Reduction of Nanoparticle Load in Cells by Mitosis but Not Exocytosis.

Animals Cells, Cultured Exocytosis Gold / chemistry Lysosomes / chemistry Mice Mitosis Nanoparticles / chemistry Optical Imaging Oxidation-Reduction Particle Size Porosity Silicon Dioxide / chemical synthesis Surface Properties
engineered nanoparticles exocytosis intracellular fate live cell imaging mitosis

Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
23 07 2019
Historique:
pubmed: 6 7 2019
medline: 22 8 2020
entrez: 6 7 2019
Statut: ppublish

Résumé

The long-term fate of biomedically relevant nanoparticles (NPs) at the single cell level after uptake is not fully understood yet. We report that lysosomal exocytosis of NPs is not a mechanism to reduce the particle load. Biopersistent NPs such as nonporous silica and gold remain in cells for a prolonged time. The only reduction of the intracellular NP number is observed

Identifiants

DOI: 10.1021/acsnano.9b01604 PMID: 31276366
pubmed: 31276366
doi: 10.1021/acsnano.9b01604
doi:

Substances chimiques

Gold 7440-57-5
Silicon Dioxide 7631-86-9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7759-7770

Auteurs

Joël Bourquin (J)

Adolphe Merkle Institute , University of Fribourg , Chemin des Verdiers 4 , 1700 Fribourg , Switzerland.
ORCID: 0000-0001-8345-710X

Dedy Septiadi (D)

Adolphe Merkle Institute , University of Fribourg , Chemin des Verdiers 4 , 1700 Fribourg , Switzerland.
ORCID: 0000-0003-2353-7508

Dimitri Vanhecke (D)

Adolphe Merkle Institute , University of Fribourg , Chemin des Verdiers 4 , 1700 Fribourg , Switzerland.

Sandor Balog (S)

Adolphe Merkle Institute , University of Fribourg , Chemin des Verdiers 4 , 1700 Fribourg , Switzerland.
ORCID: 0000-0002-4847-9845

Lukas Steinmetz (L)

Adolphe Merkle Institute , University of Fribourg , Chemin des Verdiers 4 , 1700 Fribourg , Switzerland.
ORCID: 0000-0003-4255-2738

Miguel Spuch-Calvar (M)

Adolphe Merkle Institute , University of Fribourg , Chemin des Verdiers 4 , 1700 Fribourg , Switzerland.
ORCID: 0000-0002-6679-2624

Patricia Taladriz-Blanco (P)

Adolphe Merkle Institute , University of Fribourg , Chemin des Verdiers 4 , 1700 Fribourg , Switzerland.
ORCID: 0000-0002-2469-9704

Alke Petri-Fink (A)

Adolphe Merkle Institute , University of Fribourg , Chemin des Verdiers 4 , 1700 Fribourg , Switzerland.
Department of Chemistry , University of Fribourg , Chemin du Musée 9 , 1700 Fribourg , Switzerland.
ORCID: 0000-0003-3952-7849

Barbara Rothen-Rutishauser (B)

Adolphe Merkle Institute , University of Fribourg , Chemin des Verdiers 4 , 1700 Fribourg , Switzerland.
ORCID: 0000-0002-7805-9366

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Cellules › Cellules cultivées › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Exocytose › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Or › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Mitose › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Phénomènes chimiques › Taille de particule › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Porosité › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du silicium › Silice › Reduction of Nanoparticle Load in Cells by...
questionsmedicales.fr › Phénomènes chimiques › Propriétés de surface › Reduction of Nanoparticle Load in Cells by...