Antibiotic residues in livestock manure: Does the EU risk assessment sufficiently protect against microbial toxicity and selection of resistant bacteria in the environment?
Animals
Anti-Bacterial Agents
/ toxicity
Bacillus
/ drug effects
Cyanobacteria
/ drug effects
Drug Residues
/ toxicity
Drug Resistance, Bacterial
/ drug effects
European Union
Livestock
Manure
/ microbiology
Microbial Sensitivity Tests
Pseudomonas
/ drug effects
Risk Assessment
Soil Microbiology
Soil Pollutants
/ toxicity
Veterinary Drugs
/ toxicity
Antimicrobial resistance
Soil
Surface water
VetCalc
Veterinary antibiotic
Journal
Journal of hazardous materials
ISSN: 1873-3336
Titre abrégé: J Hazard Mater
Pays: Netherlands
ID NLM: 9422688
Informations de publication
Date de publication:
05 11 2019
05 11 2019
Historique:
received:
22
03
2019
revised:
28
05
2019
accepted:
20
06
2019
pubmed:
7
7
2019
medline:
22
9
2020
entrez:
7
7
2019
Statut:
ppublish
Résumé
Antibiotic residues that reach the environment via land application of livestock manure could impact structure and function of microbial communities and promote the spread of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs). To assess whether there is a risk, we have reviewed extensive data on five veterinary antibiotics (VAs) that are commonly used in livestock farming (amoxicillin, enrofloxacin, sulfadiazine, tetracycline, trimethoprim). Predicted environmental concentrations (PECs) after the medication of pigs were derived using (i) a total residue approach and (ii) the VetCalc model to account for additional fate parameters and regional scenarios specific to Germany. Predicted no effect concentrations (PNECs) for microbial toxicity and ARB selection were derived from available concentration-response data. Except for enrofloxacin, the total residue PECs exceeded 100 μg kg
Identifiants
pubmed: 31279308
pii: S0304-3894(19)30760-5
doi: 10.1016/j.jhazmat.2019.120807
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Manure
0
Soil Pollutants
0
Veterinary Drugs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
120807Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.