Preoperative radiotherapy: A paradigm shift in the treatment of breast cancer? A review of literature.
Breast cancer
Local control
Neoadjuvant treatment
Outcome
Preoperative radiotherapy
Radiotherapy
Survival
pCR
Journal
Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
07
02
2019
revised:
12
05
2019
accepted:
03
06
2019
pubmed:
5
7
2019
medline:
18
10
2019
entrez:
5
7
2019
Statut:
ppublish
Résumé
The standard of care for early-stage breast cancer (BC) consists of breast-conserving surgery followed by postoperative irradiation. Recently, the concept of changing the usual sequence of treatment components in BC RT has been investigated. Potential advantages of preoperative RT in BC include a possible tumor downstaging with improved surgical cosmetic outcomes, accurate tumor site identification and better target volume delineation. Furthermore, preoperative RT could serve as a tool for treatment stratification for de-escalation of treatments in the event of pathological complete response. The present literature review analyzed the available clinical data regarding the potential impact of preoperative RT. Overall, available clinical evidence of preoperative RT in BC remains limited, deriving mostly from retrospective case series. Nevertheless, the experiences prove the feasibility of the preoperative RT approach and confirm the efficacy in almost all analyzed studies, including experiences using higher prescription RT doses or RT in combination with systemic therapy.
Identifiants
pubmed: 31272045
pii: S1040-8428(19)30111-8
doi: 10.1016/j.critrevonc.2019.06.003
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102-111Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.