Targeted gold nanoparticles enable molecular CT imaging of head and neck cancer: An in vivo study.

Animals Contrast Media / chemistry Gold / chemistry Head and Neck Neoplasms / diagnostic imaging Metal Nanoparticles / chemistry Mice Neoplasms, Experimental / diagnostic imaging Tomography, X-Ray Computed
Cancer Folic acid Gold nanoparticles Molecular CT imaging

Journal

The international journal of biochemistry & cell biology
ISSN: 1878-5875
Titre abrégé: Int J Biochem Cell Biol
Pays: Netherlands
ID NLM: 9508482

Informations de publication

Date de publication:
09 2019
Historique:
received: 29 01 2019
revised: 07 06 2019
accepted: 10 06 2019
pubmed: 6 7 2019
medline: 20 3 2020
entrez: 6 7 2019
Statut: ppublish

Résumé

The development of various cost-effective multifunctional contrast agent for specific targeting molecular imaging of tumors presents a great challenge. We report here the in vivo targeting imaging of folic acid (FA) gold nanoparticles (AuNPs) through cysteamine (Cys) linking for targeted of human nasopharyngeal head and neck cancer by computed tomography (CT). The toxicity of nanoparticles in kidney, heart, spleen, brain and liver was evaluated by H&E (hematoxylin and eosin) assay. We showed that the formed FA-Cys-AuNPs with an Au core size of ˜13 nm are non-cytotoxic in the particle concentration of 3 × 10

Identifiants

DOI: 10.1016/j.biocel.2019.06.002 PMID: 31276787
pubmed: 31276787
pii: S1357-2725(19)30125-6
doi: 10.1016/j.biocel.2019.06.002
pii:
doi:

Substances chimiques

Contrast Media 0
Gold 7440-57-5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105554

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Sara Khademi (S)

Department of Radiology Technology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.

Saeed Sarkar (S)

Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran.

Ali Shakeri-Zadeh (A)

Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Neda Attaran (N)

Department of Medical Nanotechnology, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Sharmin Kharrazi (S)

Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Mohammad Reza Ay (MR)

Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran.

Hosein Azimian (H)

Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Hossein Ghadiri (H)

Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: h-ghadiri@sina.tums.ac.ir.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Targeted gold nanoparticles enable molecular...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits de contraste › Targeted gold nanoparticles enable molecular...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Or › Targeted gold nanoparticles enable molecular...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Targeted gold nanoparticles enable molecular...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanoparticules métalliques › Targeted gold nanoparticles enable molecular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Targeted gold nanoparticles enable molecular...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Tumeurs expérimentales › Targeted gold nanoparticles enable molecular...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Targeted gold nanoparticles enable molecular...