Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory.
Animals
Astrocytes
/ enzymology
Behavior, Animal
/ physiology
Conditioning, Psychological
/ physiology
Fear
/ physiology
Female
Glutamic Acid
/ metabolism
Hippocampus
/ cytology
Long-Term Synaptic Depression
/ physiology
Male
Memory, Long-Term
/ physiology
Mice
Mice, Inbred C57BL
Mitogen-Activated Protein Kinase 14
/ metabolism
Neurons
/ physiology
Optogenetics
Patch-Clamp Techniques
Receptors, N-Methyl-D-Aspartate
/ metabolism
Synaptic Potentials
/ physiology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
04 07 2019
04 07 2019
Historique:
received:
17
10
2018
accepted:
04
06
2019
entrez:
6
7
2019
pubmed:
6
7
2019
medline:
28
10
2019
Statut:
epublish
Résumé
NMDA receptor-dependent long-term depression (LTD) in the hippocampus is a well-known form of synaptic plasticity that has been linked to different cognitive functions. The core mechanism for this form of plasticity is thought to be entirely neuronal. However, we now demonstrate that astrocytic activity drives LTD at CA3-CA1 synapses. We have found that LTD induction enhances astrocyte-to-neuron communication mediated by glutamate, and that Ca
Identifiants
pubmed: 31273206
doi: 10.1038/s41467-019-10830-9
pii: 10.1038/s41467-019-10830-9
pmc: PMC6609681
doi:
Substances chimiques
Receptors, N-Methyl-D-Aspartate
0
Glutamic Acid
3KX376GY7L
Mitogen-Activated Protein Kinase 14
EC 2.7.11.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2968Subventions
Organisme : Fundación BBVA (BBVA Foundation)
ID : 2015
Pays : International
Organisme : Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness)
ID : SAF2014-58598-JIN
Pays : International
Organisme : Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness)
ID : RYC-2016-20414
Pays : International
Organisme : Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness)
ID : IJCI-2015-25507
Pays : International
Organisme : Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness)
ID : SAF2015-72988-EXP
Pays : International
Organisme : Joint Programming Initiative A healthy diet for a healthy life (JPI A Healthy Diet for a Healthy Life)
ID : PCIN-2016-095
Pays : International
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