Vendor-specific microbiome controls both acute and chronic murine lung allograft rejection by altering CD4
Allografts
Animals
CD4-Positive T-Lymphocytes
/ immunology
Commerce
/ standards
Forkhead Transcription Factors
/ physiology
Graft Rejection
/ etiology
Graft Survival
/ immunology
Lung Diseases
/ immunology
Lung Transplantation
/ adverse effects
Male
Mice
Mice, Inbred C57BL
Microbiota
T-Lymphocytes, Regulatory
/ immunology
Transplant Recipients
animal models: murine
basic (laboratory) research/science
bronchiolitis obliterans (BOS)
immunosuppression/immune modulation
lung disease: immune/inflammatory
lung transplantation/pulmonology
rejection: acute
rejection: chronic
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
14
05
2019
revised:
09
06
2019
accepted:
24
06
2019
pubmed:
7
7
2019
medline:
5
9
2020
entrez:
7
7
2019
Statut:
ppublish
Résumé
Despite standardized postoperative care, some lung transplant patients suffer multiple episodes of acute and chronic rejection while others avoid graft problems for reasons that are poorly understood. Using an established model of C57BL/10 to C57BL/6 minor antigen mismatched single lung transplantation, we now demonstrate that the recipient microbiota contributes to variability in the alloimmune response. Specifically, mice from the Envigo facility in Frederick, Maryland contain nearly double the number of CD4
Identifiants
pubmed: 31278849
doi: 10.1111/ajt.15523
pmc: PMC7919421
mid: NIHMS1660976
pii: S1600-6135(22)09256-5
doi:
Substances chimiques
Forkhead Transcription Factors
0
Foxp3 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2705-2718Subventions
Organisme : NIAID NIH HHS
ID : R01 AI145108
Pays : United States
Organisme : NCI NIH HHS
ID : R41 CA224520
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA044579
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI116501
Pays : United States
Organisme : BLRD VA
ID : I01 BX002299
Pays : United States
Organisme : BLRD VA
ID : I01 BX004588
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL113931
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.
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