Origanum vulgare L. essential oil inhibits the growth of carbapenem-resistant gram-negative bacteria.
Acinetobacter baumannii
/ drug effects
Anti-Bacterial Agents
/ classification
Bacterial Proteins
Carbapenems
/ pharmacology
Drug Resistance, Multiple, Bacterial
Gram-Negative Bacteria
/ drug effects
Humans
Klebsiella pneumoniae
/ drug effects
Microbial Sensitivity Tests
Oils, Volatile
/ pharmacology
Origanum
/ chemistry
Serratia marcescens
/ drug effects
beta-Lactamases
Journal
Revista da Sociedade Brasileira de Medicina Tropical
ISSN: 1678-9849
Titre abrégé: Rev Soc Bras Med Trop
Pays: Brazil
ID NLM: 7507456
Informations de publication
Date de publication:
27 Jun 2019
27 Jun 2019
Historique:
received:
21
11
2018
accepted:
16
04
2019
entrez:
5
7
2019
pubmed:
5
7
2019
medline:
28
7
2019
Statut:
epublish
Résumé
Plant products are sources for drug development against multidrug resistant bacteria. The antimicrobial activity of Origanum vulgare L. essential oil (OVeo) against carbapenem-resistant strains was assessed by disk-diffusion, microdilution (REMA-Resazurin Microtiter Assay), and time kill assays. Carbapenemase production was confirmed for all strains. OVeo exhibited a minimum inhibitory concentration of 0.059% v/v for Klebsiella pneumoniae and Serratia marcescens, and of 0.015 % v/v for Acinetobacter baumannii. A decrease in cell count was observed after a 4 h treatment. OVeo antimicrobial effect was rapid and consistent, making it a candidate for developing alternative therapeutic options against carbapenem-resistant strains.
Identifiants
pubmed: 31271619
pii: S0037-86822019000100670
doi: 10.1590/0037-8682-0502-2018
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Carbapenems
0
Oils, Volatile
0
beta-Lactamases
EC 3.5.2.6
carbapenemase
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng