MRI identifies biochemical alterations of intervertebral discs in patients with low back pain and radiculopathy.
Adult
Aged
Aged, 80 and over
Biomarkers
/ analysis
Female
Glycosaminoglycans
/ metabolism
Humans
Intervertebral Disc
/ diagnostic imaging
Intervertebral Disc Degeneration
/ complications
Low Back Pain
/ etiology
Lumbar Vertebrae
/ metabolism
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Prospective Studies
Radiculopathy
/ etiology
Young Adult
Journal
European radiology
ISSN: 1432-1084
Titre abrégé: Eur Radiol
Pays: Germany
ID NLM: 9114774
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
02
05
2019
accepted:
05
06
2019
revised:
16
05
2019
pubmed:
7
7
2019
medline:
6
2
2020
entrez:
7
7
2019
Statut:
ppublish
Résumé
• Molecular intervertebral disc damage was associated with LBP and radiculopathy.• Patients with radiculopathy and LBP demonstrated a depletion of gagCEST values compared with healthy controls.• GagCEST imaging may be a non-invasive tool for investigation of degeneration processes of lumbar intervertebral discs (IVDs). GagCEST imaging may be an imaging biomarker for biochemical IVD alterations.
Identifiants
pubmed: 31278582
doi: 10.1007/s00330-019-06305-6
pii: 10.1007/s00330-019-06305-6
doi:
Substances chimiques
Biomarkers
0
Glycosaminoglycans
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
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