Eicosanoid Profile of Influenza A Virus Infected Pigs.
Influenza A virus
eicosanoids
infection
lipid mediator
pig
Journal
Metabolites
ISSN: 2218-1989
Titre abrégé: Metabolites
Pays: Switzerland
ID NLM: 101578790
Informations de publication
Date de publication:
03 Jul 2019
03 Jul 2019
Historique:
received:
28
05
2019
revised:
28
06
2019
accepted:
28
06
2019
entrez:
7
7
2019
pubmed:
7
7
2019
medline:
7
7
2019
Statut:
epublish
Résumé
Respiratory tract infections caused by the Influenza A virus (IAV) are a worldwide problem for human and animal health. Within this study, we analyzed the impact of IAV infection on the immune-related lipidome (eicosanoids) of the pig as new infection model. For this purpose, we performed HPLC-MS/MS using dynamic multiple reaction monitoring and analyzed lung, spleen, blood plasma and bronchoalveolar lavages. IAV infection leads to collective changes in the levels of the analyzed hydroxyeicosatrienoic acids (HETEs), hydroxydocosahexaenoic acids (HDHAs) and epoxyeicosatrienoic acids (EETs), and moreover, unique eicosanoid changes in several sample types, even under mild infection conditions. In accordance with different mouse infection studies, we observed infection-related patterns for 12-HETE, 15-HETE and 17-HDHA, which seem to be common for IAV infection. Using a long-term approach of 21 days we established an experimental setup that can be used also for bacterial-viral coinfection experiments.
Identifiants
pubmed: 31277231
pii: metabo9070130
doi: 10.3390/metabo9070130
pmc: PMC6680658
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : State of Mecklenburg Western Pomerania and European Social Fund (ESF)
ID : ESF_14-BM-A55-0005_16
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK1870
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