Effects of Iliac Stenosis on Abdominal Aortic Aneurysm Formation in Mice and Humans.
Animals
Aortic Aneurysm, Abdominal
/ diagnostic imaging
Arterial Occlusive Diseases
/ complications
Blood Flow Velocity
Case-Control Studies
Constriction, Pathologic
Disease Models, Animal
Disease Progression
Humans
Iliac Artery
/ diagnostic imaging
Interleukin-6
/ metabolism
Male
Mice, Inbred C57BL
Pancreatic Elastase
Regional Blood Flow
Risk Factors
Time Factors
Transforming Growth Factor beta1
/ metabolism
Vascular Endothelial Growth Factor A
/ metabolism
Aneurysm
Asymmetry
Iliac artery
Murine
Journal
Journal of vascular research
ISSN: 1423-0135
Titre abrégé: J Vasc Res
Pays: Switzerland
ID NLM: 9206092
Informations de publication
Date de publication:
2019
2019
Historique:
received:
14
02
2019
accepted:
04
06
2019
pubmed:
5
7
2019
medline:
28
1
2020
entrez:
5
7
2019
Statut:
ppublish
Résumé
Reduced lower-limb blood flow has been shown to lead to asymmetrical abdominal aortic aneurysms (AAAs) but the mechanism of action is not fully understood. Therefore, small animal ultrasound (Vevo2100, FUJIFILM VisualSonics) was used to longitudinally study mice that underwent standard porcine pancreatic elastase (PPE) infusion (n = 5), and PPE infusion with modified 20% iliac artery stenosis in the left (n = 4) and right (n = 5) iliac arteries. Human AAA computed tomography images were obtained from patients with normal (n = 9) or stenosed left (n = 2), right (n = 1), and bilateral (n = 1) iliac arteries. We observed rapid early growth and rightward expansion (8/9 mice) in the modified PPE groups (p < 0.05), leading to slightly larger and asymmetric AAAs compared to the standard PPE group. Further examination showed a significant increase in TGFβ1 (p < 0.05) and cellular infiltration (p < 0.05) in the modified PPE group versus standard PPE mice. Congruent, yet variable, observations were made in human AAA patients with reduced iliac outflow compared to those with normal iliac outflow. Our results suggest that arterial stenosis at the time of aneurysm induction leads to faster AAA growth with aneurysm asymmetry and increased vascular inflammation after 8 weeks, indicating that moderate iliac stenosis may have upstream effects on AAA progression.
Identifiants
pubmed: 31272099
pii: 000501312
doi: 10.1159/000501312
pmc: PMC6819217
mid: NIHMS1041064
doi:
Substances chimiques
Interleukin-6
0
Tgfb1 protein, mouse
0
Transforming Growth Factor beta1
0
Vascular Endothelial Growth Factor A
0
interleukin-6, mouse
0
vascular endothelial growth factor A, mouse
0
Pancreatic Elastase
EC 3.4.21.36
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
217-229Subventions
Organisme : American Heart Association-American Stroke Association
ID : 14SDG18220010
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK101001
Pays : United States
Informations de copyright
© 2019 S. Karger AG, Basel.
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