[Microsatellite instability and cancer: from genomic instability to personalized medicine].
Instabilité des microsatellites et cancer - De l’instabilité du génome à la médecine personnalisée.
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Historique:
entrez:
6
7
2019
pubmed:
6
7
2019
medline:
16
1
2020
Statut:
ppublish
Résumé
The human tumor phenotype referred to as MSI (Microsatellite Instability) is associated with inactivating alterations in MMR genes (Mismatch Repair). MSI was first observed in inherited malignancies associated with Lynch syndrome and later in sporadic colon, gastric and endometrial cancers. MSI tumors develop through a distinctive molecular pathway characterized by genetic instability in numerous microsatellite DNA repeat sequences throughout the genome. In this article, french researchers and physicians who have been recently awarded by the Fondation de France (Jean and Madeleine Schaeverbeke prize) make a sum of their activity in the MSI cancer field for more than 20 years. Their findings have greatly contributed to increase our knowledge of this original cancer model, laying the foundation for a personalized medicine of MSI tumors.
Identifiants
pubmed: 31274083
doi: 10.1051/medsci/2019093
pii: msc190057
doi:
Substances chimiques
HSP110 Heat-Shock Proteins
0
HSPH1 protein, human
0
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
535-543Informations de copyright
© 2019 médecine/sciences – Inserm.