabolic and physiological balance and activate dedicated brain circuits to satisfy essential needs, such as hunger, thirst, thermoregulation, fear, or anxiety. Neuropeptides are multifaceted, central components within such life-sustaining programs. For instance, nutritional depletion results in a drop in glucose levels, release of hormones, and activation of hypothalamic and brainstem neurons. These neurons, in turn, release several neuropeptides that increase food-seeking behavior and promote food intake. Similarly, internal and external threats activate neuronal pathways of avoidance and defensive behavior. Interestingly, specific nuclei of the hypothalamus and extended amygdala are activated by both hunger and fear. Here, we introduce the relevant neuropeptides and describe their function in feeding and emotional-affective behaviors. We further highlight specific pathways and microcircuits, where neuropeptides may interact to identify prevailing homeostatic needs and direct respective compensatory behaviors. A specific focus will be on neuropeptide Y, since it is known for its pivotal role in metabolic and emotional pathways. We hypothesize that the orexigenic and anorexigenic properties of specific neuropeptides are related to their ability to inhibit fear and anxiety.
Identifiants
pubmed: 31271235
doi: 10.1111/nyas.14179
pmc: PMC6899945
doi:
Substances chimiques
Ghrelin
0
Leptin
0
Neuropeptide Y
0
Melanocyte-Stimulating Hormones
9002-79-3
Cholecystokinin
9011-97-6
Corticotropin-Releasing Hormone
9015-71-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
59-80Informations de copyright
© 2019 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals, Inc. on behalf of New York Academy of Sciences.
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