A nonlinear relationship between visceral adipose tissue and frailty in adult lung transplant candidates.
Adult
Aged
Body Mass Index
Cross-Sectional Studies
Female
Follow-Up Studies
Frailty
/ epidemiology
Humans
Incidence
Intra-Abdominal Fat
/ physiopathology
Lung Transplantation
Male
Middle Aged
Obesity, Abdominal
/ physiopathology
Prognosis
Prospective Studies
Risk Factors
Subcutaneous Fat
/ physiopathology
Tomography, X-Ray Computed
United States
/ epidemiology
clinical research/practice
lung transplantation/pulmonology
obesity
quality of life (QOL)
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
20
02
2019
revised:
12
06
2019
accepted:
22
06
2019
pubmed:
7
7
2019
medline:
12
9
2020
entrez:
7
7
2019
Statut:
ppublish
Résumé
Frailty is a state of decreased physiologic reserve associated with poor outcomes before and after lung transplantation. Obesity, particularly central obesity characterized by excess proinflammatory visceral adipose tissue (VAT), is associated with incident frailty in middle-aged and older adults. The association between VAT and frailty in advanced lung disease, however, is unknown. In two, nonoverlapping multicenter cohorts of adults listed for lung transplantation, we measured VAT area on bioelectrical impedance assay (BIA) in one cohort and cross-sectional VAT and subcutaneous adipose tissue (SAT) areas on abdominal computed tomography (CT) in the other. We identified a nonlinear relationship between greater VAT by BIA and frailty. In fully adjusted piecewise regression models, every 20 cm
Identifiants
pubmed: 31278829
doi: 10.1111/ajt.15525
pmc: PMC7863776
mid: NIHMS1658899
pii: S1600-6135(22)09307-8
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3155-3161Subventions
Organisme : CSRD VA
ID : IK2 CX001034
Pays : United States
Organisme : Stony Wold-Herbert Fund
Pays : International
Organisme : NHLBI NIH HHS
ID : K24 HL115354
Pays : United States
Organisme : NHLBI NIH HHS
ID : L30 HL143645
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134851
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087115
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL105323
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL 114626
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL114626
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL131937
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL 134851
Pays : United States
Informations de copyright
© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.
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